World's Best Scientists 2026 revealed!
George K. Michalopoulos

George K. Michalopoulos

D-Index & Metrics

Biology and Biochemistry

D-Index
109
Citations
43912
World Ranking
1005
National Ranking
611

Medicine

D-Index
109
Citations
43797
World Ranking
5782
National Ranking
3105

Overview

George K. Michalopoulos is affiliated with the University of Pittsburgh in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a focus on hepatology, molecular biology, surgery, epidemiology, and cell biology.

Their recent notable publications include the following:

  • Liver regeneration: biological and pathological mechanisms and implications, 2020, Nature Reviews Gastroenterology & Hepatology
  • Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations, 2021, Cancer Cell
  • Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor, 2020, Chemico-Biological Interactions
  • Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors, 2021, Cell Reports

Frequent co-authors in their body of work include:

  • Wendy M. Mars
  • John Stoops
  • Bharat Bhushan
  • Anne Orr
  • William C. Bowen

Publications by George K. Michalopoulos appear regularly in venues such as:

  • American Journal Of Pathology
  • The FASEB Journal
  • Hepatology Communications
  • Hepatology
  • Nature Reviews Gastroenterology & Hepatology

Their main fields of study are medicine and biochemistry, genetics, and molecular biology, with subfields including hepatology, molecular biology, surgery, epidemiology, and cell biology.

The scientist's research topics cover a range of subjects primarily related to liver function and disease. These topics include:

  • Liver physiology and pathology
  • Liver disease diagnosis and treatment
  • Organ transplantation techniques and outcomes
  • Hippo pathway signaling and YAP/TAZ
  • Cholangiocarcinoma and gallbladder cancer studies
  • Cancer-related gene regulation
  • Cancer mechanisms and therapy

Best Publications

  • Liver regeneration: molecular mechanisms of growth control.

    George K. Michalopoulos

  • Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations.

    G. Michalopoulos;H.C. Pitot

  • Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

    L Naldini;E Vigna;R P Narsimhan;G Gaudino

  • Gene Expression Alterations in Prostate Cancer Predicting Tumor Aggression and Preceding Development of Malignancy

    Yan Ping Yu;Douglas Landsittel;Ling Jing;Joel Nelson

  • Liver Regeneration after Partial Hepatectomy: Critical Analysis of Mechanistic Dilemmas

    George K. Michalopoulos

  • Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

    L. Naldini;K.M. Weidner;E. Vigna;G. Gaudino

  • Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.

    G. D. Block;J. Locker;W. C. Bowen;B. E. Petersen

  • The Many Faces of Hepatocyte Growth Factor: from Hepatopoiesis to Hematopoiesis

    Reza Zarnegar;George K. Michalopoulos

  • An Autophagy-Enhancing Drug Promotes Degradation of Mutant α1-Antitrypsin Z and Reduces Hepatic Fibrosis

    Tunda Hidvegi;Michael Ewing;Pamela Hale;Christine Dippold

  • Liver regeneration: biological and pathological mechanisms and implications

    George K. Michalopoulos;Bharat Bhushan

  • Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process.

    Uma R Chandran;Changqing Ma;Rajiv Dhir;Michelle Bisceglia

  • Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

    Reza Zarnegar;George Michalopoulos

  • Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

    W. M. Mars;R. Zarnegar;G. K. Michalopoulos

  • Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat

    Bryon E. Petersen;Julie P. Goff;Joel S. Greenberger;George K. Michalopoulos

  • Hepatostat: Liver regeneration and normal liver tissue maintenance.

    George K. Michalopoulos

  • Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.

    Minji Jo;Donna Beer Stolz;James E. Esplen;Kenneth Dorko

  • Conditional Deletion of β-Catenin Reveals Its Role in Liver Growth and Regeneration

    Xinping Tan;Jaideep Behari;Benjamin Cieply;George K. Michalopoulos

  • Hepatocyte growth factor.

    George K. Michalopoulos;Reza Zarnegar

  • Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas

    Jian-Hua Luo;Baoguo Ren;Sergei Keryanov;George C. Tseng

  • Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury.

    George K. Michalopoulos;Lindsay Barua;William C. Bowen

Frequent Co-Authors

Jian-Hua Luo
Jian-Hua Luo University of Pittsburgh
Donna B. Stolz
Donna B. Stolz University of Pittsburgh
George C. Tseng
George C. Tseng University of Pittsburgh
Satdarshan P. Monga
Satdarshan P. Monga University of Pittsburgh
Stephen C. Strom
Stephen C. Strom Karolinska Institute
Michael A. Nalesnik
Michael A. Nalesnik University of Pittsburgh
Anthony J. Demetris
Anthony J. Demetris University of Pittsburgh
Henry C. Pitot
Henry C. Pitot University of Wisconsin–Madison
Chuanyue Wu
Chuanyue Wu University of Pittsburgh
Tong Wu
Tong Wu Chinese Academy of Sciences

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