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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
9303
World Ranking
13441
National Ranking
5704

Overview

John I. Clark is affiliated with the University of Washington in the United States and has an extensive research background primarily in biochemistry, genetics, molecular biology, and medicine. Their work covers several subfields including molecular biology, clinical biochemistry, physiology, pharmacology, and ophthalmology.

The scientist has contributed significantly to topics such as connexins and lens biology, advanced glycation end products research, Alzheimer's disease research and treatments, cannabis and cannabinoid research, intraocular surgery and lenses, as well as sleep and wakefulness disorders.

Recent publications by John I. Clark include the following:

  • Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens, 2022, Journal of Biological Chemistry
  • Alzheimer's disease amyloid-β pathology in the lens of the eye, 2022, Experimental Eye Research
  • Age-related loss of auditory sensitivity in the zebrafish (Danio rerio), 2021, Hearing Research
  • Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study, 2024, Journal of Clinical Sleep Medicine
  • In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome, 2024, Experimental Eye Research

Frequent coauthors in their research include Juliet A. Moncaster, Olga Minaeva, Lee E. Goldstein, Rudolph E. Tanzi, and Robert D. Moir.

Their work is often published in venues such as Experimental Eye Research, UNC Libraries, Alzheimer's & Dementia, Journal of Biological Chemistry, and the Journal of Clinical Sleep Medicine.

Best Publications

  • Shotgun identification of protein modifications from protein complexes and lens tissue

    Michael J. MacCoss;W. Hayes McDonald;Anita Saraf;Rovshan Sadygov

  • Small heat-shock proteins and their potential role in human disease

    John I Clark;Paul J Muchowski

  • Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy.

    Todd R. Klesert;Diane H. Cho;John I. Clark;James Maylie

  • SPARC Deficiency Leads to Early-Onset Cataractogenesis

    K Norose;J I Clark;N A Syed;A Basu

  • Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues.

    Abbot F. Clark;H. Thomas Steely;Jaime E. Dickerson;Sherry English-Wright

  • ATP-enhanced molecular chaperone functions of the small heat shock protein human alphaB crystallin.

    Paul J. Muchowski;John I. Clark

  • The Cardiomyopathy and Lens Cataract Mutation in αB-crystallin Alters Its Protein Structure, Chaperone Activity, and Interaction with Intermediate Filaments in Vitro

    Ming Der Perng;Paul J. Muchowski;Paul van den IJssel;Gabrielle J.S. Wu

  • Fractal analysis of region-based vascular change in the normal and non-proliferative diabetic retina.

    Arpenik Avakian;Robert E. Kalina;E. Helene Sage;Avni H. Rambhia

  • A Novel Assay of Angiogenesis in the Quail Chorioallantoic Membrane: Stimulation by bFGF and Inhibition by Angiostatin According to Fractal Dimension and Grid Intersection

    Patricia Parsons-Wingerter;Biakhre Lwai;Mong Che Yang;Katherine E. Elliott

  • Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF

    Barbara Brewitt;John I. Clark

  • Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome

    Juliet A. Moncaster;Roberto Pineda;Robert D. Moir;Suqian Lu

  • The relationship of the glenohumeral joint capsule to the rotator cuff.

    John Clark;John A. Sidles;F. A. Matsen

  • Femoral neck length and hip fracture risk.

    John Michelotti;John Clark

  • Late complications of allogeneic and autologous marrow transplantation.

    K. M. Sullivan;M. Mori;J. Sanders;M. Siadak

  • Interactive domains for chaperone activity in the small heat shock protein, human αB crystallin

    Joy G. Ghosh;Marcus R. Estrada;John I. Clark

  • Interactions between Important Regulatory Proteins and Human αB Crystallin

    Joy G. Ghosh;Ananth K. Shenoy;John I. Clark

  • Fibroblast Growth Factor-2 Selectively Stimulates Angiogenesis of Small Vessels in Arterial Tree

    Patricia Parsons-Wingerter;Katherine E. Elliott;John I. Clark;Andrew G. Farr

  • Site-directed mutations within the core "alpha-crystallin" domain of the small heat-shock protein, human alphaB-crystallin, decrease molecular chaperone functions.

    Paul J Muchowski;Gabrielle J.S Wu;Jack J.N Liang;Elinor T Adman

  • Human αB-Crystallin SMALL HEAT SHOCK PROTEIN AND MOLECULAR CHAPERONE

    Paul J. Muchowski;James A. Bassuk;Nicolette H. Lubsen;John I. Clark

  • Theoretical and experimental basis for the inhibition of cataract.

    George B. Benedek;Jayanti Pande;George M. Thurston;George M. Thurston;John I. Clark

Frequent Co-Authors

Rudolph E. Tanzi
Rudolph E. Tanzi Harvard University
Paul J. Muchowski
Paul J. Muchowski University of California, San Francisco
Robert D. Moir
Robert D. Moir Harvard University
E. Helene Sage
E. Helene Sage Benaroya Research Institute
John R. Yates
John R. Yates Scripps Research Institute
Keith M. Sullivan
Keith M. Sullivan Duke University
Thomas Wisniewski
Thomas Wisniewski New York University
Charles W. Wilkinson
Charles W. Wilkinson University of Washington
Jean E. Sanders
Jean E. Sanders Fred Hutchinson Cancer Research Center

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