Leslie M. Thompson

Overview

Best Publications

• A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

  Marcy E. MacDonald;Christine M. Ambrose;Mabel P. Duyao;Richard H. Myers

  7760
  Citations

• A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

  M Shah;N Datson;L Srinidhi;VP Stanton

  4892
  Citations

• Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia.

  Rita Shiang;Leslie M. Thompson;Ya-Zhen Zhu;Deanna M. Church

  1568
  Citations

• Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

  Joan S. Steffan;Laszlo Bodai;Judit Pallos;Marnix Poelman

  1468
  Citations

• The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

  Joan S. Steffan;Aleksey Kazantsev;Olivera Spasic-Boskovic;Marilee Greenwald

  1252
  Citations

• Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

  E. Hockly;V.M. Richon;B. Woodman;D.L. Smith

  1051
  Citations

• Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

  Nancy S. Wexler;Judith Lorimer;Julie Porter;Fidela Gomez

  1037
  Citations

• SUMO modification of Huntingtin and Huntington's disease pathology

  Joan S. Steffan;Namita Agrawal;Judit Pallos;Erica Rockabrand

  871
  Citations

• Therapeutic application of histone deacetylase inhibitors for central nervous system disorders.

  Aleksey G. Kazantsev;Leslie M. Thompson

  849
  Citations

• Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

  Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  700
  Citations

• Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

  Patricia L. Tavormina;Rita Shiang;Leslie M. Thompson;Ya-Zhen Zhu

  695
  Citations

• Induced Pluripotent Stem Cells from Patients with Huntington’s Disease : Show CAG Repeat-Expansion-Associated Phenotypes

  Virginia B. Mattis;Soshana P. Svendsen;Allison Ebert;Clive N. Svendsen

  651
  Citations

• Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.

  Kim N. Green;Joan S. Steffan;Hilda Martinez-Coria;Xuemin Sun

  472
  Citations

• Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

  Dagmar E. Ehrnhoefer;Martin Duennwald;Phoebe Markovic;Jennifer L. Wacker

  467
  Citations

• The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

  Alexandra B. Keenan;Sherry L. Jenkins;Kathleen M. Jagodnik;Simon Koplev

  446
  Citations

• IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

  Leslie Michels Thompson;Charity T. Aiken;Linda S. Kaltenbach;Namita Agrawal

  446
  Citations

• SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

  Ruth Luthi-Carter;David M. Taylor;Judit Pallos;Emmanuel Lambert

  393
  Citations

• Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

  Xiaofeng Gu;Xiaofeng Gu;Erin R. Greiner;Erin R. Greiner;Rakesh Mishra;Ravindra Kodali

  362
  Citations

• Mutant Huntingtin Disrupts the Nuclear Pore Complex

  Jonathan C. Grima;J. Gavin Daigle;Nicolas Arbez;Kathleen C. Cunningham

  332
  Citations

• Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

  Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

  8
  Citations