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Neuroscience

D-Index
38
Citations
7092
World Ranking
8505
National Ranking
3625

Overview

Yuncai Chen is a researcher affiliated with the University of California, Irvine in the United States. Their work spans across multiple domains in neuroscience and engineering, with a particular focus on understanding the biological and behavioral mechanisms underlying stress responses and neuroendocrine regulation.

The main fields of study for Chen include Neuroscience, with notable subfields such as Behavioral Neuroscience, Electrical and Electronic Engineering, Social Psychology, Cellular and Molecular Neuroscience, and Biological Psychiatry. Their research topics prominently feature Stress Responses and Cortisol, Neuroendocrine regulation and behavior, Tryptophan and brain disorders, Neuroscience and Neuropharmacology Research, Advancements in Battery Materials, Advanced Battery Materials and Technologies, and Memory and Neural Mechanisms.

Chen's recent publications highlight a range of studies combining neurobiology and materials science. Selected recent papers include:

  • "Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice," 2023, Nature Communications
  • "Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity," 2020, Cell Reports
  • "Understanding the lithium dendrites growth in garnet-based solid-state lithium metal batteries," 2021, Journal of Power Sources
  • "Single-Cell Transcriptional Changes in Hypothalamic Corticotropin-Releasing Factor-Expressing Neurons After Early-Life Adversity Inform Enduring Alterations in Vulnerabilities to Stress," 2021, Biological Psychiatry Global Open Science
  • "Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits," 2020, Journal of Neuroscience

Chen's collaborative efforts include frequent co-authors such as Tallie Z. Baram, Matthew T. Birnie, Annabel K. Short, Aidan L. Pham, and Jessica L. Bolton. This collaboration reflects interdisciplinary approaches that integrate molecular neuroscience with behavioral studies and engineering principles.

The primary publication venues for Chen's research comprise bioRxiv (Cold Spring Harbor Laboratory), Journal of Power Sources, Biological Psychiatry Global Open Science, Journal of Neuroscience, and Hippocampus. These venues indicate a balance of preprint dissemination and peer-reviewed journals across different scientific communities.

Best Publications

  • Mechanisms of Late-Onset Cognitive Decline after Early-Life Stress

    Kristen L. Brunson;Enikö Kramár;Bin Lin;Yuncai Chen

  • Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks.

    Yuncai Chen;Tallie Z Baram

  • Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors

    Autumn S. Ivy;Christopher S. Rex;Yuncai Chen;Céline Dubé

  • Developmental Febrile Seizures Modulate Hippocampal Gene Expression of Hyperpolarization-Activated Channels in an Isoform- and Cell-Specific Manner

    Amy Brewster;Roland A. Bender;Yuncai Chen;Celine Dube

  • Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone

    Yuncai Chen;Céline M. Dubé;Courtney J. Rice;Tallie Z. Baram

  • Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling

    Yuncai Chen;Christopher S. Rex;Courtney J. Rice;Céline M. Dubé

  • Immunocytochemical Distribution of Corticotropin-Releasing Hormone Receptor Type-1 (CRF1)-Like Immunoreactivity in the Mouse Brain: Light Microscopy Analysis Using an Antibody Directed Against the C-Terminus

    Yuncai Chen;Kristen L. Brunson;Marianne B. Müller;Wayna Cariaga

  • Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress

    Kristen L. Brunson;Mariam Eghbal-Ahmadi;Roland Bender;Yuncai Chen

  • The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.

    Annie Vogel-Ciernia;Dina P. Matheos;Ruth M. Barrett;Enikoe A. Kramar

  • Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress.

    Y Chen;K.L Brunson;G Adelmann;R.A Bender

  • Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene.

    Jessica L. Bolton;Jenny Molet;Limor Regev;Yuncai Chen

  • Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.

    Yuncai Chen;Roland A. Bender;Kristen L. Brunson;Jörn K. Pomper

  • Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis.

    Yuncai Chen;Roland A. Bender;Michael Frotscher;Tallie Z. Baram

  • Tuning synaptic transmission in the hippocampus by stress: the CRH system

    Yuncai Chen;Adrienne L. Andres;Michael Frotscher;Tallie Z. Baram

  • Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

    Xiao-Dong Wang;Yuncai Chen;Miriam Wolf;Klaus V. Wagner

  • Neuroplasticity of the hypothalamic-pituitary-adrenal axis early in life requires recurrent recruitment of stress-regulating brain regions.

    Kristina A. Fenoglio;Yuncai Chen;Tallie Z. Baram

  • Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress

    P M Maras;J Molet;Y Chen;C Rice

  • Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling.

    Y Chen;E A Kramár;L Y Chen;A H Babayan

  • Quantitative Analysis and Subcellular Distribution of mRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus

    Amy L. Brewster;Yuncai Chen;Roland A. Bender;Amy Yeh

  • Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks.

    Gary P. Brennan;Deblina Dey;Yuncai Chen;Katelin P. Patterson

  • Stress and the developing hippocampus: a double-edged sword?

    Kristen L. Brunson;Yuncai Chen;Sarit Avishai-Eliner;Sarit Avishai-Eliner;Tallie Z. Baram

Frequent Co-Authors

Tallie Z. Baram
Tallie Z. Baram University of California, Irvine
Christine M. Gall
Christine M. Gall University of California, Irvine
Roland A. Bender
Roland A. Bender Universität Hamburg
Céline Dubé
Céline Dubé University of California, Irvine
Enikö A. Kramár
Enikö A. Kramár University of California, Irvine
Michael Frotscher
Michael Frotscher Universität Hamburg
Frances M. Leslie
Frances M. Leslie University of California, Irvine
Kerry J. Ressler
Kerry J. Ressler Harvard University
Julie C. Lauterborn
Julie C. Lauterborn University of California, Irvine
Marianne B. Müller
Marianne B. Müller Johannes Gutenberg University of Mainz

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