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Medicine

D-Index
97
Citations
31049
World Ranking
9378
National Ranking
4836

Overview

Youhua Liu is affiliated with the University of Pittsburgh in the United States. Their research spans a range of topics primarily within Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Nephrology, Surgery, Immunology, and Pulmonary and Respiratory Medicine.

Their scientific contributions explore several key topics in kidney-related diseases and molecular signaling pathways, including:

  • Chronic Kidney Disease and Diabetes
  • Renal and related cancers
  • Renal Diseases and Glomerulopathies
  • Acute Kidney Injury Research
  • Epigenetics and DNA Methylation
  • Renal and Vascular Pathologies
  • Wnt/β-catenin signaling in development and cancer

Their recent papers reflect these research interests, featuring publications such as:

  • "The fibrogenic niche in kidney fibrosis: components and mechanisms" (2022) published in Nature Reviews Nephrology
  • "LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence" (2021) published in Frontiers in Cell and Developmental Biology
  • "A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling" (2022) published in Nature Communications
  • "Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies" (2020) published in Frontiers in Pharmacology
  • "Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/β-catenin signaling" (2022) published in Kidney International

They have frequently published in respected venues, including:

  • Kidney International
  • Journal of the American Society of Nephrology
  • Theranostics
  • Research Square
  • Nature Communications

Collaboration is a significant aspect of their work, with regular coauthors comprising:

  • Lili Zhou
  • Fan Fan Hou
  • Haiyan Fu
  • Xue Hong
  • Jinhua Miao

The research profile of Youhua Liu indicates a sustained focus on understanding molecular mechanisms underlying kidney pathology and potential therapeutic strategies. Their work on signaling pathways such as Wnt/β-catenin and the role of peptides derived from Klotho reflects ongoing efforts to address renal fibrosis and diabetic kidney disease.

Best Publications

  • Epithelial to Mesenchymal Transition in Renal Fibrogenesis: Pathologic Significance, Molecular Mechanism, and Therapeutic Intervention

    Youhua Liu

  • Renal fibrosis: New insights into the pathogenesis and therapeutics

    Youhua Liu

  • Cellular and molecular mechanisms of renal fibrosis

    Youhua Liu

  • Dissection of Key Events in Tubular Epithelial to Myofibroblast Transition and Its Implications in Renal Interstitial Fibrosis

    Junwei Yang;Youhua Liu

  • New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

    Youhua Liu

  • Wnt/β-Catenin Signaling Promotes Renal Interstitial Fibrosis

    Weichun He;Chunsun Dai;Yingjian Li;Gang Zeng

  • Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.

    Yingjian Li;Junwei Yang;Chunsun Dai;Chuanyue Wu

  • Blockage of Tubular Epithelial to Myofibroblast Transition by Hepatocyte Growth Factor Prevents Renal Interstitial Fibrosis

    Junwei Yang;Youhua Liu

  • Wnt/β-Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria

    Chunsun Dai;Donna B. Stolz;Lawrence P. Kiss;Satdarshan P. Monga

  • Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.

    Yingjian Li;Young Sun Kang;Chunsun Dai;Lawrence P. Kiss

  • Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling

    Lili Zhou;Yingjian Li;Dong Zhou;Roderick J. Tan

  • Paricalcitol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy

    Xiaoyue Tan;Yingjian Li;Youhua Liu

  • Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action.

    Youhua Liu

  • Paricalcitol Inhibits Renal Inflammation by Promoting Vitamin D Receptor–Mediated Sequestration of NF-κB Signaling

    Xiaoyue Tan;Xiaoyan Wen;Youhua Liu

  • Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy

    Junwei Yang;Ryan W. Shultz;Wendy M. Mars;Rodney E. Wegner

  • Blockade of Wnt/β-Catenin Signaling by Paricalcitol Ameliorates Proteinuria and Kidney Injury

    Weichun He;Young Sun Kang;Chunsun Dai;Youhua Liu

  • Matrix metalloproteinases in kidney homeostasis and diseases

    Roderick J. Tan;Youhua Liu

  • Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation.

    Jing-Lin Xia;Chunsun Dai;George K. Michalopoulos;Youhua Liu

  • Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.

    Kebin Hu;Junwei Yang;Sakae Tanaka;Steven L. Gonias

  • A Novel Mechanism by which Hepatocyte Growth Factor Blocks Tubular Epithelial to Mesenchymal Transition

    Junwei Yang;Chunsun Dai;Youhua Liu

Frequent Co-Authors

George K. Michalopoulos
George K. Michalopoulos University of Pittsburgh
Chuanyue Wu
Chuanyue Wu University of Pittsburgh
Donna B. Stolz
Donna B. Stolz University of Pittsburgh
Satdarshan P. Monga
Satdarshan P. Monga University of Pittsburgh
Wen Xie
Wen Xie University of Pittsburgh
Christopher S. Wilcox
Christopher S. Wilcox Georgetown University
Lawrence B. Holzman
Lawrence B. Holzman University of Pennsylvania
Tong Wu
Tong Wu Chinese Academy of Sciences
Shoukat Dedhar
Shoukat Dedhar University of British Columbia
Klaus H. Kaestner
Klaus H. Kaestner University of Pennsylvania

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