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Molecular Biology

D-Index
46
Citations
10763
World Ranking
2792
National Ranking
1339

Overview

Daniele M. Gilkes is affiliated with Johns Hopkins University in the United States. Their research predominantly focuses on the intersection of cancer biology, hypoxia, and molecular mechanisms underlying metastasis and cellular responses in tumor microenvironments.

Their recent publications demonstrate a consistent engagement with topics related to cancer progression and cellular behavior under hypoxic conditions. Notable papers include:

  • Extracellular fluid viscosity enhances cell migration and cancer dissemination, 2022, Nature
  • Single-cell morphology encodes metastatic potential, 2020, Science Advances
  • Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances, 2022, Cells
  • Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis, 2021, Proceedings of the National Academy of Sciences
  • Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner, 2020, Cancer Research

Frequent collaborators in their research include:

  • Inês Godet
  • Denis Wirtz
  • Gregg L. Semenza
  • Elana J. Fertig
  • Harsh H. Oza

Gilkes's work has been published extensively in journals such as:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Methods in Molecular Biology
  • Cell Systems
  • Cancers

The scientist's scholarly output spans several fields, primarily:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their research concentrates on specific subfields including:

  • Molecular Biology
  • Cancer Research
  • Oncology
  • Biomedical Engineering
  • Immunology

The main topics addressed in their work are:

  • Cancer, Hypoxia, and Metabolism
  • Cancer Cells and Metastasis
  • Single-cell and spatial transcriptomics
  • RNA modifications and cancer
  • Nanoplatforms for cancer theranostics
  • Epigenetics and DNA Methylation
  • Immune cells in cancer

In addition to journal articles, Gilkes has contributed to academic literature through a book publication:

  • Hypoxia, published by Springer Science+Business Media in 2024

This body of work reflects consistent involvement in exploring molecular aspects and cellular dynamics of cancer biology, with an emphasis on the role of hypoxia in tumor progression and therapeutic response mechanisms.

Best Publications

  • Hypoxia and the extracellular matrix: drivers of tumour metastasis

    Daniele M. Gilkes;Gregg L. Semenza;Denis Wirtz

  • Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts

    Daniele M. Gilkes;Saumendra Bajpai;Pallavi Chaturvedi;Denis Wirtz

  • Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

    Debangshu Samanta;Daniele M. Gilkes;Pallavi Chaturvedi;Lisha Xiang

  • Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

    Ting Wang;Daniele M. Gilkes;Naoharu Takano;Lisha Xiang

  • Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

    Carmen Chak Lui Wong;Daniele M. Gilkes;Huafeng Zhang;Huafeng Zhang;Jasper Chen

  • HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

    H Zhang;H Zhang;C C L Wong;H Wei;D M Gilkes

  • HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

    Huimin Zhang;Huimin Zhang;Haiquan Lu;Lisha Xiang;John W. Bullen

  • ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

    Lihong Chen;Daniele M Gilkes;Yu Pan;William S Lane

  • Collagen Prolyl Hydroxylases are Essential for Breast Cancer Metastasis

    Daniele M. Gilkes;Pallavi Chaturvedi;Saumendra Bajpai;Carmen Chak-Lui Wong

  • Role of hypoxia-inducible factors in breast cancer metastasis

    Daniele M Gilkes;Gregg L Semenza

  • Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

    Daniele Gilkes;Saumendra Bajpai;Carmen Chak-Lui Wong;Pallavi Chaturvedi

  • Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

    Pallavi Chaturvedi;Daniele M. Gilkes;Carmen Chak Lui Wong;Carmen Chak Lui Wong;Kshitiz

  • MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin

    Baoli Hu;Daniele M. Gilkes;Bilal Farooqi;Said M. Sebti

  • Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis.

    Carmen Chak Lui Wong;Carmen Chak Lui Wong;Huafeng Zhang;Huafeng Zhang;Daniele M. Gilkes;Jasper Chen

  • Efficient p53 Activation and Apoptosis by Simultaneous Disruption of Binding to MDM2 and MDMX

    Baoli Hu;Daniele M. Gilkes;Jiandong Chen

  • BRCA1 and BRCA2 mutations and treatment strategies for breast cancer.

    Inês Godet;Daniele M. Gilkes;Daniele M. Gilkes

  • PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

    Debangshu Samanta;Youngrok Park;Shaida A. Andrabi;Laura M. Shelton

  • Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling

    Yulia Nefedova;Pingyan Cheng;Daniele Gilkes;Michelle Blaskovich

  • Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

    Daniele M. Gilkes;Lisha Xiang;Sun Joo Lee;Pallavi Chaturvedi

  • Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

    Pallavi Chaturvedi;Daniele M. Gilkes;Naoharu Takano;Gregg L. Semenza

Frequent Co-Authors

Gregg L. Semenza
Gregg L. Semenza Johns Hopkins University School of Medicine
Denis Wirtz
Denis Wirtz Johns Hopkins University
Huafeng Zhang
Huafeng Zhang University of Science and Technology of China
Saraswati Sukumar
Saraswati Sukumar Johns Hopkins University School of Medicine
Andre Levchenko
Andre Levchenko Yale University
Said M. Sebti
Said M. Sebti Virginia Commonwealth University
Rong Fan
Rong Fan Yale University
Amer A. Beg
Amer A. Beg University of South Florida
Chi V. Dang
Chi V. Dang University of Pennsylvania
Irene Oi-Lin Ng
Irene Oi-Lin Ng University of Hong Kong

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