D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 60 Citations 15,457 105 World Ranking 5319 National Ranking 100

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Cancer
  • Enzyme

Her primary scientific interests are in Cancer research, Receptor tyrosine kinase, Tyrosine kinase, Molecular biology and Hepatocyte growth factor. The Cancer research study combines topics in areas such as Cancer, Targeted therapy, Metastasis and Tumor progression. The study incorporates disciplines such as Cell surface receptor, Proto-oncogene tyrosine-protein kinase Src and Platelet-derived growth factor receptor in addition to Receptor tyrosine kinase.

Silvia Giordano works mostly in the field of Tyrosine kinase, limiting it down to concerns involving Drug resistance and, occasionally, Lung cancer, KRAS, Cetuximab, Panitumumab and Growth factor receptor. Her Hepatocyte growth factor research integrates issues from Cell culture, Epithelial polarity and Northern blot. Her Cell biology study which covers Receptor that intersects with Downregulation and upregulation.

Her most cited work include:

  • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. (1064 citations)
  • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family (874 citations)
  • Drug development of MET inhibitors : targeting oncogene addiction and expedience (709 citations)

What are the main themes of her work throughout her whole career to date?

Silvia Giordano mainly investigates Cancer research, Receptor tyrosine kinase, Tyrosine kinase, Cell biology and Cancer. Her studies in Cancer research integrate themes in fields like Hepatocyte growth factor, Cancer cell, Carcinogenesis, Oncogene and Targeted therapy. Her Receptor tyrosine kinase research is multidisciplinary, incorporating perspectives in Protein tyrosine phosphatase, Proto-oncogene tyrosine-protein kinase Src, ROR1, Platelet-derived growth factor receptor and Molecular biology.

In Tyrosine kinase, Silvia Giordano works on issues like Phosphorylation, which are connected to Tyrosine. Her Cell biology study integrates concerns from other disciplines, such as Semaphorin, Receptor and C-Met. Her work deals with themes such as Pathology, Oncology and Pharmacology, which intersect with Cancer.

She most often published in these fields:

  • Cancer research (47.09%)
  • Receptor tyrosine kinase (29.10%)
  • Tyrosine kinase (28.04%)

What were the highlights of her more recent work (between 2016-2021)?

  • Cancer research (47.09%)
  • Cancer (22.22%)
  • Internal medicine (15.34%)

In recent papers she was focusing on the following fields of study:

Her primary areas of investigation include Cancer research, Cancer, Internal medicine, Oncology and Cancer cell. Her Cancer research study combines topics from a wide range of disciplines, such as Tyrosine kinase, Targeted therapy, Downregulation and upregulation and Transplantation. Her research investigates the connection with Tyrosine kinase and areas like Epidermal growth factor receptor which intersect with concerns in AXL receptor tyrosine kinase, Hippo signaling pathway, Cell biology and Epithelial–mesenchymal transition.

Her biological study spans a wide range of topics, including EGFR inhibitors and Signal transduction, Receptor tyrosine kinase. Her Cancer study incorporates themes from Cell culture and Clinical trial, Pathology. Her Cancer cell research also works with subjects such as

  • Oncogene together with Cell signaling, Autocrine signalling, Galectin-1 and Kinase activity,
  • Kinase together with Lung cancer, Tumor microenvironment and Hepatocyte growth factor.

Between 2016 and 2021, her most popular works were:

  • Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies. (71 citations)
  • Targeted therapies for gastric cancer: failures and hopes from clinical trials (55 citations)
  • Biomarkers of primary resistance to trastuzumab in HER2-positive metastatic gastric cancer patients: the AMNESIA case-control study (39 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.

Selma Pennacchietti;Paolo Michieli;Maria Galluzzo;Massimiliano Mazzone.
Cancer Cell (2003)

1405 Citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

Carola Ponzetto;Alberto Bardelli;Alberto Bardelli;Zhu Zhen;Flavio Maina.
Cell (1994)

1140 Citations

Drug development of MET inhibitors : targeting oncogene addiction and expedience

Paolo M. Comoglio;Silvia Giordano;Livio Trusolino.
Nature Reviews Drug Discovery (2008)

879 Citations

Overexpression and amplification of the Met/HGF receptor gene during the progression of colorectal cancer

M F Di Renzo;M Olivero;A Giacomini;H Porte.
Clinical Cancer Research (1995)

663 Citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

M. F. Di Renzo;R. P. Narsimhan;M. Olivero;S. Bretti.
Oncogene (1991)

623 Citations

Tyrosine kinase receptor indistinguishable from the c-met protein.

S. Giordano;C. Ponzetto;M. F. Di Renzo;C. S. Cooper.
Nature (1989)

545 Citations

Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

Alberto Bardelli;Simona Corso;Andrea Bertotti;Sebastijan Hobor.
Cancer Discovery (2013)

539 Citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

Annalisa Petrelli;Giorgio F. Gilestro;Stefania Lanzardo;Paolo M. Comoglio.
Nature (2002)

510 Citations

The Semaphorin 4D receptor controls invasive growth by coupling with Met

Silvia Giordano;Simona Corso;Paolo Conrotto;Stefania Artigiani.
Nature Cell Biology (2002)

501 Citations

From single- to multi- target drugs in cancer therapy: when aspecificity becomes an advantage

Annalisa Petrelli;Silvia Giordano.
Current Medicinal Chemistry (2008)

466 Citations

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