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D-Index
35
Citations
6822
World Ranking
9133
National Ranking
3852

Overview

Céline Dubé is a researcher affiliated with the University of California, Irvine in the United States, specializing in the fields of medicine and neuroscience. The primary focus of their research lies in cellular and molecular neuroscience, with additional investigations in psychiatry and mental health, molecular biology, pharmacology, and organic chemistry.

The scientist's work broadly covers several key topics within neuroscience and neuropharmacology, including epilepsy research and treatment, ion channel regulation and function, pharmacogenetics and drug metabolism, pharmacology and obesity treatment, chemical synthesis and alkaloids, as well as pharmacological effects and toxicity studies.

Dubé's recent scholarly output includes research on the role of specific voltage-gated sodium channels in seizure control, antiseizure medication efficacy, and pharmacokinetic/pharmacodynamic relationships of antiseizure drugs using rodent models. Recent published papers include:

  • The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control (2024, British Journal of Pharmacology)
  • Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is l-Norfenfluramine a Better Follow-Up Compound to Racemic-Fenfluramine? (2024, International Journal of Molecular Sciences)
  • NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice (2023, bioRxiv [Cold Spring Harbor Laboratory])
  • The Pharmacokinetic and Pharmacodynamic Relationship of Clinically Used Antiseizure Medications in the Maximal Electroshock Seizure Model in Rodents (2025, International Journal of Molecular Sciences)
  • Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is l-Norfenfluramine a Better Follow-Up Compound to Racemic-Fenfluramine? (2023, Preprints.org)

Dubé collaborates frequently with several coauthors, including J. P. Johnson, Girish Bankar, Karen Nelkenbrecher, Robin Sherrington, and Andrea Lindgren. Collaboration with these scientists has contributed to multiple publications across various venues.

The most common venues for Dubé's publications include the International Journal of Molecular Sciences, bioRxiv (Cold Spring Harbor Laboratory), Preprints.org, the British Journal of Pharmacology, and Neurotherapeutics. These journals indicate a focus on molecular mechanisms, pharmacology, neurotherapeutics, and rapid communication of preliminary research findings in neuroscience.

Best Publications

  • Interleukin-1β Contributes to the Generation of Experimental Febrile Seizures

    Celine Dubé;Annamaria Vezzani;Marga Behrens;Tamas Bartfai

  • Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors

    Autumn S. Ivy;Christopher S. Rex;Yuncai Chen;Céline Dubé

  • Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term.

    Celine Dube;Kang Chen;Mariam Eghbal-Ahmadi;Kristen Brunson

  • Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis.

    Céline Dubé;Cristina Richichi;Roland A. Bender;Grace Chung

  • Developmental Febrile Seizures Modulate Hippocampal Gene Expression of Hyperpolarization-Activated Channels in an Isoform- and Cell-Specific Manner

    Amy Brewster;Roland A. Bender;Yuncai Chen;Celine Dube

  • Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone

    Yuncai Chen;Céline M. Dubé;Courtney J. Rice;Tallie Z. Baram

  • Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling

    Yuncai Chen;Christopher S. Rex;Courtney J. Rice;Céline M. Dubé

  • Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers.

    Céline M. Dubé;Teresa Ravizza;Mark Hamamura;Qinqin Zha

  • Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death

    Patrick G. Sullivan;Celine Dubé;Kristina Dorenbos;Oswald Steward

  • Fever, febrile seizures and epilepsy

    Céline M. Dubé;Amy L. Brewster;Cristina Richichi;Qinqin Zha

  • Altered Function of the SCN1A Voltage-gated Sodium Channel Leads to γ-Aminobutyric Acid-ergic (GABAergic) Interneuron Abnormalities

    Melinda S. Martin;Karoni Dutt;Ligia Assumpção Papale;Ligia Assumpção Papale;Celine M. Dube

  • Febrile seizures: Mechanisms and relationship to epilepsy

    Céline M. Dubé;Amy L. Brewster;Tallie Z. Baram

  • Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures

    Roland A. Bender;Celine Dubé;Rebeca Gonzalez-Vega;Erene W. Mina

  • Neuron‐restrictive silencer factor‐mediated hyperpolarization‐activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

    Shawn McClelland;Corey Flynn;Corey Flynn;Celine Dubé;Cristina Richichi

  • Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.

    Céline Dubé;Sylvette Boyet;Christian Marescaux;Astrid Nehlig

  • The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes.

    Shawn McClelland;Gary P Brennan;Celine Dubé;Seeta Rajpara

  • Cognitive dysfunction after experimental febrile seizures.

    Céline M. Dubé;Jun-Li Zhou;Mark Hamamura;Qian Zhao

  • Correlation between Hypermetabolism and Neuronal Damage during Status Epilepticus Induced by Lithium and Pilocarpine in Immature and Adult Rats

    Maria José da Silva Fernandes;Céline Dubé;Sylvette Boyet;Christian Marescaux

  • Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model

    Véronique André;Céline Dubé;Jennifer François;Claire Leroy

  • A novel, noninvasive, predictive epilepsy biomarker with clinical potential.

    ManKin Choy;Celine M. Dubé;Katelin Patterson;X Samuel R. Barnes

  • Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death.

    Céline Dubé;Hon Yu;Orhan Nalcioglu;Tallie Z. Baram

Frequent Co-Authors

Tallie Z. Baram
Tallie Z. Baram University of California, Irvine
Astrid Nehlig
Astrid Nehlig Inserm : Institut national de la santé et de la recherche médicale
Roland A. Bender
Roland A. Bender Universität Hamburg
Yuncai Chen
Yuncai Chen University of California, Irvine
Christophe Bernard
Christophe Bernard Aix-Marseille University
Christian Marescaux
Christian Marescaux Grenoble Alpes University
Gregory L. Holmes
Gregory L. Holmes University of Vermont
Véronique M. André
Véronique M. André UCB Pharma (Belgium)
Annamaria Vezzani
Annamaria Vezzani Mario Negri Institute for Pharmacological Research
Miriam H. Meisler
Miriam H. Meisler University of Michigan–Ann Arbor

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