Harinder S. Hundal mainly investigates Biochemistry, Internal medicine, Endocrinology, Akt/PKB signaling pathway and Glycogen synthase. The study incorporates disciplines such as Function and Cell biology in addition to Biochemistry. His study connects Protein kinase A and Internal medicine.
Harinder S. Hundal interconnects GSK-3 and ASK1 in the investigation of issues within Akt/PKB signaling pathway. In his study, Myocyte is strongly linked to Glucose uptake, which falls under the umbrella field of Glucose transporter. His biological study spans a wide range of topics, including Effector, Intracellular and Amino acid transporter.
Harinder S. Hundal spends much of his time researching Endocrinology, Internal medicine, Biochemistry, Skeletal muscle and Cell biology. His work carried out in the field of Endocrinology brings together such families of science as Protein kinase B and Wortmannin. Harinder S. Hundal works mostly in the field of Protein kinase B, limiting it down to topics relating to Protein kinase C and, in certain cases, IRS1, as a part of the same area of interest.
His Internal medicine research incorporates elements of Diabetes mellitus and Protein kinase A. His Skeletal muscle research is multidisciplinary, incorporating elements of Glucose transporter, Myocyte and GLUT5. His study looks at the intersection of MAP kinase kinase kinase and topics like Akt/PKB signaling pathway with GSK-3.
His primary areas of investigation include Internal medicine, Endocrinology, Cell biology, Skeletal muscle and Insulin resistance. In his study, which falls under the umbrella issue of Internal medicine, Obesity is strongly linked to Diabetes mellitus. His research ties Biochemistry and Cell biology together.
His Skeletal muscle research is multidisciplinary, incorporating perspectives in Myocyte and Polyunsaturated fatty acid. His Insulin resistance study is associated with Insulin. His research in Insulin intersects with topics in Protein kinase B and Energy homeostasis.
The scientist’s investigation covers issues in Biochemistry, Cell biology, Signal transduction, Skeletal muscle and Phosphorylation. His study in the fields of Unsaturated fatty acid, Amino acid and Linoleic acid under the domain of Biochemistry overlaps with other disciplines such as Cellular stress response. His research integrates issues of Glucose transporter and Insulin resistance in his study of Cell biology.
Internal medicine and Endocrinology are the two main areas of interest in his Skeletal muscle studies. His Internal medicine research integrates issues from AMP-activated protein kinase, AMPK and Protein kinase A. Harinder S. Hundal has included themes like Atrophy, Function and Ageing in his Endocrinology study.
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The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
D A E Cross;D R Alessi;J R Vandenheede;H E McDowell.
Biochemical Journal (1994)
Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism
Darren J. Powell;Eric Hajduch;Gursant Kular;Harinder S. Hundal.
Molecular and Cellular Biology (2003)
Amino acid transporters: roles in amino acid sensing and signalling in animal cells
Russell Hyde;Peter M. Taylor;Harinder S. Hundal.
Biochemical Journal (2003)
Protein kinase B (PKB/Akt) – a key regulator of glucose transport?
Eric Hajduch;Gary J Litherland;Harinder S Hundal.
FEBS Letters (2001)
Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.
H S Hundal;T Ramlal;R Reyes;L A Leiter.
Endocrinology (1992)
Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling.
Harinder Singh Hundal;Peter Maving Taylor.
American Journal of Physiology-endocrinology and Metabolism (2009)
Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
Darren J. Powell;Sophie Turban;Alexander Gray;Eric Hajduch.
Biochemical Journal (2004)
Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.
H.S. Hundal;A Marette;Y Mitsumoto;T Ramlal.
Journal of Biological Chemistry (1992)
L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport.
Karine Peyrollier;Eric Hajduch;Anne S. Blair;Russell Hyde.
Biochemical Journal (2000)
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.
E. Hajduch;A. Balendran;I. H. Batty;G. J. Litherland.
Diabetologia (2001)
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