World's Best Scientists 2026 revealed!

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Neuroscience

D-Index
118
Citations
66212
World Ranking
401
National Ranking
237

Medicine

D-Index
119
Citations
66486
World Ranking
3837
National Ranking
2101

Research.com Recognitions

  • 2013 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 2010 - Sedgwick Memorial Medal, American Public Health Association
  • 2010 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Lennart Mucke is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these areas, Mucke has focused extensively on Alzheimer's disease research and treatments, neuroscience and neuropharmacology research, as well as mechanisms of neuroinflammation and neurodegeneration.

The scientist's work frequently addresses topics such as epilepsy research and treatment, genetics and neurodevelopmental disorders, cholinesterase and neurodegenerative diseases, and single-cell and spatial transcriptomics.

Mucke's publication record includes articles in prominent scientific journals with frequent publications in:

  • Science Translational Medicine
  • Science
  • JAMA Neurology
  • Neuron
  • Cell Reports

Selected recent papers reflect a focus on tau protein involvement in neurological disorders, Alzheimer's disease, and neurodevelopmental conditions. Notable publications include:

  • "Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies," 2021, Science
  • "Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity," 2021, JAMA Neurology
  • "A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease," 2020, Science Translational Medicine
  • "Tau Reduction Prevents Key Features of Autism in Mouse Models," 2020, Neuron
  • "Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony," 2021, Cell Reports

Frequent collaborators in Mucke's research include Gui-Qiu Yu, Xinxing Yu, Che-Wei Chang, Qiang Shao, and Kaitlyn Ho, highlighting a network of researchers working together on related topics.

The work delves into subfields such as cellular and molecular neuroscience, molecular biology, physiology, neurology, and genetics.

Mucke's career has been recognized with several awards, including the Metlife Foundation Award for Medical Research in Alzheimer's Disease (2013), the Sedgwick Memorial Medal from the American Public Health Association (2010), and the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases from the American Academy of Neurology (2010). They are also a member of the Association of American Physicians.

Best Publications

  • Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

    Dora Games;David Adams;Ree Alessandrini;Robin Barbour

  • Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

    Eliezer Masliah;Edward Rockenstein;Isaac Veinbergs;Margaret Mallory

  • High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

    Lennart Mucke;Eliezer Masliah;Gui-Qiu Yu;Margaret Mallory

  • Alzheimer mechanisms and therapeutic strategies.

    Yadong Huang;Lennart Mucke

  • Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

    Erik D. Roberson;Kimberly Scearce-Levie;Jorge J. Palop;Fengrong Yan

  • Amyloid-[beta]-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

    Jorge J Palop;Lennart Mucke

  • Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

    Michael Eddleston;L Mucke

  • Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease

    Jorge J. Palop;Jeannie Chin;Erik D. Roberson;Jun Wang

  • Inflammation in Neurodegenerative Disease—A Double-Edged Sword

    Tony Wyss-Coray;Lennart Mucke

  • Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

    Albert Y. Hsia;Eliezer Masliah;Lisa Mcconlogue;Gui Qiu Yu

  • Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

    Toby G Bush;Narman Puvanachandra;Catherine H Horner;Anabella Polito

  • Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction

    Lennart Mucke;Dennis J. Selkoe

  • Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

    Laure Verret;Edward O. Mann;Giao B. Hang;Albert M.I. Barth

  • Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

    Iain L. Campbell;Carmela R. Abraham;Eliezer Masliah;Phillip Kemper

  • The many faces of tau.

    Meaghan Morris;Sumihiro Maeda;Keith Vossel;Lennart Mucke

  • Network abnormalities and interneuron dysfunction in Alzheimer disease

    Jorge J. Palop;Lennart Mucke

  • β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

    Eliezer Masliah;Edward Rockenstein;Isaac Veinbergs;Yutaka Sagara

  • SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

    Jennifer Chen;Yungui Zhou;Sarah Mueller-Steiner;Lin Feng Chen

  • Epilepsy and Cognitive Impairments in Alzheimer Disease

    Jorge J. Palop;Lennart Mucke

  • Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

    Stephanie M. Toggas;Eliezer Masliah;Edward M. Rockenstein;Glenn F. Rail

Frequent Co-Authors

Eliezer Masliah
Eliezer Masliah National Institutes of Health
Jorge J. Palop
Jorge J. Palop University of California, San Francisco
Tony Wyss-Coray
Tony Wyss-Coray Stanford University
Li Gan
Li Gan Cornell University
Jeannie Chin
Jeannie Chin Baylor College of Medicine
Robert W. Mahley
Robert W. Mahley University of California, San Francisco
Jacob Raber
Jacob Raber Oregon Health & Science University
Carmela R. Abraham
Carmela R. Abraham Boston University
Michael B. A. Oldstone
Michael B. A. Oldstone Scripps Research Institute
Margaret Mallory
Margaret Mallory University of California, San Diego

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