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D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
13461
World Ranking
15462
National Ranking
6455

Overview

Paul J. Muchowski is affiliated with the University of California, San Francisco in the United States. Their research spans several interconnected fields including pharmacology, molecular biology, cognitive neuroscience, and experimental and cognitive psychology.

The scientist's recent work focuses notably on cannabis and cannabinoid research, sleep and wakefulness research, and the study of sleep-related disorders. Additional areas of interest include ubiquitin and proteasome pathways, protein degradation and inhibitors, and glycosylation and glycoproteins research.

Paul J. Muchowski has contributed to a variety of publications, including the following recent papers:

  • Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study, 2024, Journal of Clinical Sleep Medicine
  • Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease, 2020, Nature Communications
  • A Cannabidiol/Terpene Formulation Increases Restorative Sleep in Insomniacs: A Double-Blind, Placebo-controlled, Randomized, Crossover Study, 2023, bioRxiv (Cold Spring Harbor Laboratory)
  • Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease, 2020, Nature Communications
  • Chaperone Functions of the E3 Ubiquitin Ligase CHIP, 2021, UNC Libraries

The scientist frequently publishes in key venues such as:

  • Nature Communications
  • Journal of Clinical Sleep Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • SLEEP

Collaborative work is a significant part of their research. Frequent co-authors include Michael Wang, Marcus Faust, Scott Abbott, Vikrant Patel, and Eric Y. Chang.

Paul J. Muchowski's research contributes across multiple domains related to neurological health, sleep disorders, and molecular pathways affecting protein degradation and cellular processes. Their publications reflect interdisciplinary engagements with both clinical and molecular aspects of biomedical science.

Best Publications

  • Kynurenines in the mammalian brain: when physiology meets pathology

    Robert Schwarcz;John P. Bruno;Paul J. Muchowski;Hui-Qiu Wu

  • Modulation of neurodegeneration by molecular chaperones.

    Paul J. Muchowski;Jennifer L. Wacker

  • Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

    Paul J. Muchowski;Gregor Schaffar;Annie Sittler;Erich E. Wanker

  • Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

    Daniel Zwilling;Shao-Yi Huang;Korrapati V. Sathyasaikumar;Francesca M. Notarangelo

  • Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

    Stephen Willingham;Tiago Fleming Outeiro;Michael J. DeVit;Susan L. Lindquist

  • Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models *

    Irene H. Cheng;Kimberly Scearce-Levie;Kimberly Scearce-Levie;Justin Legleiter;Justin Legleiter;Jorge J. Palop;Jorge J. Palop

  • Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

    Dagmar E. Ehrnhoefer;Martin Duennwald;Phoebe Markovic;Jennifer L. Wacker

  • A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

    Flaviano Giorgini;Paolo Guidetti;QuangVu Nguyen;Simone C Bennett

  • Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

    Paul J. Muchowski

  • Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer.

    Jennifer L Wacker;M Hadi Zareie;Hanson Fong;Mehmet Sarikaya

  • Flanking sequences profoundly alter polyglutamine toxicity in yeast

    Martin L. Duennwald;Smitha Jagadish;Paul J. Muchowski;Susan Lindquist

  • Small heat-shock proteins and their potential role in human disease

    John I Clark;Paul J Muchowski

  • The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

    Susanna Campesan;Edward W. Green;Carlo Breda;Korrapati V. Sathyasaikumar

  • Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.

    Justin Legleiter;Emily Mitchell;Gregor P. Lotz;Ellen Sapp

  • Identifying polyglutamine protein species in situ that best predict neurodegeneration

    Jason Miller;Montserrat Arrasate;Elizabeth Brooks;Clare Peters Libeu

  • Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

    Paul J. Muchowski;Ke Ning;Crislyn D'Souza-Schorey;Stanley Fields

  • ATP-enhanced molecular chaperone functions of the small heat shock protein human alphaB crystallin.

    Paul J. Muchowski;John I. Clark

  • The Cardiomyopathy and Lens Cataract Mutation in αB-crystallin Alters Its Protein Structure, Chaperone Activity, and Interaction with Intermediate Filaments in Vitro

    Ming Der Perng;Paul J. Muchowski;Paul van den IJssel;Gabrielle J.S. Wu

  • Functional interaction between the integrin antagonist neutrophil inhibitory factor and the I domain of CD11b/CD18.

    Paul J. Muchowski;Li Zhang;Eric R. Chang;Howard R. Soule

  • Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

    Kirupa Sathasivam;Amin Lane;Justin Legleiter;Alice Warley

Frequent Co-Authors

Robert Schwarcz
Robert Schwarcz University of Maryland, Baltimore
John I. Clark
John I. Clark University of Washington
Leslie M. Thompson
Leslie M. Thompson University of California, Irvine
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Tiago F. Outeiro
Tiago F. Outeiro University of Göttingen
Frédéric Saudou
Frédéric Saudou Grenoble Alpes University
Nephi Stella
Nephi Stella University of Washington
Sarah J. Tabrizi
Sarah J. Tabrizi University College London

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