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Massimiliano Mazzone

Massimiliano Mazzone

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
26360
World Ranking
3848
National Ranking
63

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Massimiliano Mazzone is affiliated with KU Leuven in Belgium and has notable contributions across several interconnected fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Their research output covers a broad range of scientific topics, with particular attention to molecular biology, cancer research, immunology, oncology, and pulmonary and respiratory medicine.

The primary topics addressed by their work include:

  • Cancer, Hypoxia, and Metabolism
  • Immune cells in cancer
  • MicroRNA in disease regulation
  • Angiogenesis and VEGF in Cancer
  • Immune Cell Function and Interaction
  • Phagocytosis and Immune Regulation
  • Epigenetics and DNA Methylation

Mazzone has contributed frequently to various publication venues with multiple works appearing particularly in bioRxiv (Cold Spring Harbor Laboratory), Nature Metabolism, Cancer Immunology Research, Science Advances, and Zenodo (CERN European Organization for Nuclear Research).

Collaborative efforts have involved several recurring co-authors, including:

  • Peter Carmeliet
  • Diether Lambrechts
  • Mario Di Matteo
  • Carla Riera-Domingo
  • Guy Eelen

Among recent high-impact papers authored or co-authored by Mazzone are:

  • "An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates" (2020, Cancer Cell)
  • "Mitochondria metabolism sets the species-specific tempo of neuronal development" (2023, Science)
  • "Macrophage-derived glutamine boosts satellite cells and muscle regeneration" (2020, Nature)
  • "Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis" (2020, Cell Metabolism)
  • "PHGDH heterogeneity potentiates cancer cell dissemination and metastasis" (2022, Nature)

The scientist's work integrates complex biological processes such as cellular metabolism, immune system regulation, and cancer microenvironment dynamics. Their role in advancing the understanding of angiogenesis, immune cell function, and cancer progression is reflected in their broad scientific influence.

Massimiliano Mazzone has been recognized as a member of the European Molecular Biology Organization (EMBO), highlighting their engagement with a leading community in molecular biology research.

Best Publications

  • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.

    Selma Pennacchietti;Paolo Michieli;Maria Galluzzo;Massimiliano Mazzone

  • Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

    Christian Fischer;Bart Jonckx;Massimiliano Mazzone;Serena Zacchigna

  • Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

    Massimiliano Mazzone;Massimiliano Mazzone;Daniela Dettori;Daniela Dettori;Daniela Dettori;Rodrigo Leite de Oliveira;Rodrigo Leite de Oliveira;Sonja Loges;Sonja Loges

  • α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

    Pu-Ste Liu;Haiping Wang;Xiaoyun Li;Tung Chao

  • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

    Charlotte Rolny;Massimiliano Mazzone;Sònia Tugues;Damya Laoui

  • FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?

    Christian Fischer;Massimiliano Mazzone;Massimiliano Mazzone;Bart Jonckx;Bart Jonckx;Peter Carmeliet;Peter Carmeliet

  • Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

    Andrea Casazza;Damya Laoui;Mathias Wenes;Sabrina Rizzolio

  • Tumour hypoxia causes DNA hypermethylation by reducing TET activity

    Bernard Thienpont;Jessica Steinbacher;Hui Zhao;Flora D’Anna

  • Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

    Julián Aragonés;Martin Schneider;Martin Schneider;Martin Schneider;Katie Van Geyte;Katie Van Geyte;Peter Fraisl;Peter Fraisl

  • Role and Therapeutic Potential of VEGF in the Nervous System

    Carmen Ruiz de Almodovar;Diether Lambrechts;Massimiliano Mazzone;Peter Carmeliet

  • Regulation of Angiogenesis by Oxygen and Metabolism

    Peter Fraisl;Massimiliano Mazzone;Thomas Schmidt;Peter Carmeliet

  • Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited.

    Sonja Loges;Massimiliano Mazzone;Philipp Hohensinner;Peter Carmeliet

  • MET is required for the recruitment of anti-tumoural neutrophils

    Veronica Finisguerra;Giusy Di Conza;Mario Di Matteo;Jens Serneels

  • Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population

    Damya Laoui;Eva Van Overmeire;Giusy Di Conza;Chiara Aldeni

  • Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

    Mathias Wenes;Min Shang;Mario Di Matteo;Jermaine Goveia

  • The impact of hypoxia on tumor-associated macrophages.

    Anne-Theres Henze;Massimiliano Mazzone

  • Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting.

    Fanny Langlet;Barry E. Levin;Barry E. Levin;Serge Luquet;Massimiliano Mazzone

  • An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

    Jermaine Goveia;Katerina Rohlenova;Federico Taverna;Lucas Treps

  • Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.

    Paolo Michieli;Massimiliano Mazzone;Cristina Basilico;Silvia Cavassa

  • Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

    Katrien De Bock;Massimiliano Mazzone;Peter Carmeliet

Frequent Co-Authors

Paolo M. Comoglio
Paolo M. Comoglio FIRC Institute of Molecular Oncology
Luca Tamagnone
Luca Tamagnone Catholic University of the Sacred Heart
Jo A. Van Ginderachter
Jo A. Van Ginderachter Vrije Universiteit Brussel
Lena Claesson-Welsh
Lena Claesson-Welsh Uppsala University
Karen Blyth
Karen Blyth University of Glasgow

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