M. Lienhard Schmitz

Overview

Best Publications

• p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

  Wim Vanden Berghe;Stéphane Plaisance;Elke Boone;Karolien De Bosscher

  833
  Citations

• Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

  Thomas G. Hofmann;Andreas Möller;Hüseyin Sirma;Hanswalter Zentgraf

  749
  Citations

• The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex

  Steffen P. Hehner;Thomas G. Hofmann;Wulf Dröge;M. Lienhard Schmitz

  572
  Citations

• Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.

  Holger Buss;Anneke Dörrie;M. Lienhard Schmitz;Elke Hoffmann

  521
  Citations

• SESQUITERPENE LACTONES SPECIFICALLY INHIBIT ACTIVATION OF NF-λB BY PREVENTING THE DEGRADATION OF IλB-α AND IλB-$g(b)

  Michael Heinrich;M. Lienhard Schmitz

  483
  Citations

• Glucocorticoid-mediated repression of nuclear factor-κBdependent transcription involves direct interference with transactivation

  Karolien De Bosscher;M. Lienhard Schmitz;Wim Vanden Berghe;Stéphane Plaisance

  461
  Citations

• Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB

  Peter M Bork;M.Lienhard Schmitz;Michaela Kuhnt;Claudia Escher

  430
  Citations

• Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

  Andreas Dumont;Steffen P. Hehner;Thomas G. Hofmann;Marius Ueffing

  409
  Citations

• IκB-independent control of NF-κB activity by modulatory phosphorylations

  M.Lienhard Schmitz;Susanne Bacher;Michael Kracht

  351
  Citations

• The pro‐ or anti‐apoptotic function of NF‐κB is determined by the nature of the apoptotic stimulus

  Barbara Kaltschmidt;Christian Kaltschmidt;Thomas G. Hofmann;Steffen P. Hehner

  347
  Citations

• NF‐κB: A Multifaceted Transcription Factor Regulated at Several Levels

  M. Lienhard Schmitz;Ivan Mattioli;Holger Buss;Michael Kracht

  344
  Citations

• Phosphorylation of Serine 468 by GSK-3β Negatively Regulates Basal p65 NF-κB Activity

  Holger Buss;Anneke Dörrie;M. Lienhard Schmitz;Ronald Frank

  333
  Citations

• Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import.

  Ivan Mattioli;Andrea Sebald;Cyril Bucher;Roch-Philippe Charles

  289
  Citations

• Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells.

  M. Lienhard Schmitz;Marcos A. dos Santos Silva;Patrick A. Baeuerle

  238
  Citations

• SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.

  Ya-Chen Liang;Chia-Chin Lee;Ya-Li Yao;Chien-Chen Lai

  213
  Citations

• Mutational Analysis of the SOX9 Gene in Campomelic Dysplasia and Autosomal Sex Reversal: Lack of Genotype/Phenotype Correlations

  Jobst Meyer;Peter Südbeck;Marika Held;Thomas Wagner

  213
  Citations

• Autoregulatory feedback loops terminating the NF-κB response

  Florian Renner;M. Lienhard Schmitz

  211
  Citations

• NF-κB Inhibitors for the Treatment of Inflammatory Diseases and Cancer

  Marco A. Calzado;Susanne Bacher;M. Lienhard Schmitz

  199
  Citations

• HIPK2 Regulates Transforming Growth Factor-β-Induced c-Jun NH2-Terminal Kinase Activation and Apoptosis in Human Hepatoma Cells

  Thomas G. Hofmann;Nicole Stollberg;M. Lienhard Schmitz;Hans Will

  193
  Citations

• PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

  Andreas Möller;Hüseyin Sirma;Thomas G. Hofmann;Sven Rueffer

  181
  Citations