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D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
37744
World Ranking
5189
National Ranking
2467

Research.com Recognitions

  • 2018 - Fellow of the American Academy of Arts and Sciences

Overview

David H. Perlmutter is affiliated with Washington University in St. Louis in the United States. Their research spans the intersection of biochemistry, genetics, molecular biology, and medicine, with a strong focus on molecular and cell biology as well as epidemiology and neurology. Their work often addresses complex biological processes and disease mechanisms.

The scientist's primary fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields particularly emphasized in their research are:

  • Molecular Biology
  • Cell Biology
  • Epidemiology
  • Neurology
  • Electrical and Electronic Engineering

Research topics explored include:

  • Endoplasmic Reticulum Stress and Disease
  • Autophagy in Disease and Therapy
  • Mitochondrial Function and Pathology
  • Ubiquitin and Proteasome Pathways
  • CRISPR and Genetic Engineering
  • Genetic Neurodegenerative Diseases
  • Neurological Disorders and Treatments

Recent papers published by David H. Perlmutter reflect a range of biomedical and computational research themes. These include:

  • "Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy" (2022, Nature Neuroscience)
  • "Detecting lithium plating dynamics in a solid-state battery with operando X-ray computed tomography using machine learning" (2023, npj Computational Materials)
  • "Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency" (2024, Hepatology)
  • "Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency" (2023, Hepatology Communications)
  • "A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy" (2024, Autophagy Reports)

Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Neuroscience
  • npj Computational Materials
  • Hepatology
  • Autophagy Reports

David H. Perlmutter has collaborated most frequently with several coauthors:

  • Stephen C. Pak
  • Gary A. Silverman
  • Roland E. Dolle
  • Andrew S. Yoo
  • Daniela Ushizima

Recognition of their work includes the appointment as a Fellow of the American Academy of Arts and Sciences in 2018.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

    D H Perlmutter;C A Dinarello;P I Punsal;H R Colten

  • An Autophagy-Enhancing Drug Promotes Degradation of Mutant α1-Antitrypsin Z and Reduces Hepatic Fibrosis

    Tunda Hidvegi;Michael Ewing;Pamela Hale;Christine Dippold

  • Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency.

    Jon A. J. Burrows;Lauren K. Willis;David H. Perlmutter

  • Functions of autophagy in normal and diseased liver

    Mark J. Czaja;Wen Xing Ding;Terrence M. Donohue;Scott L. Friedman

  • Biliary atresia: Current concepts and research directions. Summary of a symposium

    W F Balistreri;R Grand;J H Hoofnagle;F J Suchy

  • Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity

    Dongfeng Qu;Jeffrey H. Teckman;Satoshi Omura;David H. Perlmutter

  • A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency

    Ying Wu;Ina Whitman;Ernesto Molmenti;Kenneth Moore

  • Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung.

    D. L. Haviland;R. L. McCoy;W. T. Whitehead;H. Akama

  • Intracellular Inclusions Containing Mutant α1-Antitrypsin Z Are Propagated in the Absence of Autophagic Activity

    Takahiro Kamimoto;Shisako Shoji;Shisako Shoji;Shisako Shoji;Tunda Hidvegi;Noboru Mizushima;Noboru Mizushima;Noboru Mizushima

  • Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking.

    David H Perlmutter

  • Evidence for an acute phase response in human intestinal epithelial cells.

    E.P. Molmenti;T. Ziambaras;D.H. Perlmutter

  • Retention of mutant α1-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response

    Jeffrey H. Teckman;David H. Perlmutter

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

    Itender Singh;Abhay P. Sagare;Mireia Coma;David Perlmutter

  • Accumulation of Mutant α1-Antitrypsin Z in the Endoplasmic Reticulum Activates Caspases-4 and -12, NFκB, and BAP31 but Not the Unfolded Protein Response

    Tunda Hidvegi;Bela Z. Schmidt;Pamela Hale;David H. Perlmutter

  • Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes

    David H. Perlmutter;George I. Glover;Meheryar Rivetna;Charles S. Schasteen

Frequent Co-Authors

Gary A. Silverman
Gary A. Silverman Washington University in St. Louis
Harvey R. Colten
Harvey R. Colten Washington University in St. Louis
Evelina Gatti
Evelina Gatti Aix-Marseille University
Noboru Mizushima
Noboru Mizushima University of Tokyo
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Sergio Lavandero
Sergio Lavandero University of Chile
Ivet Bahar
Ivet Bahar University of Pittsburgh
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Donna B. Stolz
Donna B. Stolz University of Pittsburgh
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine

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