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Immunology

D-Index
138
Citations
87128
World Ranking
171
National Ranking
114

Research.com Recognitions

  • 2021 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Genetics/Molecular Biology and Cell Biology
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Patrick A. Baeuerle is affiliated with Cullinan Oncology, Inc. in the United States. The research is primarily focused on medicine, with significant contributions in immunology and microbiology. Subfields of study include oncology, immunology, radiology, nuclear medicine and imaging, electrical and electronic engineering, and biotechnology.

The scientist has contributed extensively to topics related to cancer and immune system research. Main research areas cover:

  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Cancer Research and Treatments
  • Cancer Immunotherapy and Biomarkers
  • Silicon Carbide Semiconductor Technologies

Recent notable papers authored or coauthored include:

  • "T-cell-engaging antibodies for the treatment of solid tumors: challenges and opportunities" (2022) - Current Opinion in Oncology
  • "Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?" (2020) - Cancer and Metastasis Reviews
  • "TriTACs, a Novel Class of T-Cell-Engaging Protein Constructs Designed for the Treatment of Solid Tumors" (2020) - Molecular Cancer Therapeutics
  • "Preclinical Characterization of HPN536, a Trispecific, T-Cell-Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors" (2020) - Clinical Cancer Research
  • "A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL" (2022) - Journal for ImmunoTherapy of Cancer

Frequent coauthors of Patrick A. Baeuerle include:

  • Jennifer S. Michaelson
  • Naveen K. Mehta
  • Kristan Meetze
  • Kavya Rakhra
  • Bochong Li

Contributions have been published in venues such as:

  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Journal for ImmunoTherapy of Cancer
  • Molecular Cancer Therapeutics
  • Cancer and Metastasis Reviews

Patrick A. Baeuerle has been recognized with awards including:

  • German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften (2021) in Genetics/Molecular Biology and Cell Biology
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Function and activation of NF-kappa B in the immune system.

    Patrick A. Baeuerle;Thomas Henkel

  • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

    R Schreck;P Rieber;P A Baeuerle

  • NF-κB: Ten Years After

    Patrick A Baeuerle;David Baltimore

  • I kappa B: a specific inhibitor of the NF-kappa B transcription factor.

    Patrick A. Baeuerle;David Baltimore

  • Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

    R Schreck;B Meier;D N Männel;W Dröge

  • Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

    Ralf Schreck;Kaj Albermann;Patrick A. Baeuerle

  • H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

    M. Meyer;R. Schreck;P.A. Baeuerle

  • Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B.

    Thomas Henkel;Thomas Machleidt;Irit Alkalay;Martin Krönke

  • Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

    Patrick A. Baeuerle;David Baltimore

  • The inducible transcription activator NF-κB: regulation by distinct protein subunits

    Patrick A. Baeuerle

  • Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody

    Ralf Bargou;Eugen Leo;Gerhard Zugmaier;Matthias Klinger

  • Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival

    Max S. Topp;Peter Kufer;Nicola Gökbuget;Mariele Goebeler

  • Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

    E. B.-M. Traenckner;H. L. Pahl;T. Henkel;K. N. Schmidt

  • Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

    K Brand;S Page;G Rogler;A Bartsch

  • Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

    Martine Collart;P Baeuerle;Pierre Vassalli

  • The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

    M.L. Schmitz;P.A. Baeuerle

  • The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

    Mark Kieran;Volker Blank;Frédérique Logeat;Joël Vandekerckhove

  • Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

    Barbara Kaltschmidt;Martin Uherek;Benedikt Volk;Patrick A. Baeuerle

  • Bispecific T-cell engaging antibodies for cancer therapy.

    Patrick A. Baeuerle;Carsten Reinhardt

  • Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

    Gerhard Rogler;Korbinian Brand;Daniela Vogl;Sharon Page

Frequent Co-Authors

Peter Kufer
Peter Kufer Amgen (United States)
Andreas Wolf
Andreas Wolf Max Planck Society
Christian Kaltschmidt
Christian Kaltschmidt Bielefeld University
Gert Riethmüller
Gert Riethmüller Ludwig-Maximilians-Universität München
David Baltimore
David Baltimore California Institute of Technology
Klaus Schulze-Osthoff
Klaus Schulze-Osthoff University of Tübingen
Heike L. Pahl
Heike L. Pahl University of Freiburg
Wieland B. Huttner
Wieland B. Huttner Max Planck Society
M. Lienhard Schmitz
M. Lienhard Schmitz University of Giessen
Andreas Mackensen
Andreas Mackensen University of Erlangen-Nuremberg

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