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Molecular Biology

D-Index
51
Citations
12363
World Ranking
2486
National Ranking
1228

Overview

Pierre D. McCrea is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research focuses on several interconnected areas within biochemistry, genetics, molecular biology, and medicine, with a particular emphasis on molecular biology and cellular and molecular neuroscience.

Their contributions span key topics such as:

  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Hippo pathway signaling and YAP/TAZ
  • Axon Guidance and Neuronal Signaling
  • Epigenetics and DNA Methylation
  • RNA Research and Splicing
  • Neuroscience and Neuropharmacology Research

McCrea's recent publications illustrate these themes and include:

  • "Novel phospho-switch function of delta-catenin in dendrite development" (2020) in The Journal of Cell Biology
  • "A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals" (2021) in Biochemical and Biophysical Research Communications
  • "Delta-Catenin as a Modulator of Rho GTPases in Neurons" (2022) in Frontiers in Cellular Neuroscience
  • "p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development in vitro" (2023) in Frontiers in Cellular Neuroscience
  • "Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier" (2023) in eLife

The frequent coauthors working with McCrea include:

  • Yogesh Srivastava
  • Adriana Paulucci-Holthauzen
  • M. Neal Waxham
  • Maxsam Donta
  • Lydia L. Mireles

Their work is frequently published in venues such as:

  • Frontiers in Cellular Neuroscience
  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • The Journal of Cell Biology
  • Biochemical and Biophysical Research Communications

These research outputs contribute to fields of study including cellular biology, physiology, and molecular mechanisms underlying cancer and neuronal development. McCrea's focus on catenin family proteins and their signaling pathways reflects an interest in how these molecular players regulate cellular structure and communication, particularly within the nervous system and cancer biology.

Best Publications

  • Interactions between Sox9 and β-catenin control chondrocyte differentiation

    Haruhiko Akiyama;Jon P. Lyons;Yuko Mori-Akiyama;Xiaohong Yang

  • A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.

    Pierre D. Mccrea;Christoph W. Turck;Barry Gumbiner

  • Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

    Janet Heasman;Aaron Crawford;Kim Goldstone;Peggy Garner-Hamrick

  • Telomerase modulates Wnt signalling by association with target gene chromatin

    Jae Il Park;Andrew S. Venteicher;Ji Yeon Hong;Jinkuk Choi

  • Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

    Noriko Funayama;François Fagotto;Pierre McCrea;Barry M. Gumbiner

  • Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.

    Albert B. Reynolds;Juliet Daniel;Pierre D. Mccrea;Margaret J. Wheelock

  • The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.

    Mark Peifer;Pierre D. McCrea;Kathleen J. Green;Eric Wieschaus

  • Catenins as mediators of the cytoplasmic functions of cadherins

    Barry M. Gumbiner;Pierre D. McCrea

  • Kaiso/p120-Catenin and TCF/β-Catenin Complexes Coordinately Regulate Canonical Wnt Gene Targets

    Jae Il Park;Jae Il Park;Si Wan Kim;Jon P. Lyons;Jon P. Lyons;Hong Ji

  • Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure.

    P D McCrea;B M Gumbiner

  • Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.

    Pierre D. McCrea;William M. Brieher;Barry M. Gumbiner

  • beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex.

    Ying S. Tao;Robert A. Edwards;Benjamin Tubb;Susan Wang

  • Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.

    Si Wan Kim;Jae Il Park;Christopher M. Spring;Amy K. Sater

  • Wnt-4 activates the canonical β-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/β-catenin activity in kidney epithelial cells

    Jon P. Lyons;Ulrich W. Mueller;Hong Ji;Christopher Everett

  • PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation

    Hae Yun Jung;Sohee Jun;Moonsup Lee;Han Cheon Kim

  • Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix.

    Chi Zhang;Kyucheol Cho;Yehong Huang;Jon P. Lyons

  • Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor

    Dan Liu;Iman El-Hariry;Anastasios J. Karayiannakis;Jonathan Wilding

  • Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer.

    A. Grothey;R. Hashizume;Aysegul A Sahin;Pierre D McCrea

  • Lung epithelial branching program antagonizes alveolar differentiation

    Daniel R. Chang;Denise Martinez Alanis;Rachel K. Miller;Hong Ji

  • A role for Kaiso-p120ctn complexes in cancer?

    Frans M. van Roy;Pierre D. McCrea

Frequent Co-Authors

Malgorzata Kloc
Malgorzata Kloc Houston Methodist
Barry M. Gumbiner
Barry M. Gumbiner Seattle Children's Hospital
Junjie Chen
Junjie Chen The University of Texas MD Anderson Cancer Center
Michelle Craig Barton
Michelle Craig Barton The University of Texas MD Anderson Cancer Center
Albert B. Reynolds
Albert B. Reynolds Vanderbilt University
Frans van Roy
Frans van Roy Ghent University
Axel Grothey
Axel Grothey University of Tennessee at Knoxville
Steven E. Artandi
Steven E. Artandi Stanford University
Sergei Y. Sokol
Sergei Y. Sokol Icahn School of Medicine at Mount Sinai
Lei Li
Lei Li The University of Texas MD Anderson Cancer Center

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