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D-Index & Metrics

Medicine

D-Index
76
Citations
24771
World Ranking
18685
National Ranking
9309

Overview

Yadong Huang is affiliated with the Gladstone Institutes in the United States and has contributed extensively to the fields of neuroscience and medicine. Their research focuses primarily on Alzheimer's disease, neuroinflammation, and mechanisms of neurodegeneration, as well as broader topics within neuroscience and neuropharmacology.

Their main fields of study include:

  • Neuroscience
  • Medicine

Within these areas, Huang has worked on several specialized subfields:

  • Physiology
  • Neurology
  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Cognitive Neuroscience

The main research topics covered by their publications are:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Nuclear Receptors and Signaling
  • Tryptophan and brain disorders
  • Single-cell and spatial transcriptomics
  • Neurogenesis and neuroplasticity mechanisms

Huang's recent notable papers include:

  • "APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia" (2024, Nature)
  • "Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms" (2021, Annual Review of Pathology Mechanisms of Disease)
  • "Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease" (2021, Nature Neuroscience)
  • "Cell type-specific roles of APOE4 in Alzheimer disease" (2024, Nature Reviews Neuroscience)
  • "Neurons require glucose uptake and glycolysis in vivo" (2023, Cell Reports)

Frequent co-authors collaborating with Huang include:

  • Seo Yeon Yoon
  • Nicole Koutsodendris
  • Yanxia Hao
  • Misha Zilberter
  • Maxine Nelson

Huang's work is regularly published in established scientific journals and platforms, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Alzheimer's & Dementia
  • Nature Aging
  • Nature Neuroscience

Best Publications

  • Alzheimer mechanisms and therapeutic strategies.

    Yadong Huang;Lennart Mucke

  • Apolipoprotein E4: A Causative Factor and Therapeutic Target in Neuropathology, Including Alzheimer's Disease

    Robert W. Mahley;Karl H. Weisgraber;Yadong Huang

  • High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport

    Gerd Assmann;Helmut Schulte;Arnold von Eckardstein;Yadong Huang

  • ApoE genotype accounts for the vast majority of AD risk and AD pathology.

    Jacob Raber;Yadong Huang;J.Wesson Ashford

  • Apolipoprotein E: Structure and Function in Lipid Metabolism, Neurobiology, and Alzheimer’s Diseases

    Yadong Huang;Robert W. Mahley

  • Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

    Karen L. Ring;Leslie M. Tong;Maureen E. Balestra;Robyn Javier

  • Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

    Robert W. Mahley;Karl H. Weisgraber;Yadong Huang

  • Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

    Daniel Zwilling;Shao-Yi Huang;Korrapati V. Sathyasaikumar;Francesca M. Notarangelo

  • Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

    Qin Xu;Aubrey Bernardo;David Walker;Tiffany Kanegawa

  • Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes

    Robert W. Mahley;Yadong Huang;Stanley C. Rall

  • Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond.

    Robert W. Mahley;Yadong Huang

  • Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

    Yadong Huang;Xiao Qin Liu;Tony Wyss-Coray;Walter J. Brecht

  • Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

    Walter J. Brecht;Faith M. Harris;Shengjun Chang;Ina Tesseur

  • Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

    Faith M. Harris;Walter J. Brecht;Qin Xu;Ina Tesseur

  • Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

    Chengzhong Wang;Ramsey Najm;Qin Xu;Dah-eun Jeong

  • Apolipoprotein e sets the stage: response to injury triggers neuropathology.

    Robert W. Mahley;Yadong Huang

  • Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

    Shengjun Chang;Tian ran Ma;R. Dennis Miranda;Maureen E. Balestra

  • Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

    Shiming Ye;Yadong Huang;Karin Müllendorff;Liming Dong

  • Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

    Yaisa Andrews-Zwilling;Nga Bien-Ly;Qin Xu;Gang Li

  • GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

    Gang Li;Nga Bien-Ly;Yaisa Andrews-Zwilling;Qin Xu

Frequent Co-Authors

Robert W. Mahley
Robert W. Mahley University of California, San Francisco
Gerd Assmann
Gerd Assmann University of Münster
Karl H. Weisgraber
Karl H. Weisgraber University of California, San Francisco
Bruce L. Miller
Bruce L. Miller University of California, San Francisco
Lennart Mucke
Lennart Mucke University of California, San Francisco
Tony Wyss-Coray
Tony Wyss-Coray Stanford University
Loren M. Frank
Loren M. Frank University of California, San Francisco
Eliezer Masliah
Eliezer Masliah National Institutes of Health
John L.R. Rubenstein
John L.R. Rubenstein University of California, San Francisco
Giovanni Coppola
Giovanni Coppola University of California, Los Angeles

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