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Molecular Biology

D-Index
81
Citations
22710
World Ranking
967
National Ranking
78

Overview

Claus Scheidereit is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, oncology, immunology, and cancer research. Their published work also touches on topics related to electrical and electronic engineering.

The central topics of Scheidereit's research include:

  • NF-κB Signaling Pathways
  • PARP inhibition in cancer therapy
  • Immune Response and Inflammation
  • DNA Repair Mechanisms
  • Integrated Circuits and Semiconductor Failure Analysis
  • Toxin Mechanisms and Immunotoxins
  • Cancer Cells and Metastasis

Their recent publications illustrate a focus on molecular mechanisms linked to inflammation, immune response, and cancer biology. Some of the notable papers include:

  • "Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy," 2021, Journal of Cachexia Sarcopenia and Muscle
  • "Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors," 2020, JCI Insight
  • "Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65/RelA activation in senescence," 2021, The EMBO Journal
  • "TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation," 2022, The EMBO Journal
  • "Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut," 2020, The Journal of Pathology

Frequent publication venues for Scheidereit's work include bioRxiv (Cold Spring Harbor Laboratory), The EMBO Journal, Nature Communications, Zenodo (CERN European Organization for Nuclear Research), and the Journal of Cachexia Sarcopenia and Muscle.

Collaboration is an integral part of Scheidereit's research ecosystem. Frequent coauthors include Marina Kolesnichenko, Michael Willenbrock, Ahmet Buğra Tufan, Jens Peter von Kries, and Jana Wolf, indicating an interdisciplinary team approach within molecular medicine and cancer research.

Best Publications

  • NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition.

    Michael Hinz;Daniel Krappmann;Alexandra Eichten;Andreas Heder

  • Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

    R C Bargou;F Emmerich;D Krappmann;K Bommert

  • IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.

    Claus Scheidereit

  • The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus.

    Claus Scheidereit;Sabine Geisse;Hannes M. Westphal;Miguel Beato

  • Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.

    Susan A. Slaugenhaupt;Anat Blumenfeld;Sandra P. Gill;Maire Leyne

  • The IκB kinase complex in NF-κB regulation and beyond

    Michael Hinz;Claus Scheidereit

  • NF-kappaB and the innate immune response.

    Eunice N Hatada;Daniel Krappmann;Claus Scheidereit

  • Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

    M Naumann;C Scheidereit

  • Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-κB

    Stephan Mathas;Stephan Mathas;Michael Hinz;Ioannis Anagnostopoulos;Daniel Krappmann

  • Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro.

    Claus Scheidereit;Adriana Heguy;Robert G. Roeder

  • High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells

    Ralf C. Bargou;Corinna Leng;Daniel Krappmann;Florian Emmerich

  • A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.

    Claus Scheidereit;Claus Scheidereit;James A. Cromlish;Thomas Gerster;Kiyoshi Kawakami

  • Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters.

    Dietmar Von Der Ahe;Susanne Janich;Claus Scheidereit;Rainer Renkawitz

  • The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation.

    F G Wulczyn;D Krappmann;C Scheidereit

  • The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.

    R Dechend;F Hirano;K Lehmann;V Heissmeyer

  • Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity

    Michael Hinz;Petra Lemke;Ioannis Anagnostopoulos;Christine Hacker

  • Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro.

    Kiyoshi Kawakami;Claus Scheidereit;Robert G. Roeder

  • Reciprocal requirements for Eda/Edar/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction

    Yuhang Zhang;Philip Tomann;Thomas Andl;Natalie M. Gallant

  • Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

    Daniel Krappmann;Florian Emmerich;Florian Emmerich;Uwe Kordes;Erika Scharschmidt

  • The IjB kinase complex in NF-jB regulation and beyond

    Michael Hinz;Claus Scheidereit

Frequent Co-Authors

Daniel Krappmann
Daniel Krappmann Ludwig-Maximilians-Universität München
Bernd Dörken
Bernd Dörken Charité - University Medicine Berlin
Miguel Beato
Miguel Beato Centre for Genomic Regulation
Michael Hummel
Michael Hummel Charité - University Medicine Berlin
Bernd Dörken
Bernd Dörken Charité - University Medicine Berlin
Friedrich C. Luft
Friedrich C. Luft Charité - University Medicine Berlin
Michael Naumann
Michael Naumann Otto-von-Guericke University Magdeburg
Ioannis Anagnostopoulos
Ioannis Anagnostopoulos Charité - University Medicine Berlin
Rainer Dietz
Rainer Dietz Charité - University Medicine Berlin
Robert G. Roeder
Robert G. Roeder Rockefeller University

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