World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
23001
World Ranking
10539
National Ranking
4575

Overview

Harris Perlman is affiliated with Northwestern University in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on subfields including Immunology, Molecular Biology, Pathology and Forensic Medicine, Rheumatology, and Pulmonary and Respiratory Medicine.

The scientist's recent publications include the following papers:

  • Notch signalling drives synovial fibroblast identity and arthritis pathology, 2020, Nature
  • Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes, 2023, Nature
  • The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging, 2021, Journal of Clinical Investigation
  • Aging is associated with a systemic length-associated transcriptome imbalance, 2022, Nature Aging
  • Granzyme K activates the entire complement cascade, 2025, Nature

Perlman's research covers a range of topics, with a notable focus on systemic autoimmune diseases and immune system roles, including:

  • Systemic Sclerosis and Related Diseases
  • Systemic Lupus Erythematosus Research
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Single-cell and spatial transcriptomics
  • Rheumatoid Arthritis Research and Therapies

The frequent publication venues for their work demonstrate engagement with both high-impact journals and preprint platforms:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Communications
  • Journal of Clinical Investigation
  • Scientific Reports

Collaboration is a significant element of Perlman's research practice. Frequent coauthors include:

  • Jennifer H. Anolik
  • Carla M. Cuda
  • Andrew Filer
  • Deepak A. Rao
  • Laura T. Donlin

Best Publications

  • Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

    Simon Yona;Ki Wook Kim;Yochai Wolf;Alexander Mildner

  • Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

    Fan Zhang;Kevin Wei;Kamil Slowikowski;Chamith Y Fonseka

  • Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

    Laura A. Sena;Sha Li;Amit Jairaman;Murali Prakriya

  • Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

    Paul Andrew Reyfman;James McCauley Walter;Nikita Joshi;Kishore R. Anekalla

  • Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

    Alexander V. Misharin;Luisa Morales-Nebreda;Paul A. Reyfman;Carla M. Cuda

  • Distinct fibroblast subsets drive inflammation and damage in arthritis.

    Adam P. Croft;Joana Campos;Kathrin Jansen;Jason D. Turner

  • Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

    Alexander V. Misharin;Luisa Morales-Nebreda;Gökhan M. Mutlu;G. R. Scott Budinger

  • Exosomes From Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity

    Susmita Sahoo;Ekaterina Klychko;Tina Thorne;Sol Misener

  • Cell cycle exit upon myogenic differentiation

    Kenneth Walsh;Harris Perlman

  • Evidence for the Rapid Onset of Apoptosis in Medial Smooth Muscle Cells After Balloon Injury

    Harris Perlman;Luc Maillard;Kevin Krasinski;Kenneth Walsh

  • A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment.

    Shawn Rose;Alexander Misharin;Harris Perlman

  • FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis.

    Harris Perlman;Lisa J. Pagliari;Lisa J. Pagliari;Constantinos Georganas;Constantinos Georganas;Toshiaki Mano

  • Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

    Alexander V. Misharin;Carla M. Cuda;Rana Saber;Jason D. Turner

  • Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation.

    Hongtao Liu;Harris Perlman;Lisa J. Pagliari;Richard M. Pope

  • Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-Jun.

    Constantinos Georganas;Hongtao Liu;Harris Perlman;Alexander Hoffmann

  • Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity

    Jack Hutcheson;Jack Hutcheson;John C. Scatizzi;John C. Scatizzi;Akbar M. Siddiqui;G. Kenneth Haines

  • An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis.

    Harris Perlman;Harris Perlman;Xuejun Zhang;Min Wei Chen;Kenneth Walsh

  • p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene.

    Roy C. Smith;Didier Branellec;David H. Gorski;Kun Guo

  • A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages.

    Nikita Joshi;Satoshi Watanabe;Satoshi Watanabe;Rohan Verma;Renea P. Jablonski;Renea P. Jablonski

  • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis [Immunity 38 (2013) 79-91]

    Simon Yona;Ki Wook Kim;Yochai Wolf;Alexander Mildner

Frequent Co-Authors

G. R. Scott Budinger
G. R. Scott Budinger Northwestern University
Kenneth Walsh
Kenneth Walsh University of Virginia
Richard M. Pope
Richard M. Pope Northwestern University
Karen M. Ridge
Karen M. Ridge Northwestern University
Navdeep S. Chandel
Navdeep S. Chandel Northwestern University
Jacob I. Sznajder
Jacob I. Sznajder Northwestern University
Christopher D. Buckley
Christopher D. Buckley University of Oxford
Andrew Filer
Andrew Filer University of Birmingham
Cara J. Gottardi
Cara J. Gottardi Northwestern University
William E. Balch
William E. Balch Scripps Health

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