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Overview

Hui-Yao Lan is affiliated with the Chinese University of Hong Kong in China, contributing extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans various subfields, prominently including molecular biology, nephrology, immunology, oncology, and cancer research.

The scientist's work covers several main topics, notably:

  • Chronic Kidney Disease and Diabetes
  • TGF-β signaling in diseases
  • Renal and related cancers
  • Immune cells in cancer
  • Acute Kidney Injury Research
  • Cancer-related molecular mechanisms research
  • Epigenetics and DNA Methylation

Hui-Yao Lan has published research in multiple peer-reviewed journals with high frequency in venues such as:

  • Clinical and Experimental Pharmacology and Physiology
  • International Journal of Biological Sciences
  • Advanced Science
  • Molecular Therapy
  • Journal of the American Society of Nephrology

Recent notable publications include:

  • Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury, 2021, Theranostics
  • Diverse Role of TGF-β in Kidney Disease, 2020, Frontiers in Cell and Developmental Biology
  • GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy, 2021, Cell Death and Differentiation
  • Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage-Myofibroblast Transition, 2021, Advanced Science
  • TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment, 2021, International Journal of Molecular Sciences

Collaborations with frequent co-authors have formed a significant part of Hui-Yao Lan's research output. These co-authors include Xiao-Ru Huang, Patrick Ming-Kuen Tang, Xueqing Yu, Ka-Fai To, and Junzhe Chen.

The scientist's research largely contributes to the understanding of kidney diseases, particularly chronic and acute kidney injury, as well as cancer biology related to renal tissues. A substantial focus is placed on TGF-β signaling pathways, immune cell involvement in cancer, and molecular mechanisms underpinning fibrosis, inflammation, and tumor microenvironments.

Best Publications

  • TGF-β: the master regulator of fibrosis

    Xiao Ming Meng;David J. Nikolic-Paterson;Hui Yao Lan

  • Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism

    Marilda Mazzali;Jeremy Hughes;Yoon Goo Kim;J. Ashley Jefferson

  • Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism

    Marilda Mazzali;John Kanellis;Lin Han;Lili Feng

  • Uric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2

    John Kanellis;Susumu Watanabe;Jinhua Li;Duk Hee Kang

  • Uric Acid, Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity

    Susumu Watanabe;Duk Hee Kang;Lili Feng;Takahiko Nakagawa

  • Transforming growth factor-β regulates tubular epithelial-myofibroblast transdifferentiation in vitro

    Jun-Ming Fan;Yee-Yung Ng;Prudence A. Hill;David J. Nikolic-Paterson

  • Diverse roles of TGF-β/Smads in renal fibrosis and inflammation.

    Hui Yao Lan

  • Macrophages: versatile players in renal inflammation and fibrosis

    Patrick Ming Kuen Tang;David J. Nikolic-Paterson;Hui Yao Lan

  • Renal tubule injury: a driving force toward chronic kidney disease.

    Bi-Cheng Liu;Tao-Tao Tang;Lin-Li Lv;Hui-Yao Lan

  • TGF-β/Smad signaling in renal fibrosis

    Xiao-Ming Meng;Patrick Ming-Kuen Tang;Jun Li;Hui Yao Lan

  • Inflammatory processes in renal fibrosis.

    Xiao-Ming Meng;David J Nikolic-Paterson;Hui Yao Lan

  • TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

    Wei Qin;Arthur C.K. Chung;Xiao R. Huang;Xiao-Ming Meng

  • A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

    Roberta Pang;Wai Lun Law;Andrew C.Y. Chu;Jensen T. Poon

  • Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats

    Yee-Yung Ng;Tung-Po Huang;Tung-Po Huang;Wu-Chang Yang;Wu-Chang Yang;Zheng-Ping Chen;Zheng-Ping Chen

  • Transforming growth factor-beta and Smad signalling in kidney diseases.

    Wansheng Wang;Vijay Koka;Hui Y Lan

  • Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis

    Xiang Zhong;Arthur Chi Kong Chung;Hai-Yong Chen;Xiaoming Meng

  • Inhibition of Renal Fibrosis by Gene Transfer of Inducible Smad7 Using Ultrasound-Microbubble System in Rat UUO Model

    Hui Y Lan;Wei Mu;Naruya Tomita;Xiao R Huang

  • Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation.

    Jinhua Li;Hong-Jian Zhu;Xiao R Huang;Kar N Lai

  • miR-192 Mediates TGF-β/Smad3-Driven Renal Fibrosis

    Arthur C.K. Chung;Xiao R. Huang;Xiaoming Meng;Hui Y. Lan

  • Role of the TGF-β/BMP-7/Smad pathways in renal diseases

    Xiao-Ming Meng;Arthur C. K. Chung;Hui Y. Lan

Frequent Co-Authors

Ka-Fai To
Ka-Fai To Chinese University of Hong Kong
Yu Huang
Yu Huang University of California, Los Angeles
Ronald C.W. Ma
Ronald C.W. Ma Chinese University of Hong Kong
Cheuk-Chun Szeto
Cheuk-Chun Szeto Chinese University of Hong Kong
Hong Jiang
Hong Jiang Nanjing Tech University
Juliana C.N. Chan
Juliana C.N. Chan Chinese University of Hong Kong
David J. Nikolic-Paterson
David J. Nikolic-Paterson Monash Medical Centre
Wing-Yee So
Wing-Yee So Chinese University of Hong Kong
Jianguo Wu
Jianguo Wu Jinan University
Jun Yu
Jun Yu Chinese University of Hong Kong

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