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D-Index & Metrics

Neuroscience

D-Index
42
Citations
5323
World Ranking
7727
National Ranking
120

Overview

Xiao-Xin Yan is affiliated with Central South University in China. Their research primarily focuses on medicine, biochemistry, genetics, molecular biology, and neuroscience. They have contributed extensively to the study of neurological disorders, neurodegeneration, and related fields.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Subfields of interest cover:

  • Molecular Biology
  • Neurology
  • Physiology
  • Cellular and Molecular Neuroscience
  • Genetics

Research topics addressed by Xiao-Xin Yan span multiple areas, including:

  • Alzheimer's disease research and treatments
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Parkinson's Disease Mechanisms and Treatments
  • Genetic Neurodegenerative Diseases
  • Neurological disorders and treatments

Frequent publication venues for their work consist of:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Aging Neuroscience
  • Alzheimer's & Dementia
  • Journal of Medicinal Chemistry
  • Nature Communications

Some of their recent published papers include:

  • TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration (2023, Immunity)
  • Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease (2022, Small)
  • β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice (2023, Nature Neuroscience)
  • PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis (2021, Protein & Cell)
  • Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle (2021, Stem Cell Research & Therapy)

Xiao-Xin Yan frequently collaborates with several researchers. Coauthors with whom they have multiple publications include:

  • Qi-Lei Zhang
  • Aihua Pan
  • Lily Wan
  • Ewen Tu
  • Mengchao Cui

Best Publications

  • Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model.

    Zsolt Toth;Xiao Xin Yan;Suzie Haftoglou;Charles E. Ribak

  • Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy.

    I Spigelman;X.-X Yan;A Obenaus;E.Y.-S Lee

  • β‐Secretase‐1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development

    Xue Mei Zhang;Yan Cai;Yan Cai;Kun Xiong;Huaibin Cai

  • TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.

    Unknown

  • Corticotropin-releasing hormone (CRH)-containing neurons in the immature rat hippocampal formation: light and electron microscopic features and colocalization with glutamate decarboxylase and parvalbumin.

    Xiao Xin Yan;Zsolt Toth;Linda Schultz;Charles E. Ribak

  • Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups

    Yan Cai;Kun Xiong;Yaping Chu;Duan-Wu Luo

  • Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain.

    Xiao-Xin Yan;Joseph Najbauer;Cynthia C. Woo;Khashayar Dashtipour

  • Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?

    Robert G. Struble;Tom Ala;Peter R. Patrylo;Gregory J. Brewer

  • NADPH-Diaphorase-Positive Neurons in Primate Cerebral Cortex Colocalize with GABA and Calcium-Binding Proteins

    X. X. Yan;L. S. Jen;L.J. Garey

  • Parasagittal patches in the granular layer of the developing and adult rat cerebellum as demonstrated by NADPH-diaphorase histochemistry.

    Xiao Xin Yan;Ling Sun Jen;Laurence J. Garey

  • Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: Partial colocalization with mature interneuron markers

    Kun Xiong;Duan-Wu Luo;Peter R. Patrylo;Xue-Gang Luo

  • Doublecortin-expressing cells persist in the associative cerebral cortex and amygdala in aged nonhuman primates

    Xue-Mei Zhang;Xue-Mei Zhang;Yan Cai;Yan Cai;Yaping Chu;Er-Yun Chen

  • CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation.

    J Liu;J Liu;C Gao;W Chen;W Ma

  • Spectrin Breakdown Products (SBDPs) as Potential Biomarkers for Neurodegenerative Diseases

    Xiao-Xin Yan;Andreas Jeromin

  • Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline

    Lauren Macklin;Chelsea M. Griffith;Yan Cai;Gregory M. Rose

  • Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and activity in vivo in the rat retina

    Kun Xiong;Huaibin Cai;Xue Gang Luo;Robert G. Struble

  • Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats

    Snjezana Lelas;Harvey Wong;Yu-Wen Li;Karen L. Heman

  • β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation.

    Yan Cai;Kun Xiong;Xue Mei Zhang;Xue Mei Zhang;Huaibin Cai

  • Development of NADPH-diaphorase activity in the rat neocortex.

    X.X. Yan;L.J. Garey;L.S. Jen

  • Immunoreactivity for GABA plasma membrane transporter, GAT-1, in the developing rat cerebral cortex: transient presence in the somata of neocortical and hippocampal neurons.

    Xiao-Xin Yan;Wayna A Cariaga;Charles E Ribak

  • Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats

    Xiaohua Deng;Meili Li;Weiming Ai;Lixin He

Frequent Co-Authors

Peter R. Patrylo
Peter R. Patrylo Southern Illinois University School of Medicine
Charles E. Ribak
Charles E. Ribak University of California, Irvine
Huaibin Cai
Huaibin Cai National Institutes of Health
Robert G. Struble
Robert G. Struble Southern Illinois University School of Medicine
Igor Spigelman
Igor Spigelman University of California, Los Angeles
J. Victor Nadler
J. Victor Nadler Duke University
Paul S. Buckmaster
Paul S. Buckmaster Stanford University
Yaping Chu
Yaping Chu Rush University Medical Center
Tallie Z. Baram
Tallie Z. Baram University of California, Irvine
Jeffrey H. Kordower
Jeffrey H. Kordower Arizona State University

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