J. Lawrence Marsh

Overview

Best Publications

• Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

  Joan S. Steffan;Laszlo Bodai;Judit Pallos;Marnix Poelman

  1468
  Citations

• Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

  E. Hockly;V.M. Richon;B. Woodman;D.L. Smith

  1051
  Citations

• SUMO modification of Huntingtin and Huntington's disease pathology

  Joan S. Steffan;Namita Agrawal;Judit Pallos;Erica Rockabrand

  871
  Citations

• Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer.

  Karine Hovanes;Tony W.H. Li;Jesus E. Munguia;Trung Truong

  615
  Citations

• Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

  Dagmar E. Ehrnhoefer;Martin Duennwald;Phoebe Markovic;Jennifer L. Wacker

  467
  Citations

• IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

  Leslie Michels Thompson;Charity T. Aiken;Linda S. Kaltenbach;Namita Agrawal

  446
  Citations

• SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

  Ruth Luthi-Carter;David M. Taylor;Judit Pallos;Emmanuel Lambert

  393
  Citations

• Twisted gastrulation is a conserved extracellular BMP antagonist

  Jeffrey J. Ross;Osamu Shimmi;Peter Vilmos;Anna Petryk

  363
  Citations

• The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis

  Erica Rockabrand;Natalia Slepko;Antonello Pantalone;Vidya N. Nukala

  341
  Citations

• A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

  Xiaoqian Zhang;Donna L. Smith;Anatoli B. Meriin;Sabine Engemann

  329
  Citations

• Potential function for the Huntingtin protein as a scaffold for selective autophagy.

  Joseph Ochaba;Tamás Lukacsovich;George Csikos;Shuqiu Zheng

  323
  Citations

• Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

  J. Lawrence Marsh;Heli Walker;Heidi Theisen;Ya-Zhen Zhu

  308
  Citations

• Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

  Judit Pallos;Laszlo Bodai;Tamas Lukacsovich;Judith M. Purcell

  303
  Citations

• The HSPGs Syndecan and Dallylike Bind the Receptor Phosphatase LAR and Exert Distinct Effects on Synaptic Development

  Karl G. Johnson;Alan P. Tenney;Aurnab Ghose;April M. Duckworth

  286
  Citations

• ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

  Pamela Maher;Richard Dargusch;Laszlo Bodai;Paul E. Gerard

  278
  Citations

• Drosophila in the Study of Neurodegenerative Disease

  J. Lawrence Marsh;Leslie Michels Thompson

  272
  Citations

• A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

  Barbara L. Apostol;Alexsey Kazantsev;Simona Raffioni;Katalin Illes

  219
  Citations

• Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila

  A. Grens;E. Mason;J.L. Marsh;H.R. Bode

  208
  Citations

• A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.

  Aleksey Kazantsev;Heli A. Walker;Natalia Slepko;James E. Bear

  204
  Citations

• Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila

  Namita Agrawal;Judit Pallos;Natalia Slepko;Barbara L. Apostol

  201
  Citations