World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
39739
World Ranking
3073
National Ranking
1555

Overview

Barry M. Gumbiner is affiliated with Seattle Children's Hospital in the United States. Their academic work spans several fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Radiology, Nuclear Medicine and Imaging, Cell Biology, Biomedical Engineering, and Oncology as key subfields of study.

The primary topics of research include Monoclonal and Polyclonal Antibodies Research, Wnt/β-catenin signaling in development and cancer, Nanofabrication and Lithography Techniques, Cellular Mechanics and Interactions, Cell Adhesion Molecules Research, HER2/EGFR in Cancer Research, and RNA Research and Splicing.

Frequent publication venues for their work are diverse, with multiple papers published in Zenodo (CERN European Organization for Nuclear Research), bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Tissue Barriers, and PNAS Nexus.

Among their recent papers are:

  • The functional activity of E-cadherin controls tumor cell metastasis at multiple steps, 2020, Proceedings of the National Academy of Sciences
  • E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease, 2021, Tissue Barriers
  • Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody, 2022, Proceedings of the National Academy of Sciences
  • Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography, 2022, PNAS Nexus
  • p120-catenin phosphorylation status alters E-cadherin mediated cell adhesion and ability of tumor cells to metastasize, 2020, PLoS ONE

Collaboration is a significant aspect of their research activity. Frequent coauthors include Leslayann Schecterson, Bin Xie, Sanjeevi Sivasankar, Shipeng Xu, and Allison Maker.

Best Publications

  • Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

    Barry M Gumbiner

  • Regulation of cadherin-mediated adhesion in morphogenesis

    Barry M Gumbiner

  • The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

    B Gumbiner;B Stevenson;A Grimaldi

  • The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

    Li Zeng;François Fagotto;Tong Zhang;Wei Hsu

  • Regulation of Cadherin Adhesive Activity

    Barry M. Gumbiner

  • Molecular and functional analysis of cadherin-based adherens junctions

    Alpha S. Yap;William M. Brieher;Barry M. Gumbiner

  • E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

    Nam-Gyun Kim;Eunjin Koh;Xiao Chen;Barry M. Gumbiner

  • A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.

    Pierre D. Mccrea;Christoph W. Turck;Barry Gumbiner

  • C-cadherin ectodomain structure and implications for cell adhesion mechanisms

    Titus J. Boggon;John Murray;Sophie Chappuis-Flament;Ellen Wong

  • Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

    Janet Heasman;Aaron Crawford;Kim Goldstone;Peggy Garner-Hamrick

  • A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

    Vivian Wong;Barry M. Gumbiner

  • Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1

    Barry Gumbiner;Theodore Lowenkopf;Dale Apatira

  • The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

    Alpha S. Yap;Carien M. Niessen;Barry M. Gumbiner

  • A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

    Barry Gumbiner;Kai Simons

  • Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

    Noriko Funayama;François Fagotto;Pierre McCrea;Barry M. Gumbiner

  • E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

    Cara J. Gottardi;Ellen Wong;Barry M. Gumbiner

  • Structure, biochemistry, and assembly of epithelial tight junctions

    B. Gumbiner

  • A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.

    Marc Lecuit;Shaynoor Dramsi;Cara Gottardi;Mary Fedor-Chaiken

  • Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

    François Fagotto;Ursula Glück;Barry M. Gumbiner

  • Signal transduction of beta-catenin.

    Barry M Gumbiner

Frequent Co-Authors

Pierre D. McCrea
Pierre D. McCrea The University of Texas MD Anderson Cancer Center
Alpha S. Yap
Alpha S. Yap University of Queensland
Cara J. Gottardi
Cara J. Gottardi Northwestern University
Deborah E. Leckband
Deborah E. Leckband University of Illinois at Urbana-Champaign
Regis B. Kelly
Regis B. Kelly University of California, San Francisco
Kai Simons
Kai Simons Lipotype
Christoph W. Turck
Christoph W. Turck Max Planck Society
Chris Kintner
Chris Kintner Salk Institute for Biological Studies
Giovanni Levi
Giovanni Levi French National Museum of Natural History
Ravinder N. M. Sehgal
Ravinder N. M. Sehgal San Francisco State University

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