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Biology and Biochemistry

D-Index
63
Citations
12057
World Ranking
10386
National Ranking
792

Overview

Roy A. Quinlan is affiliated with Durham University in the United Kingdom and has a substantial body of research focused primarily on biochemistry, genetics, and molecular biology. Their publications reflect an interdisciplinary approach connecting molecular biology, ophthalmology, cell biology, genetics, and imaging sciences.

The scientist's research topics include:

  • Connexins and lens biology
  • Intraocular surgery and lenses
  • RNA regulation and disease
  • Yersinia bacterium, plague, and ectoparasites research
  • Skin and cellular biology research
  • Heat shock proteins research
  • Endoplasmic reticulum stress and disease

Quinlan has frequently collaborated with several researchers in their field. The most common co-authors include:

  • Vanita Berry
  • Michel Michaelides
  • Nikolas Pontikos
  • Alexia A. Kalligeraki
  • Anthony T. Moore

The primary publication venues where Quinlan's work appears most often are:

  • Ophthalmic Genetics
  • Cell Stress and Chaperones
  • Genes
  • Experimental Eye Research
  • Cells

Notable recent papers authored or co-authored by Quinlan include:

  • "Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches," 2020, British Journal of Ophthalmology
  • "The genetic landscape of crystallins in congenital cataract," 2020, Orphanet Journal of Rare Diseases
  • "Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens," 2022, Journal of Biological Chemistry
  • "The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation," 2023, Current Opinion in Cell Biology
  • "Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes in epithelial cell organization," 2020, Scientific Reports

Their work intersects multiple subfields such as molecular biology, ophthalmology, cell biology, genetics, as well as radiology, nuclear medicine, and imaging. This diverse expertise supports a multidisciplinary understanding of eye biology and related genetic conditions.

Best Publications

  • Chaperone activity of alpha-crystallins modulates intermediate filament assembly.

    I D Nicholl;R A Quinlan

  • Patterns of Expression and Organization of Cytokeratin Intermediate Filaments

    Roy A. Quinlan;Dorothea L. Schiller;Mechthild Hatzfeld;Thomas Achtstätter

  • Intermediate filament interactions can be altered by HSP27 and alphaB-crystallin

    M D Perng;Lindsay Susan Cairns;P van den IJssel;A Prescott

  • Alpha-b crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans

    Vanita Berry;Peter Francis;M. Ashwin Reddy;Dean Collyer

  • Lamin A/C Binding Protein LAP2α Is Required for Nuclear Anchorage of Retinoblastoma Protein

    Ewa Markiewicz;Thomas Dechat;Roland Foisner;Roy. A Quinlan

  • [34] Separation of cytokeratin polypeptides by gel electrophoretic and chromatographic techniques and their identification by immunoblotting

    Thomas Achtstaetter;Mechthild Hatzfeld;Roy A. Quinlan;David C. Parmelee

  • Identification of a distinct soluble subunit of an intermediate filament protein: tetrameric vimentin from living cells.

    Peter Soellner;Roy A. Quinlan;Werner W. Franke

  • Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease.

    Rong Li;Anne B. Johnson;Gajja Salomons;James E. Goldman

  • GFAP and its role in Alexander disease.

    Roy A. Quinlan;Michael Brenner;James E. Goldman;Albee Messing

  • Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6

    Dirk A. Kleinjan;Anne Seawright;Andreas Schedl;Roy A Quinlan

  • Heterotypic tetramer (A2D2) complexes of non-epidermal keratins isolated from cytoskeletons of rat hepatocytes and hepatoma cells.

    Roy A. Quinlan;Jeffrey A. Cohlberg;Dorothea L. Schiller;Mechthtld Hatzfeld

  • Comparison of the small heat shock proteins αB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle

    Nikola Golenhofen;Ming Der Perng;Roy A. Quinlan;Detlev Drenckhahn

  • Heteropolymer filaments of vimentin and desmin in vascular smooth muscle tissue and cultured baby hamster kidney cells demonstrated by chemical crosslinking.

    Roy A. Quinlan;Werner W. Franke

  • The growing world of small heat shock proteins: from structure to functions

    Serena Carra;Simon Alberti;Patrick A. Arrigo;Patrick A. Arrigo;Justin L. Benesch

  • Molecular Interactions in Intermediate‐Sized Filaments Revealed by Chemical Cross‐Linking: Heteropholymers of Vimentin and Glial Filament Protein in Cultured Human Glima Cells

    Roy A. Quinlan;Werner W. Franke

  • The Cardiomyopathy and Lens Cataract Mutation in αB-crystallin Alters Its Protein Structure, Chaperone Activity, and Interaction with Intermediate Filaments in Vitro

    Ming Der Perng;Paul J. Muchowski;Paul van den IJssel;Gabrielle J.S. Wu

  • Functions of the intermediate filament cytoskeleton in the eye lens

    Shuhua Song;Andrew Landsbury;Ralf Dahm;Yizhi Liu

  • The Alexander Disease–Causing Glial Fibrillary Acidic Protein Mutant, R416W, Accumulates into Rosenthal Fibers by a Pathway That Involves Filament Aggregation and the Association of αB-Crystallin and HSP27

    Ming Der Perng;Mu Su;Shu Fang Wen;Rong Li

  • Altered aggregation properties of mutant γ-crystallins cause inherited cataract

    Aileen Sandilands;Aileen M. Hutcheson;Heather A. Long;Alan R. Prescott

  • Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research.

    Elizabeth A. Ainsbury;Stephen Barnard;Scott Bright;Claudia Dalke

Frequent Co-Authors

Alan R. Prescott
Alan R. Prescott University of Dundee
Anthony T. Moore
Anthony T. Moore University of California, San Francisco
Jochen Graw
Jochen Graw Technical University of Munich
Werner W. Franke
Werner W. Franke German Cancer Research Center
Murray Stewart
Murray Stewart MRC Laboratory of Molecular Biology
James E. Goldman
James E. Goldman Columbia University
Albee Messing
Albee Messing University of Wisconsin–Madison
E. B. Lane
E. B. Lane Agency for Science, Technology and Research
Michael Brenner
Michael Brenner University of Alabama at Birmingham
Robert D. Moir
Robert D. Moir Harvard University

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