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Biology and Biochemistry

D-Index
58
Citations
26440
World Ranking
12887
National Ranking
5484

Overview

Amer A. Beg is affiliated with the University of South Florida in the United States. Their research spans several key areas within biochemistry, genetics, molecular biology, and medicine, with a significant focus on oncology and related subfields such as molecular biology, immunology, genetics, and pulmonary and respiratory medicine.

Their work covers a range of topics including:

  • Virus-based gene therapy research
  • Cancer Immunotherapy and Biomarkers
  • Cancer Research and Treatments
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Cancer Genomics and Diagnostics
  • Radiomics and Machine Learning in Medical Imaging

Amer A. Beg has published extensively in notable venues. The most frequent publication outlets include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Journal of Clinical Oncology
  • The Journal of Immunology

Selected recent papers illustrating the scope and focus of their work are:

  • "ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis," 2022, published in Nature
  • "Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer," 2022, Clinical Cancer Research
  • "Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity," 2024, Cancer Cell
  • "TIMEx: tumor-immune microenvironment deconvolution web-portal for bulk transcriptomics using pan-cancer scRNA-seq signatures," 2021, Bioinformatics
  • "Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity," 2023, Cancer Immunology Research

Collaboration is a notable aspect of Amer A. Beg's scholarly activities. Frequent co-authors include:

  • Scott Antonia
  • Jhanelle E. Gray
  • Mark Robertson-Tessi
  • Robert A. Gatenby
  • Alexander R.A. Anderson

Best Publications

  • An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

    Amer A. Beg;David Baltimore

  • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B.

    Amer A. Beg;William C. Sha;Roderick T. Bronson;Sankar Ghosh

  • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

    A A Beg;T S Finco;P V Nantermet;A S Baldwin

  • The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

    Amer A. Beg;Albert S. Baldwin

  • I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

    A. A. Beg;S. M. Ruben;R. I. Scheinman;S. Haskill

  • Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

    Stephen Haskill;Amer A. Beg;S.Mark Tompkins;John S. Morris

  • Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon

    Xiuyan Wang;Ming Li;Hongyong Zheng;Thomas Muster

  • Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

    Amer A Beg

  • Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

    A A Beg;W C Sha;R T Bronson;D Baltimore

  • A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA

    Markus Bitzer;Gero von Gersdorff;Dan Liang;Alfredo Dominguez-Rosales

  • An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells.

    Ming Li;David F. Carpio;Ye Zheng;Peter Bruzzo

  • Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

    Fateh Ouaaz;Joseph Arron;Ye Zheng;Yongwon Choi

  • Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

    Swarnali Acharyya;S. Armando Villalta;Nadine Bakkar;Tepmanas Bupha-Intr

  • Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

    Timothy S. Finco;John K. Westwick;Jacqueline L. Norris;Amer A. Beg

  • Mechanism of All-Trans Retinoic Acid Effect on Tumor-Associated Myeloid-Derived Suppressor Cells

    Yulia Nefedova;Mayer Fishman;Simon Sherman;Xingyu Wang

  • NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

    Claudio Mauro;Shi Chi Leow;Elena Anso;Sonia Rocha

  • Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

    Timothy S. Finco;Amer A. Beg;Amer A. Beg;Albert S. Baldwin

  • Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

    Elizabeth Alcamo;Joseph P. Mizgerd;Bruce H. Horwitz;Rod Bronson

  • Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor κB Response

    Sirnona Saccani;Ivan Marazzi;Amer A. Beg;Gioacchino Natoli

  • HDAC inhibitors enhance T cell chemokine expression and augment response to PD-1 immunotherapy in lung adenocarcinoma

    Hong Zheng;Weipeng Zhao;Cihui Yan;Crystina C. Watson

Frequent Co-Authors

Eric B. Haura
Eric B. Haura University of South Florida
Albert S. Baldwin
Albert S. Baldwin University of North Carolina at Chapel Hill
Xue-Zhong Yu
Xue-Zhong Yu Medical College of Wisconsin
Scott J. Antonia
Scott J. Antonia Duke University
David Baltimore
David Baltimore California Institute of Technology
Ming O. Li
Ming O. Li Memorial Sloan Kettering Cancer Center
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Adolfo García-Sastre
Adolfo García-Sastre Icahn School of Medicine at Mount Sinai
John M. Koomen
John M. Koomen University of South Florida
Roderick T. Bronson
Roderick T. Bronson Harvard University

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