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Karolien De Bosscher

Karolien De Bosscher

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
26121
World Ranking
11097
National Ranking
201

Overview

Karolien De Bosscher is affiliated with Ghent University in Belgium and has a significant body of research work primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research integrates diverse subfields including Molecular Biology, Endocrinology, Diabetes and Metabolism, Genetics, Immunology, and Oncology.

The scientist has contributed extensively to topics such as Estrogen and related hormone effects, Hormonal Regulation and Hypertension, Peroxisome Proliferator-Activated Receptors, Immune Cell Function and Interaction, Multiple Myeloma Research and Treatments, Adrenal Hormones and Disorders, and Peptidase Inhibition and Analysis.

Recent notable publications authored or coauthored by Karolien De Bosscher include:

  • Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation, 2020, Nature Reviews Endocrinology
  • Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis, 2021, Cell Metabolism
  • Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties, 2022, Journal of Chemistry
  • Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies, 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?, 2020, Frontiers in Endocrinology

Collaboration is an important aspect of their scholarly activity. Frequent coauthors include:

  • Dorien Clarisse (22 joint publications)
  • Claude Libert (12 joint publications)
  • Jonathan Thommis (11 joint publications)
  • Steven Timmermans (10 joint publications)
  • Laura Van Moortel (10 joint publications)

The scientist often publishes results in venues such as bioRxiv (Cold Spring Harbor Laboratory), Trends in Biochemical Sciences, Cellular and Molecular Life Sciences, EMBO Molecular Medicine, and EMBO Reports, reflecting a varied presence in both preprint and peer-reviewed journals.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

    Philippe Delerive;Karolien De Bosscher;Sandrine Besnard;Wim Vanden Berghe

  • The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

    Karolien De Bosscher;Wim Vanden Berghe;Guy Haegeman

  • p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

    Wim Vanden Berghe;Stéphane Plaisance;Elke Boone;Karolien De Bosscher

  • Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

    Nadia Bougarne;Basiel Weyers;Sofie J Desmet;Julie Deckers

  • Therapeutic Mechanisms of Glucocorticoids.

    Jolien Vandewalle;Jolien Vandewalle;Astrid Luypaert;Karolien De Bosscher;Claude Libert;Claude Libert

  • How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

    Dariusz Ratman;Wim Vanden Berghe;Lien Dejager;Claude Libert

  • The Nuclear Factor-κB Engages CBP/p300 and Histone Acetyltransferase Activity for Transcriptional Activation of the Interleukin-6 Gene Promoter

    Wim Vanden Berghe;Karolien De Bosscher;Elke Boone;Stéphane Plaisance

  • Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

    Karolien De Bosscher;Wim Vanden Berghe;Linda Vermeulen;Stéphane Plaisance

  • Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.

    Wim Vanden Berghe;Linda Vermeulen;Gert De Wilde;Karolien De Bosscher

  • Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors

    Karolien De Bosscher;Wim Vanden Berghe;Guy Haegeman

  • Minireview: latest perspectives on antiinflammatory actions of glucocorticoids.

    Karolien De Bosscher;Guy Haegeman

  • Crosstalk in inflammation :The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

    Ilse M. E. Beck;Wim Vanden Berghe;Linda Vermeulen;Keith R. Yamamoto

  • Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds

    Marjan Van Cleemput;Ko Cattoor;Karolien De Bosscher;Guy Haegeman

  • A fully dissociated compound of plant origin for inflammatory gene repression

    Karolien De Bosscher;Wim Vanden Berghe;Ilse M. E. Beck;Wim Van Molle

  • A paradigm for gene regulation: inflammation, NF-kappaB and PPAR.

    Wim Vanden Berghe;Linda Vermeulen;Philippe Delerive;Philippe Delerive;Karolien De Bosscher

  • Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds.

    Nora Sundahl;Jolien Bridelance;Claude Libert;Karolien De Bosscher

  • Modulation of Protein–Protein Interactions for the Development of Novel Therapeutics

    Ioanna Petta;Sam Lievens;Claude Libert;Jan Tavernier

  • The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases

    Ioanna Petta;Lien Dejager;Marlies Ballegeer;Sam Lievens

  • The versatile role of MSKs in transcriptional regulation

    Linda Vermeulen;Wim Vanden Berghe;Ilse M.E. Beck;Karolien De Bosscher

Frequent Co-Authors

Guy Haegeman
Guy Haegeman Ghent University
Wim Vanden Berghe
Wim Vanden Berghe University of Antwerp
Claude Libert
Claude Libert Ghent University
Jan Tavernier
Jan Tavernier Ghent University
Bart Staels
Bart Staels University of Lille
Dirk Elewaut
Dirk Elewaut Ghent University
Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Ghislain Opdenakker
Ghislain Opdenakker Rega Institute for Medical Research
Rudi Beyaert
Rudi Beyaert Ghent University
Philippe E. Van den Steen
Philippe E. Van den Steen Rega Institute for Medical Research

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