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Terence J. O'Brien

Terence J. O'Brien

D-Index & Metrics

Medicine

D-Index
100
Citations
38410
World Ranking
8255
National Ranking
241

Overview

Terence J. O'Brien is affiliated with Monash University in Australia and has contributed extensively to the field of medicine, focusing particularly on epilepsy research and treatment. Their work spans a range of interconnected subfields, including psychiatry and mental health, neurology, pediatrics, perinatology, child health, cognitive neuroscience, and cellular and molecular neuroscience.

The principal topics in O'Brien's research include epilepsy research and treatment, pharmacological effects and toxicity studies, traumatic brain injury and neurovascular disturbances, neuroscience and neuropharmacology research, EEG and brain-computer interfaces, traumatic brain injury research, and pregnancy and medication impact.

O'Brien has published numerous papers in several key journals, with notable contributions including:

  • Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex, 2020, JAMA Neurology
  • Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience, 2020, Journal of NeuroInterventional Surgery
  • White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study, 2020, Brain
  • Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study, 2020, Science Advances
  • Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease, 2022, JAMA Neurology

The bulk of O'Brien's publications have appeared in prominent venues such as Epilepsia, Epilepsy & Behavior, bioRxiv (Cold Spring Harbor Laboratory), Epilepsia Open, and Neurology. These platforms reflect a strong orientation towards both clinical and translational research in epilepsy and associated neurological disorders.

Frequent collaborators in their research include Patrick Kwan, Piero Perucca, Lucy Vivash, Charles B. Malpas, and Mastura Monif. These coauthors reflect a broad network encompassing experts in epilepsy and neurological sciences.

Best Publications

  • Epilepsy in adults

    Roland D Thijs;Rainer Surges;Terence J O'Brien;Josemir W Sander

  • De novo mutations in epileptic encephalopathies

    Andrew S. Allen;Samuel F. Berkovic;Patrick Cossette;Norman Delanty

  • Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study.

    Mark J Cook;Mark J Cook;Terence J O'Brien;Terence J O'Brien;Samuel F Berkovic;Michael Murphy;Michael Murphy

  • Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study.

    Christopher D Whelan;Christopher D Whelan;Andre Altmann;Juan A Botía;Neda Jahanshad

  • Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

    Bassel Abou-Khalil;Pauls Auce;Andreja Avbersek;Melanie Bahlo

  • Seizure control and treatment in pregnancy: Observations from the EURAP epilepsy pregnancy registry

    Torbjörn Tomson;D. Battino;E. Bonizzoni;J. Craig

  • MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome.

    R. P. Carne;T. J. O'Brien;T. J. O'Brien;C. J. Kilpatrick;C. J. Kilpatrick;L. R. MacGregor;L. R. MacGregor

  • Mutations in DEPDC5 cause familial focal epilepsy with variable foci

    Leanne M Dibbens;Boukje de Vries;Simona Donatello;Sarah E Heron

  • Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy A randomized trial

    Jacqueline A. French;Gregory L. Krauss;Robert T. Wechsler;Xue Feng Wang

  • Interictal spikes and epileptic seizures: their relationship and underlying rhythmicity.

    Philippa J. Karoly;Dean R. Freestone;Ray Boston;David B. Grayden

  • Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

    Thomas J Oxley;Nicholas L Opie;Sam E John;Gil S Rind;Gil S Rind

  • Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System.

    Isabell Kiral-Kornek;Subhrajit Roy;Ewan Nurse;Ewan Nurse;Benjamin Mashford

  • Inflammation in epileptogenesis after traumatic brain injury.

    Kyria M. Webster;Mujun Sun;Peter Crack;Terence J. O’Brien

  • Localization of the epileptic focus by low-resolution electromagnetic tomography in patients with a lesion demonstrated by MRI.

    Gregory A. Worrell;Terrence D. Lagerlund;Frank W. Sharbrough;Benjamin H. Brinkmann

  • De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies

    Candace T. Myers;Jacinta M. McMahon;Amy L. Schneider;Slavé Petrovski;Slavé Petrovski

  • Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

    Richard Anney;A. Avbersek;D. Balding;L. Baum

  • NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant γ Oscillations Independent of Hyperlocomotion and the State of Consciousness

    Tahir Mohammed Hadi Brohi Hakami;Nigel Jones;Elena Tolmacheva;Julien Gaudias

  • Factors predictive of the outcome of frontal lobe epilepsy surgery

    R. K. Mosewich;Elson L. So;T. J. O'Brien;G. D. Cascino

  • Identification of new epilepsy treatments: Issues in preclinical methodology

    Aristea S. Galanopoulou;Paul S. Buckmaster;Kevin J. Staley;Solomon L. Moshé

  • Erratum: De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies (American Journal of Human Genetics (2014) 95(4) (360–370)(S0002929714003838)(10.1016/j.ajhg.2014.08.013))

    Silke Appenzeller;Rudi Balling;Nina Barisic;Stéphanie Baulac

Frequent Co-Authors

Patrick Kwan
Patrick Kwan Monash University
Nigel C. Jones
Nigel C. Jones Monash University
Sandy R. Shultz
Sandy R. Shultz Monash University
Mark J. Cook
Mark J. Cook University of Melbourne
Dennis Velakoulis
Dennis Velakoulis University of Melbourne
Samuel F. Berkovic
Samuel F. Berkovic University of Melbourne
Piero Perucca
Piero Perucca University of Melbourne
John D. Wark
John D. Wark University of Melbourne
Patricia Desmond
Patricia Desmond University of Melbourne
Slavé Petrovski
Slavé Petrovski AstraZeneca (United Kingdom)

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