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Biology and Biochemistry

D-Index
86
Citations
24074
World Ranking
3005
National Ranking
224

Overview

Alan R. Prescott is affiliated with the University of Dundee in the United Kingdom. Their research expertise spans Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine. Subfields of their work include Molecular Biology, Epidemiology, Neurology, Cell Biology, and Physiology.

The primary topics of Prescott's work encompass:

  • Autophagy in Disease and Therapy
  • Parkinson's Disease Mechanisms and Treatments
  • Ubiquitin and proteasome pathways
  • Lysosomal Storage Disorders Research
  • Cellular transport and secretion
  • Mitochondrial Function and Pathology
  • Pluripotent Stem Cells Research

Prescott has published numerous papers in a variety of scientific journals. Notable recent publications include:

  • "Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice", 2021, eLife
  • "Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding", 2022, Biochemical Journal
  • "A conserved ATG2-GABARAP family interaction is critical for phagophore formation", 2020, EMBO Reports
  • "Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1", 2021, Science Advances
  • "Antibody RING-Mediated Destruction of Endogenous Proteins", 2020, Molecular Cell

Frequent collaborators include François Singh, Ian G. Ganley, Odetta Antico, Rachel Toth, and Miratul M. K. Muqit.

Prescott's work has been frequently published in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Journal of Cell Science
  • Biochemical Journal
  • EMBO Reports

In addition to journal publications, Prescott has contributed to academic books. One such work is Para-Site-Seeing, published by University of Dundee eBooks in 2020.

Best Publications

  • Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling

    Michele A. West;Robert P. A. Wallin;Robert P. A. Wallin;Robert P. A. Wallin;Stephen P. Matthews;Henrik G. Svensson

  • AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

    I Salt;J W Celler;S A Hawley;A Prescott

  • MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

    Jérôme Boudeau;Annette F. Baas;Maria Deak;Nick A. Morrice

  • Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

    Christopher C. Norbury;Lindsay J. Hewlett;Alan R. Prescott;Nilabh Shastri

  • Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.

    Thomas G. McWilliams;Alan R. Prescott;Lambert Montava-Garriga;Graeme Ball

  • The coated pit and macropinocytic pathways serve distinct endosome populations

    Lindsay J. Hewlett;Alan R. Prescott;Colin Watts

  • Constitutive macropinocytosis allows TAP-dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells

    Christopher C. Norbury;Benedict J. Chambers;Alan R. Prescott;Hans Gustaf Ljunggren

  • Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

    Xianming Deng;Nicolas Dzamko;Alan Prescott;Paul Davies

  • Intermediate filament interactions can be altered by HSP27 and alphaB-crystallin

    M D Perng;Lindsay Susan Cairns;P van den IJssel;A Prescott

  • mito-QC illuminates mitophagy and mitochondrial architecture in vivo

    Thomas G. McWilliams;Alan R. Prescott;George F.G. Allen;Jevgenia Tamjar

  • 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    R. Jeremy Nichols;Nicolas Dzamko;Nicholas A. Morrice;David G. Campbell

  • Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

    Nicolas Dzamko;Maria Deak;Faycal Hentati;Alastair D. Reith

  • Essential role of PDK1 in regulating cell size and development in mice.

    Margaret A. Lawlor;Alfonso Mora;Peter R. Ashby;Michayla R. Williams

  • Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome

    Dawn H. Siegel;Gabrielle H.S. Ashton;Homero G. Penagos;James V. Lee

  • Molecular mechanisms of kinetochore capture by spindle microtubules

    Kozo Tanaka;Naomi Mukae;Hilary Dewar;Mark van Breugel

  • Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

    Ruzica Bago;Nazma Malik;Michael J. Munson;Alan R. Prescott

  • BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

    Laura Hobley;Adam Ostrowski;Francesco V. Rao;Keith M. Bromley

  • Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation.

    Michele A. West;Alan R. Prescott;Eeva-Liisa Eskelinen;Anne J. Ridley

  • Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.

    Kearsey Jm;Coates Pj;Prescott Ar;Warbrick E

  • Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.

    Graham Rena;Alan R. Prescott;Shaodong Guo;Philip Cohen

Frequent Co-Authors

Roy A. Quinlan
Roy A. Quinlan Durham University
Dario R. Alessi
Dario R. Alessi University of Dundee
Colin Watts
Colin Watts University of Birmingham
Maria Deak
Maria Deak University of Dundee
Angus I. Lamond
Angus I. Lamond University of Dundee
Michael A. J. Ferguson
Michael A. J. Ferguson University of Dundee
John M. Lucocq
John M. Lucocq University of St Andrews
Rachel Toth
Rachel Toth University of Dundee
Philip Cohen
Philip Cohen University of Dundee
Matthias Trost
Matthias Trost Newcastle University

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