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Amedeo Columbano

Amedeo Columbano

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
9824
World Ranking
14012
National Ranking
417

Overview

Amedeo Columbano is affiliated with the University of Cagliari in Italy and has a research profile focused on biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields including molecular biology, cancer research, endocrinology, diabetes and metabolism, hepatology, and epidemiology.

The scientist's recent publications highlight a strong interest in liver diseases, cancer metabolism, and thyroid hormone receptor research. Notable papers include:

  • TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD (2021), published in International Journal of Molecular Sciences
  • Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming (2020), Journal of Hepatology
  • Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? (2020), Frontiers in Oncology
  • Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis (2023), Frontiers in Oncology
  • Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration (2020), Cell Proliferation

Frequent co-authors contributing to the body of work alongside Columbano include Marta Anna Kowalik, Andrea Perra, Marina Serra, Silvia Giordano, and Andrea Caddeo. These collaborations represent sustained research partnerships across multiple projects.

Research outputs have been published repeatedly in several prominent venues, reflecting consistent focus areas. The main publication venues are:

  • Frontiers in Oncology
  • Journal of Hepatology
  • Cancers
  • Cell Proliferation
  • Cellular and Molecular Gastroenterology and Hepatology

Key research topics covered in Columbano's work include:

  • Liver Disease Diagnosis and Treatment
  • Cancer, Hypoxia, and Metabolism
  • Liver Physiology and Pathology
  • Genomics, Phytochemicals, and Oxidative Stress
  • Epigenetics and DNA Methylation
  • Glutathione Transferases and Polymorphisms
  • Diet, Metabolism, and Disease

Best Publications

  • The Dual Roles of NRF2 in Cancer

    Silvia Menegon;Amedeo Columbano;Silvia Giordano

  • MicroRNAs: New tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?†

    Silvia Giordano;Amedeo Columbano

  • CELL-DEATH - CURRENT DIFFICULTIES IN DISCRIMINATING APOPTOSIS FROM NECROSIS IN THE CONTEXT OF PATHOLOGICAL PROCESSES IN-VIVO

    Amedeo Columbano

  • Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures.

    A. Columbano;S. Rajalakshmi;D. S. R. Sarma

  • Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide.

    G. M. Ledda-Columbano;P. Coni;M. Curto;L. Giacomini

  • Occurrence of cell death (apoptosis) during the involution of liver hyperplasia.

    A Columbano;G M Ledda-Columbano;P P Coni;G Faa

  • YAP activation is an early event and a potential therapeutic target in liver cancer development

    Andrea Perra;Marta Anna Kowalik;Elena Ghiso;Giovanna Maria Ledda-Columbano

  • Liver regeneration versus direct hyperplasia.

    Amedeo Columbano;Hisashi Shinozuka

  • Met as a therapeutic target in HCC: Facts and hopes

    Silvia Giordano;Amedeo Columbano

  • MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon Cancer

    Cristina Migliore;Valentina Martin;Vera P. Leoni;Angelo Restivo

  • Progenitor-derived hepatocellular carcinoma model in the rat†

    Jesper B. Andersen;Roberto Loi;Andrea Perra;Valentina M. Factor

  • MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)

    Annalisa Petrelli;Andrea Perra;Davide Cora;Pia Sulas

  • Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3)

    Monica Pibiri;Giovanna M. Ledda-Columbano;Costanza Cossu;Gabriella Simbula

  • Estimation of a significance threshold for epigenome-wide association studies.

    Ayden Saffari;Ayden Saffari;Matt J. Silver;Patrizia Zavattari;Loredana Moi

  • Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma.

    Marta Anna Kowalik;Amedeo Columbano;Andrea Perra

  • Liver cell proliferation induced by a single dose of lead nitrate.

    A Columbano;G M Ledda;P Sirigu;T Perra

  • Rapid induction of apoptosis in rat liver by cycloheximide.

    G M Ledda-Columbano;P Coni;G Faa;G Manenti

  • A common set of immediate-early response genes in liver regeneration and hyperplasia.

    Joseph Locker;Jianmin Tian;Robert Carver;Danilo Concas;Danilo Concas

  • In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway.

    G M Ledda-Columbano;M Curto;R Piga;A I Zedda

  • Gadd45β is induced through a CAR‐dependent, TNF‐independent pathway in murine liver hyperplasia

    Amedeo Columbano;Giovanna M. Ledda-Columbano;Monica Pibiri;Costanza Cossu

Frequent Co-Authors

Silvia Giordano
Silvia Giordano University of Turin
Paolo Pani
Paolo Pani Sapienza University of Rome
Joseph Locker
Joseph Locker University of Pittsburgh
Alessandro Weisz
Alessandro Weisz University of Salerno
Satdarshan P. Monga
Satdarshan P. Monga University of Pittsburgh
Luigi Terracciano
Luigi Terracciano University Hospital of Basel
Andrea Rasola
Andrea Rasola University of Padua
Hisanori Suzuki
Hisanori Suzuki University of Verona
Paola Chiarugi
Paola Chiarugi University of Florence
Masanao Miwa
Masanao Miwa Nagahama Institute of Bio-Science and Technology

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