2018 - Fellow of the American Academy of Arts and Sciences
David H. Perlmutter mainly investigates Molecular biology, Cell biology, Autophagy, Alpha and Endoplasmic reticulum. His Cell biology research incorporates themes from Secretory protein and Mutant protein. His study looks at the intersection of Autophagy and topics like Cancer research with Immunology, Hepatic fibrosis and Liver injury.
David H. Perlmutter usually deals with Alpha and limits it to topics linked to Alpha 1-antitrypsin deficiency and Phenylbutyrate. His Endoplasmic reticulum study combines topics in areas such as Signal transduction, Mutant, Intracellular and Lactacystin. His research integrates issues of Programmed cell death and Physiology in his study of Autolysosome.
David H. Perlmutter mostly deals with Liver disease, Cell biology, Endoplasmic reticulum, Biochemistry and Alpha 1-antitrypsin deficiency. His studies deal with areas such as Fibrosis, Cirrhosis, Liver injury and Liver transplantation as well as Liver disease. His studies in Cell biology integrate themes in fields like Autophagy, Apoptosis, Fibroblast and Gene expression.
As part of the same scientific family, David H. Perlmutter usually focuses on Autophagy, concentrating on Hepatic fibrosis and intersecting with Carcinogenesis. The concepts of his Endoplasmic reticulum study are interwoven with issues in Proteostasis, Mutant protein, Mutant and Intracellular. His Alpha 1-antitrypsin deficiency study which covers Alpha that intersects with Phenotype.
David H. Perlmutter spends much of his time researching Cell biology, Alpha 1-antitrypsin deficiency, Liver disease, Autophagy and Immunology. His research in Cell biology intersects with topics in Mutant and Caenorhabditis elegans. David H. Perlmutter has researched Mutant in several fields, including Mutation and Molecular biology.
His Liver disease study combines topics from a wide range of disciplines, such as Liver transplantation, Transplantation, Heart transplantation, Cirrhosis and Pathology. His Autophagy research includes elements of Hepatocellular carcinoma, Cancer research, Programmed cell death and Hepatic fibrosis. His Endoplasmic reticulum research is multidisciplinary, relying on both Serpin and Intracellular.
His scientific interests lie mostly in Immunology, Alpha 1-antitrypsin deficiency, Cell biology, Liver transplantation and Liver disease. His studies in Immunology integrate themes in fields like Cancer research, Liver injury, Hepatic fibrosis and Hepatocyte. His research in Alpha 1-antitrypsin deficiency intersects with topics in Endoplasmic reticulum and Intracellular.
His research links Mutant with Cell biology. David H. Perlmutter works mostly in the field of Liver transplantation, limiting it down to topics relating to Neutrophil elastase and, in certain cases, Cathepsin G, as a part of the same area of interest. David H. Perlmutter interconnects Genetics and Computational biology in the investigation of issues within Drug discovery.
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Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal.
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
D H Perlmutter;C A Dinarello;P I Punsal;H R Colten.
Journal of Clinical Investigation (1986)
An Autophagy-Enhancing Drug Promotes Degradation of Mutant α1-Antitrypsin Z and Reduces Hepatic Fibrosis
Tunda Hidvegi;Michael Ewing;Pamela Hale;Christine Dippold.
Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency.
Jon A. J. Burrows;Lauren K. Willis;David H. Perlmutter.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Biliary atresia: Current concepts and research directions. Summary of a symposium
W F Balistreri;R Grand;J H Hoofnagle;F J Suchy.
Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity
Dongfeng Qu;Jeffrey H. Teckman;Satoshi Omura;David H. Perlmutter.
Journal of Biological Chemistry (1996)
Functions of autophagy in normal and diseased liver
Mark J. Czaja;Wen Xing Ding;Terrence M. Donohue;Scott L. Friedman.
A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency
Ying Wu;Ina Whitman;Ernesto Molmenti;Kenneth Moore.
Proceedings of the National Academy of Sciences of the United States of America (1994)
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