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Biology and Biochemistry

D-Index
104
Citations
37218
World Ranking
1261
National Ranking
744

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Denis Wirtz is affiliated with Johns Hopkins University in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a significant focus on oncology and cell biology.

Their publication record includes a number of recent papers in high-impact journals, reflecting the breadth of their scientific contributions. Notable papers include:

  • 3D genomic mapping reveals multifocality of human pancreatic precancers, 2024, Nature
  • Extracellular vesicles in immunomodulation and tumor progression, 2021, Nature Immunology
  • Single-cell morphology encodes metastatic potential, 2020, Science Advances
  • CODA: quantitative 3D reconstruction of large tissues at cellular resolution, 2022, Nature Methods
  • A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei, 2021, Nature Protocols

Wirtz's research fields of study cover a range within the life sciences, including:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their subfields of study are more specifically focused on:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Cancer Research
  • Biophysics

Their main topics of work demonstrate a strong emphasis on cancer research and cellular analysis techniques. These topics include:

  • Pancreatic and Hepatic Oncology Research
  • Single-cell and spatial transcriptomics
  • Cellular Mechanics and Interactions
  • Cancer Genomics and Diagnostics
  • Cell Image Analysis Techniques
  • Cancer Cells and Metastasis
  • AI in cancer detection

Frequent co-authors in their collaborative research include:

  • Ashley Kiemen
  • Pei-Hsun Wu
  • Laura D. Wood
  • André Forjaz

Wirtz has published extensively in various scientific venues, with the highest number of publications appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Science Advances
  • Nature Methods
  • Cell Systems

The scientist has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • The physics of cancer: the role of physical interactions and mechanical forces in metastasis

    Denis Wirtz;Konstantinos Konstantopoulos;Peter C. Searson

  • Hypoxia and the extracellular matrix: drivers of tumour metastasis

    Daniele M. Gilkes;Gregg L. Semenza;Denis Wirtz

  • Reversible Hydrogels from Self-Assembling Artificial Proteins

    Wendy A. Petka;James L. Harden;Kevin P. McGrath;Denis Wirtz

  • Micro- and macrorheology of mucus.

    Samuel K. Lai;Ying Ying Wang;Denis Wirtz;Justin Hanes

  • Particle Tracking Microrheology of Complex Fluids

    T. G. Mason;K. Ganesan;J. H. van Zanten;D. Wirtz

  • Particle-Tracking Microrheology of Living Cells: Principles and Applications

    Denis Wirtz

  • A distinctive role for focal adhesion proteins in three-dimensional cell motility

    Stephanie I. Fraley;Yunfeng Feng;Yunfeng Feng;Ranjini Krishnamurthy;Dong Hwee Kim

  • Mechanics of Living Cells Measured by Laser Tracking Microrheology

    Soichiro Yamada;Denis Wirtz;Scot C. Kuo

  • A perinuclear actin cap regulates nuclear shape

    Shyam B. Khatau;Christopher M. Hale;P. J. Stewart-Hutchinson;Meet S. Patel

  • A comparison of methods to assess cell mechanical properties.

    Pei Hsun Wu;Dikla Raz Ben Aroush;Atef Asnacios;Wei Chiang Chen

  • Water Permeation Drives Tumor Cell Migration in Confined Microenvironments

    Kimberly M. Stroka;Hongyuan Jiang;Shih Hsun Chen;Ziqiu Tong

  • Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts

    Daniele M. Gilkes;Saumendra Bajpai;Pallavi Chaturvedi;Denis Wirtz

  • Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

    Carmen Chak Lui Wong;Daniele M. Gilkes;Huafeng Zhang;Huafeng Zhang;Jasper Chen

  • Efficient active transport of gene nanocarriers to the cell nucleus

    Junghae Suh;Denis Wirtz;Justin Hanes

  • Micromechanical Mapping of Live Cells by Multiple-Particle-Tracking Microrheology

    Yiider Tseng;Thomas P. Kole;Denis Wirtz

  • Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

    Amit Agarwal;Pei Hsun Wu;Ethan G. Hughes;Masahiro Fukaya

  • Focal adhesion size uniquely predicts cell migration

    Dong Hwee Kim;Denis Wirtz

  • Enhanced Viscoelasticity of Human Cystic Fibrotic Sputum Correlates with Increasing Microheterogeneity in Particle Transport

    Michelle Dawson;Denis Wirtz;Justin Hanes

  • Extracellular vesicles in immunomodulation and tumor progression.

    Carolyn Marar;Carolyn Marar;Bartholomew Starich;Denis Wirtz

  • Three-dimensional cell migration does not follow a random walk

    Pei Hsun Wu;Anjil Giri;Sean X. Sun;Denis Wirtz;Denis Wirtz

Frequent Co-Authors

Daniele M. Gilkes
Daniele M. Gilkes Johns Hopkins University
Konstantinos Konstantopoulos
Konstantinos Konstantopoulos Johns Hopkins University
Gregory D. Longmore
Gregory D. Longmore Washington University in St. Louis
Peter C. Searson
Peter C. Searson Johns Hopkins University
Justin Hanes
Justin Hanes Johns Hopkins University
Gregg L. Semenza
Gregg L. Semenza Johns Hopkins University School of Medicine
Tian Li Wang
Tian Li Wang Johns Hopkins University
Benjamin W. Schafer
Benjamin W. Schafer Johns Hopkins University
Ie Ming Shih
Ie Ming Shih Johns Hopkins University
Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine

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