World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
14124
World Ranking
15434
National Ranking
6440

Overview

Cara J. Gottardi is affiliated with Northwestern University in the United States. Their research spans multiple aspects of medicine and biochemistry, genetics, and molecular biology, with a particular focus on pulmonary and respiratory medicine.

Their recent scientific contributions include papers published between 2020 and 2023, covering topics related to lung biology, immune response, and cellular stress mechanisms. Notable publications include:

  • "Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia" (2021) in Nature
  • "The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging" (2021) in Journal of Clinical Investigation
  • "Mitochondrial integrated stress response controls lung epithelial cell fate" (2023) in Nature
  • "Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis" (2021) in Proceedings of the National Academy of Sciences
  • "Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis" (2020) in American Journal of Physiology-Lung Cellular and Molecular Physiology

The scientist collaborates frequently with several co-authors, whose partnerships are evidenced by a significant number of joint publications. These co-authors include:

  • G. R. Scott Budinger
  • Annette S. Flozak
  • Alexander V. Misharin
  • Hiam Abdala-Valencia
  • Nikolay S. Markov

Cara J. Gottardi has published predominantly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of Oncology
  • Nature
  • Journal of Clinical Investigation
  • American Journal of Respiratory Cell and Molecular Biology

Their main fields of study consist of:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these, their subfields of specialization include:

  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases
  • Immunology

The scientist's main research topics involve:

  • Cellular Mechanics and Interactions
  • Neonatal Respiratory Health Research
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Medical Imaging and Pathology Studies
  • Congenital Diaphragmatic Hernia Studies
  • Wnt/β-catenin signaling in development and cancer
  • COVID-19 Clinical Research Studies

Best Publications

  • Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

    Paul Andrew Reyfman;James McCauley Walter;Nikita Joshi;Kishore R. Anekalla

  • Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

    A Jeanes;C J Gottardi;A S Yap

  • Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

    Alexander V. Misharin;Luisa Morales-Nebreda;Paul A. Reyfman;Carla M. Cuda

  • Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.

    Rogan A Grant;Luisa Morales-Nebreda;Nikolay S Markov;Suchitra Swaminathan

  • E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

    Cara J. Gottardi;Ellen Wong;Barry M. Gumbiner

  • A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.

    Marc Lecuit;Shaynoor Dramsi;Cara Gottardi;Mary Fedor-Chaiken

  • The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

    Cara J. Gottardi;Monique Arpin;Alan S. Fanning;Daniel Louvard

  • Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

    Cara J. Gottardi;Barry M. Gumbiner

  • Molecular components of the adherens junction.

    Carien M. Niessen;Cara J. Gottardi

  • Phospho-regulation of β-Catenin Adhesion and Signaling Functions

    Rebecca Leadem Daugherty;Cara J. Gottardi

  • Adhesion signaling: How β-catenin interacts with its partners

    Cara J Gottardi;Barry M Gumbiner

  • Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.

    Robert B. Hamanaka;Andrea Glasauer;Paul Hoover;Shuangni Yang

  • Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.

    Jun Wei;Feng Fang;Anna P. Lam;Jennifer L. Sargent

  • A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages.

    Nikita Joshi;Satoshi Watanabe;Satoshi Watanabe;Rohan Verma;Renea P. Jablonski;Renea P. Jablonski

  • Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?

    Jun Wei;Denisa Melichian;Kazuhiro Komura;Monique Hinchcliff

  • A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells.

    Kevin C. Miranda;Tatiana Khromykh;Perpetina Christy;Tam Luan Le

  • Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

    Mark Lal;Xuewen Song;Jennifer L. Pluznick;Valeria Di Giovanni

  • Regulation of Wnt/β-Catenin Signaling by Protein Kinases

    Esther M. Verheyen;Cara J. Gottardi

  • Biotinylation and assessment of membrane polarity: caveats and methodological concerns

    Cara J. Gottardi;Lisa A. Dunbar;Michael J. Caplan

  • Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

    Masanori Ono;Ping Yin;Antonia Navarro;Molly B. Moravek

Frequent Co-Authors

G. R. Scott Budinger
G. R. Scott Budinger Northwestern University
Michael J. Caplan
Michael J. Caplan Yale University
Jacob I. Sznajder
Jacob I. Sznajder Northwestern University
Harris Perlman
Harris Perlman Northwestern University
Karen M. Ridge
Karen M. Ridge Northwestern University
John Varga
John Varga University of Michigan–Ann Arbor
Deborah E. Leckband
Deborah E. Leckband University of Illinois at Urbana-Champaign
Barry M. Gumbiner
Barry M. Gumbiner Seattle Children's Hospital
Alpha S. Yap
Alpha S. Yap University of Queensland
Ali Shilatifard
Ali Shilatifard Northwestern University

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