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Biology and Biochemistry

D-Index
84
Citations
38738
World Ranking
3241
National Ranking
246

Overview

Holger Gerhardt is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research focuses primarily on the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these domains, their work emphasizes Molecular Biology, Cell Biology, Immunology, Cardiology and Cardiovascular Medicine, and Biomedical Engineering.

The scientist has contributed to several significant topics, including:

  • Angiogenesis and VEGF in Cancer
  • Hippo pathway signaling and YAP/TAZ
  • Zebrafish Biomedical Research Applications
  • Single-cell and spatial transcriptomics
  • Congenital heart defects research
  • Immune cells in cancer
  • Cellular Mechanics and Interactions

Gerhardt's frequent co-authors include Wolfgang Giese, Miguel O. Bernabéu, Elisabeth Baumann, Baptiste Coxam, and Eireen Bartels-Klein.

Their research has been published widely, with many contributions appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), AEA Randomized Controlled Trials, Development, Nature Cardiovascular Research, and Cells.

Among notable recent papers are:

  • "Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance" (2020) in Progress in Neurobiology
  • "The Genetic Basis of Moyamoya Disease" (2021) in Translational Stroke Research
  • "Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways" (2021) in Frontiers in Physiology
  • "A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth" (2022) in Nature Metabolism
  • "Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis" (2022) in Nature Cardiovascular Research

Gerhardt's work explores mechanisms of blood vessel formation, signaling pathways involved in cellular growth and polarity, and the molecular underpinnings of cardiovascular diseases.

Best Publications

  • VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

    Holger Gerhardt;Matthew Golding;Marcus Fruttiger;Christiana Ruhrberg

  • Basic and Therapeutic Aspects of Angiogenesis

    Michael Potente;Holger Gerhardt;Holger Gerhardt;Peter Carmeliet

  • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

    Mats Hellström;Li Kun Phng;Jennifer J. Hofmann;Elisabet Wallgard

  • Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

    Katrien De Bock;Maria Georgiadou;Sandra Schoors;Anna Kuchnio

  • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.

    Mats Hellström;Holger Gerhardt;Holger Gerhardt;Mattias Kalén;Xuri Li

  • Endothelial-pericyte interactions in angiogenesis

    Holger Gerhardt;Christer Betsholtz

  • Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

    Christiana Ruhrberg;Holger Gerhardt;Matthew Golding;Rose Watson

  • Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

    Lars Jakobsson;Claudio A. Franco;Katie Bentley;Russell T. Collins

  • Angiogenesis: A Team Effort Coordinated by Notch

    L.-K. Phng;Holger Gerhardt

  • Wnt/β-catenin signaling controls development of the blood–brain barrier

    Stefan Liebner;Monica Corada;Thorsten Bangsow;Jane Babbage

  • Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.

    Per Lindblom;Holger Gerhardt;Stefan Liebner;Alexandra Abramsson

  • VEGF and Notch in Tip and Stalk Cell Selection

    Raquel Blanco;Holger Gerhardt

  • Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

    Mariona Graupera;Julie Guillermet-Guibert;Lazaros C. Foukas;Li-Kun Phng

  • Fatty acid carbon is essential for dNTP synthesis in endothelial cells

    Sandra Schoors;Ulrike Bruning;Rindert Missiaen;Karla C S Queiroz

  • A new method for large scale isolation of kidney glomeruli from mice.

    Minoru Takemoto;Noomi Asker;Holger Gerhardt;Andrea Lundkvist

  • Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.

    Sandra Schoors;Katrien De Bock;Anna Rita Cantelmo;Maria Georgiadou

  • FOXO1 couples metabolic activity and growth state in the vascular endothelium.

    Kerstin Wilhelm;Katharina Happel;Guy Eelen;Sandra Schoors

  • Coordinating cell behaviour during blood vessel formation

    Ilse Geudens;Holger Gerhardt;Holger Gerhardt

  • Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.

    Maria Enge;Mattias Bjarnegård;Holger Gerhardt;Erika Gustafsson

  • Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

    Christopher A. Jones;Nyall R. London;Haoyu Chen;Kye Won Park;Kye Won Park

Frequent Co-Authors

Christer Betsholtz
Christer Betsholtz Uppsala University
Hartwig Wolburg
Hartwig Wolburg University of Tübingen
Elisabetta Dejana
Elisabetta Dejana Uppsala University
Richard A. Lang
Richard A. Lang Cincinnati Children's Hospital Medical Center
Peter V. Coveney
Peter V. Coveney University College London
Ralf H. Adams
Ralf H. Adams Max Planck Society
Robert Kiss
Robert Kiss Université Libre de Bruxelles

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