What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Internal medicine
His main research concerns Podocyte, Nephrin, Cell biology, Molecular biology and Slit diaphragm.
Lawrence B. Holzman interconnects Glomerulosclerosis and Glomerular basement membrane, Glomerulonephritis in the investigation of issues within Podocyte.
As part of the same scientific family, Lawrence B. Holzman usually focuses on Nephrin, concentrating on Renal glomerulus and intersecting with Renal function and Glomerulus.
The concepts of his Cell biology study are interwoven with issues in Lamellipodium and Immunology.
His biological study spans a wide range of topics, including Tumor necrosis factor alpha, Protein structure, Gene expression and Immunoprecipitation.
His work investigates the relationship between Gene expression and topics such as Transgene that intersect with problems in Kidney.
His most cited work include:
- Podocyte Depletion Causes Glomerulosclerosis: Diphtheria Toxin–Induced Podocyte Depletion in Rats Expressing Human Diphtheria Toxin Receptor Transgene (532 citations)
- Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin (493 citations)
- Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. (435 citations)
What are the main themes of his work throughout his whole career to date?
Lawrence B. Holzman mostly deals with Podocyte, Cell biology, Nephrin, Internal medicine and Slit diaphragm.
His study in Podocyte is interdisciplinary in nature, drawing from both Glomerulosclerosis, Glomerular basement membrane and Immunology.
His Cell biology study incorporates themes from Glomerular Filtration Barrier and Actin cytoskeleton.
His work in Nephrin tackles topics such as Molecular biology which are related to areas like Genetically modified mouse, Transgene, Gene and Gene expression.
Within one scientific family, Lawrence B. Holzman focuses on topics pertaining to Cancer research under Slit diaphragm, and may sometimes address concerns connected to Phenotype.
His research investigates the connection between Podocin and topics such as Synaptopodin that intersect with problems in Cortactin and Immortalised cell line.
He most often published in these fields:
- Podocyte (67.79%)
- Cell biology (61.74%)
- Nephrin (36.91%)
What were the highlights of his more recent work (between 2014-2021)?
- Internal medicine (24.83%)
- Minimal change disease (8.05%)
- Focal segmental glomerulosclerosis (12.08%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Internal medicine, Minimal change disease, Focal segmental glomerulosclerosis, Nephrotic syndrome and Podocyte.
His Internal medicine study combines topics in areas such as Endocrinology and Intensive care medicine.
His Nephrotic syndrome research is multidisciplinary, relying on both Apolipoprotein L1, Genotype, Cancer research and Proteinuria.
He combines subjects such as Pathogenesis and Cell biology with his study of Podocyte.
His research integrates issues of Biochemistry and Binding site in his study of Cell biology.
The various areas that he examines in his Nephrin study include Phosphatase, Phosphorylation and Glomerular basement membrane.
Between 2014 and 2021, his most popular works were:
- A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease (88 citations)
- An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome. (67 citations)
- Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys (59 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Enzyme
- Internal medicine
His primary scientific interests are in Internal medicine, Digital pathology, Pathology, Focal segmental glomerulosclerosis and Minimal change disease.
His Internal medicine study combines topics from a wide range of disciplines, such as Gastroenterology and Endocrinology.
His study in the field of Glomerular basement membrane, Glomerulopathy and Nephrin is also linked to topics like Kidney development.
His work on Surgical pathology and Translational research as part of general Pathology research is often related to Data science and International scale, thus linking different fields of science.
His studies in Focal segmental glomerulosclerosis integrate themes in fields like Genome-wide association study, Expression quantitative trait loci, Human leukocyte antigen, Allele and Computational biology.
Lawrence B. Holzman has included themes like Podocyte, Membranous nephropathy and Renal biopsy in his Nephrotic syndrome study.
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