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Neuroscience

D-Index
56
Citations
14791
World Ranking
4463
National Ranking
2022

Overview

Huaibin Cai is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on medicine and neuroscience, with significant contributions to biochemistry, genetics, and molecular biology. The scientist's work spans multiple subfields, including cellular and molecular neuroscience, neurology, molecular biology, physiology, and cell biology.

The main topics covered by Huaibin Cai's research include Parkinson's disease mechanisms and treatments, neuroscience and neuropharmacology research, neurological disorders and treatments, genetic neurodegenerative diseases, nuclear receptors and signaling, amyotrophic lateral sclerosis research, and cannabis and cannabinoid research.

Frequent coauthors in their research collaborations include Weidong Le, Lisa Chang, Lupeng Wang, Sarah Hawes, and Jinhui Ding.

Huaibin Cai has published extensively in various academic venues. The most frequent publication platforms are:

  • Ageing and Neurodegenerative Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Neurodegeneration
  • Frontiers in Neural Circuits
  • Nature Communications

Recent papers authored or coauthored by Huaibin Cai include:

  • Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease, 2021, Frontiers in Neural Circuits
  • Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice, 2022, PLoS ONE
  • Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction, 2022, Nature Communications
  • Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson's Disease, 2021, Frontiers in Neural Circuits
  • Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging, 2020, Molecular Neurodegeneration

Best Publications

  • BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.

    Huaibin Cai;Yanshu Wang;Diane McCarthy;Hongjin Wen

  • BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

    Fiona M. Laird;Huaibin Cai;Alena V. Savonenko;Mohamed H. Farah

  • Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients

    Rena Li;Kristina Lindholm;Li-Bang Yang;Xu Yue

  • Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

    Xian Lin;Loukia Parisiadou;Xing Long Gu;Lizhen Wang

  • Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Fang Guo;Xinyao Liu;Huaibin Cai;Weidong Le;Weidong Le

  • Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

    Xing Long Gu;Cai Xia Long;Lixin Sun;Chengsong Xie

  • Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

    Loukia Parisiadou;Chengsong Xie;Hyun Jin Cho;Xian Lin

  • Cloning and Characterization of Neuropilin-1-Interacting Protein: A PSD-95/Dlg/ZO-1 Domain-Containing Protein That Interacts with the Cytoplasmic Domain of Neuropilin-1

    Huaibin Cai;Randall R. Reed

  • Deletion at ITPR1 Underlies Ataxia in Mice and Spinocerebellar Ataxia 15 in Humans

    Joyce Van De Leemput;Jayanth Chandran;Jayanth Chandran;Melanie A. Knight;Lynne A. Holtzclaw

  • Genetically engineered mouse models of neurodegenerative diseases

    Philip C. Wong;Huaibin Cai;David R. Borchelt;Donald L. Price

  • MicroRNA-205 regulates the Expression of Parkinson’s disease-related Leucine-rich Repeat Kinase 2 Protein

    Hyun Jin Cho;Guoxiang Liu;Seok Min Jin;Loukia Parisiadou

  • Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

    Youren Tong;Emilie Giaime;Hiroo Yamaguchi;Takaharu Ichimura

  • RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

    Marcel P. Van Der Brug;Jeff Blackinton;Jeff Blackinton;Jayanth Chandran;Ling Yang Hao

  • Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

    Xian Lin;Loukia Parisiadou;Carmelo Sgobio;Guoxiang Liu

  • The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

    Nicolas Dzamko;Francisco Inesta-Vaquera;Jiazhen Zhang;Chengsong Xie

  • LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.

    Loukia Parisiadou;Jia Yu;Carmelo Sgobio;Chengsong Xie

  • The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

    Lizhen Wang;Chengsong Xie;Elisa Greggio;Loukia Parisiadou

  • Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis

    Chunxing Yang;Hongyan Wang;Tao Qiao;Bin Yang

  • Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

    Tong Li;Guojun Ma;Huaibin Cai;Donald L. Price

  • Loss of ALS2 Function Is Insufficient to Trigger Motor Neuron Degeneration in Knock-Out Mice But Predisposes Neurons to Oxidative Stress

    Huaibin Cai;Xian Lin;Chengsong Xie;Fiona M. Laird

  • Corrigendum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

    Loukia Parisiadou;Jia Yu;Carmelo Sgobio;Chengsong Xie

Frequent Co-Authors

Xiao-Xin Yan
Xiao-Xin Yan Central South University
Peter R. Patrylo
Peter R. Patrylo Southern Illinois University School of Medicine
David M. Lovinger
David M. Lovinger National Institutes of Health
Robert G. Struble
Robert G. Struble Southern Illinois University School of Medicine
Mark R. Cookson
Mark R. Cookson National Institutes of Health
Dena G. Hernandez
Dena G. Hernandez National Institutes of Health
Andrew B. Singleton
Andrew B. Singleton National Institutes of Health
Javier Simón-Sánchez
Javier Simón-Sánchez University of Tübingen
Henry Houlden
Henry Houlden University College London
Nicholas W. Wood
Nicholas W. Wood University College London

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