Harinder S. Hundal

Overview

Best Publications

• The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

  D A E Cross;D R Alessi;J R Vandenheede;H E McDowell

  706
  Citations

• Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

  E Hajduch;D R Alessi;B A Hemmings;H S Hundal

  486
  Citations

• Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism

  Darren J. Powell;Eric Hajduch;Gursant Kular;Harinder S. Hundal

  433
  Citations

• Amino acid transporters: roles in amino acid sensing and signalling in animal cells

  Russell Hyde;Peter M. Taylor;Harinder S. Hundal

  430
  Citations

• Protein kinase B (PKB/Akt) – a key regulator of glucose transport?

  Eric Hajduch;Gary J Litherland;Harinder S Hundal

  384
  Citations

• Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling.

  Harinder Singh Hundal;Peter Maving Taylor

  347
  Citations

• Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.

  H S Hundal;T Ramlal;R Reyes;L A Leiter

  333
  Citations

• Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

  Darren J. Powell;Sophie Turban;Alexander Gray;Eric Hajduch

  320
  Citations

• Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.

  H.S. Hundal;A Marette;Y Mitsumoto;T Ramlal

  310
  Citations

• Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

  Nikolaos Dimopoulos;Maria Watson;Kei Sakamoto;Harinder S. Hundal

  304
  Citations

• L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport.

  Karine Peyrollier;Eric Hajduch;Anne S. Blair;Russell Hyde

  294
  Citations

• Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

  E. Hajduch;A. Balendran;I. H. Batty;G. J. Litherland

  286
  Citations

• Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection, and chronic disease.

  M.J Rennie;P Babij;P.M Taylor;H.S Hundal

  252
  Citations

• Regulation of Glucose Transport and Glycogen Synthesis in L6 Muscle Cells during Oxidative Stress EVIDENCE FOR CROSS-TALK BETWEEN THE INSULIN AND SAPK2/p38 MITOGEN-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS

  Anne S. Blair;Eric Hajduch;Gary J. Litherland;Harinder S. Hundal

  246
  Citations

• Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.

  L G Fryer;E Hajduch;F Rencurel;I P Salt

  243
  Citations

• Lipid modulation of skeletal muscle mass and function.

  Christopher Lipina;Harinder S Hundal

  224
  Citations

• Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.

  T Tsakiridis;H E McDowell;T Walker;C P Downes

  220
  Citations

• Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability.

  Russell Hyde;Emma L. Cwiklinski;Katrina MacAulay;Peter M. Taylor

  170
  Citations

• Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

  Charlotte J. Green;Olga Göransson;Gursant S. Kular;Nick R. Leslie

  167
  Citations

• Serotonin (5-Hydroxytryptamine), a Novel Regulator of Glucose Transport in Rat Skeletal Muscle *

  E Hajduch;F Rencurel;A Balendran;I H Batty

  157
  Citations