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Stefan Offermanns

Stefan Offermanns

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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
121
Citations
53660
World Ranking
607
National Ranking
41

Medicine

D-Index
121
Citations
53643
World Ranking
3611
National Ranking
192

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2006 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Physiology and Pharmacology/Toxicology

Overview

Stefan Offermanns is affiliated with the Max Planck Society in Germany, where the primary focus is on research within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields, including Molecular Biology, Immunology, Physiology, Cell Biology, and Cellular and Molecular Neuroscience.

The research topics explored by Offermanns include:

  • Hippo pathway signaling and YAP/TAZ
  • Receptor Mechanisms and Signaling
  • Axon Guidance and Neuronal Signaling
  • Eicosanoids and Hypertension Pharmacology
  • Biochemical Analysis and Sensing Techniques
  • Neuropeptides and Animal Physiology
  • Ion Channels and Receptors

Recent notable papers authored or co-authored by Offermanns include:

  • "Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling," 2020, Nature Communications
  • "The Concise Guide to PHARMACOLOGY 2023/24: Ion channels," 2023, British Journal of Pharmacology
  • "Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?," 2022, Frontiers in Pharmacology
  • "Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice," 2020, Nature Communications
  • "Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis," 2022, Blood

Frequent publication venues include:

  • Nature Communications (14 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (9 publications)
  • The FASEB Journal (5 publications)
  • Circulation (4 publications)
  • British Journal of Pharmacology (3 publications)

Offermanns has collaborated regularly with several researchers, with frequent co-authors being:

  • Nina Wettschureck (21 collaborations)
  • Stefan Günther (15 collaborations)
  • Shengpeng Wang (12 collaborations)
  • Rémy Bonnavion (11 collaborations)
  • Jingchen Shao (9 collaborations)

In 2006, Offermanns was recognized by the German National Academy of Sciences Leopoldina in the category of Physiology and Pharmacology/Toxicology.

Best Publications

  • Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

    Nagendra Singh;Ashish Gurav;Sathish Sivaprakasam;Evan Brady

  • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

    Pamela V. Chang;Liming Hao;Stefan Offermanns;Ruslan Medzhitov

  • Mammalian G proteins and their cell type specific functions

    Nina Wettschureck;Stefan Offermanns

  • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

    Laurence Macia;Jian Tan;Angelica T. Vieira;Katie Leach

  • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.

    Sorin Tunaru;Jukka Kero;Annette Schaub;Christian Wufka;Christian Wufka

  • Activation of Platelet Function Through G Protein–Coupled Receptors

    Stefan Offermanns

  • Defective platelet activation in G alpha q deficient mice

    Stefan Offermanns;Christopher F. Toombs;Yi-Hui Hu;Melvin I. Simon

  • Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C

    Stefan Offermanns;Melvin I. Simon

  • G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension.

    Angela Wirth;Zoltán Benyó;Zoltán Benyó;Martina Lukasova;Barbara Leutgeb;Barbara Leutgeb

  • Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

    Dagmar Schumacher;Boris Strilic;Kishor Kumar Sivaraj;Nina Wettschureck;Nina Wettschureck

  • (d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G

    Andrew K.P. Taggart;Jukka Kero;Xiaodong Gan;Tian-Quan Cai

  • G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

    Stefan Offermanns;Karl-Ludwig Laugwitz;Karsten Spicher;Gunter Schultz

  • Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

    ShengPeng Wang;Ramesh Chennupati;Harmandeep Kaur;Andras Iring

  • Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.

    Jakub M. Swiercz;Rohini Kuner;Jürgen Behrens;Stefan Offermanns

  • The Concise Guide to PHARMACOLOGY 2017/18: Overview

    Stephen P. H. Alexander;Eamonn Kelly;Neil V. Marrion;John A. Peters

  • GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

    Mark K. Nøhr;Maria H. Pedersen;Andreas Gille;Kristoffer L. Egerod

  • Regeneration of fat cells from myofibroblasts during wound healing

    Maksim V. Plikus;Maksim V. Plikus;Christian F. Guerrero-Juarez;Mayumi Ito;Yun Rose Li

  • Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

    Birgit Klages;Ursula Brandt;Melvin I. Simon;Günter Schultz

  • Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency

    Stefan Offermanns;Valeria Mancino;Jean-Paul Revel;Melvin I. Simon

  • Rho/Rho-kinase mediated signaling in physiology and pathophysiology.

    Nina Wettschureck;Stefan Offermanns

Frequent Co-Authors

Günter Schultz
Günter Schultz Freie Universität Berlin
Melvin I. Simon
Melvin I. Simon California Institute of Technology
Rohini Kuner
Rohini Kuner Heidelberg University
Ernesto L. Schiffrin
Ernesto L. Schiffrin McGill University
Didier Y. R. Stainier
Didier Y. R. Stainier Max Planck Society
Thomas Gudermann
Thomas Gudermann Ludwig-Maximilians-Universität München
Melvin I. Simon
Melvin I. Simon University of California, San Diego
Masanobu Kano
Masanobu Kano University of Tokyo
Roland Seifert
Roland Seifert Hannover Medical School
Walter Rosenthal
Walter Rosenthal Freie Universität Berlin

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