Karl H. Weisgraber mainly focuses on Apolipoprotein E, Biochemistry, Apolipoprotein B, Lipoprotein and Endocrinology. His Apolipoprotein E study incorporates themes from LDL receptor, Very low-density lipoprotein, Receptor and Cholesterol. His Cholesterol research incorporates elements of Genetics and Disease.
His Biochemistry research is multidisciplinary, incorporating perspectives in Alzheimer's disease and Cell biology. His Apolipoprotein B research is multidisciplinary, incorporating elements of Membrane and Neurodegeneration. His work in Endocrinology tackles topics such as Internal medicine which are related to areas like In vivo, In vitro, Chemical modification and Proteolysis.
Karl H. Weisgraber mostly deals with Apolipoprotein E, Biochemistry, Apolipoprotein B, Lipoprotein and Internal medicine. He studies Apolipoproteins E, a branch of Apolipoprotein E. While the research belongs to areas of Biochemistry, he spends his time largely on the problem of Neurodegeneration, intersecting his research to questions surrounding Cell biology.
His Apolipoprotein B research incorporates themes from Genetics, Phospholipid and Lipoprotein lipase. His Lipoprotein research includes themes of Lipid metabolism and Genetically modified mouse. His research links Endocrinology with Internal medicine.
His primary scientific interests are in Apolipoprotein E, Biochemistry, Neurodegeneration, Cell biology and Apolipoprotein B. Apolipoprotein E is a subfield of Internal medicine that Karl H. Weisgraber explores. In the field of Biochemistry, his study on Lipoprotein and Very low-density lipoprotein overlaps with subjects such as In situ.
His biological study spans a wide range of topics, including Molecular biology, Protein species, Alzheimer's disease, Protein structure and Mitochondrion. Karl H. Weisgraber has researched Cell biology in several fields, including Trinucleotide repeat expansion, Neurite, Apolipoprotein e4, Astrocyte and Epitope. His research integrates issues of Guanidine, Stereochemistry and Small molecule in his study of Apolipoprotein B.
Karl H. Weisgraber mainly investigates Neurodegeneration, Apolipoprotein E, Biochemistry, Apolipoprotein B and Apolipoproteins E. His Neurodegeneration research incorporates elements of Mitochondrion, Function, Cell biology, Molecular biology and Alzheimer's disease. As part of one scientific family, Karl H. Weisgraber deals mainly with the area of Apolipoprotein E, narrowing it down to issues related to the Cholesterol, and often Immunology.
His Biochemistry study frequently involves adjacent topics like Rational design. His research investigates the connection with Apolipoproteins E and areas like Plasma protein binding which intersect with concerns in Genetics, Apolipophorin III, Receptor and Gene isoform. His work on Very low-density lipoprotein as part of general Lipoprotein study is frequently linked to Phosphotungstic acid, Electron tomography and Negative stain, therefore connecting diverse disciplines of science.
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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease
Warren J. Strittmatter;Karl H. Weisgraber;David Y. Huang;Li Ming Dong.
Proceedings of the National Academy of Sciences of the United States of America (1993)
Apolipoprotein E4: A Causative Factor and Therapeutic Target in Neuropathology, Including Alzheimer's Disease
Robert W. Mahley;Karl H. Weisgraber;Yadong Huang.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Apolipoprotein E: Structure-Function Relationships
Karl H. Weisgraber.
Advances in Protein Chemistry (1994)
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
B. P. Nathan;S. Bellosta;D. A. Sanan;K. H. Weisgraber.
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.
R E Pitas;J K Boyles;S H Lee;D Hui.
Journal of Biological Chemistry (1987)
Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.
K H Weisgraber;S C Rall;R W Mahley.
Journal of Biological Chemistry (1981)
Human apolipoprotein E. The complete amino acid sequence.
S C Rall;K H Weisgraber;R W Mahley.
Journal of Biological Chemistry (1982)
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Charles Wilson;Mark R. Wardell;Karl H. Weisgraber;Robert W. Mahley.
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Thomas L. Innerarity;Robert W. Mahley;Karl H. Weisgraber;Thomas P. Bersot.
Journal of Lipid Research (1990)
Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding
Thomas L. Innerarity;Karl H. Weisgraber;Kay S. Arnold;Robert W. Mahley.
Proceedings of the National Academy of Sciences of the United States of America (1987)
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