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Molecular Biology

D-Index
64
Citations
24411
World Ranking
1703
National Ranking
137

Overview

Caroline S. Hill is affiliated with The Francis Crick Institute in the United Kingdom and has a significant body of work primarily in biochemistry, genetics, and molecular biology, with additional contributions to medicine. Their research spans several subfields, including molecular biology, cell biology, oncology, genetics, and pulmonary and respiratory medicine.

Their published work includes recent papers covering various aspects of cell signaling and developmental biology. Notable papers include:

  • Pathogenic ACVR1 R206H activation by Activin A-induced receptor clustering and autophosphorylation, 2021, The EMBO Journal
  • Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways, 2021, Nature Communications
  • Context-dependent TGFβ family signalling in cell fate regulation, 2023, Nature Reviews Molecular Cell Biology
  • Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization, 2021, eLife
  • An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development, 2023, Developmental Cell

Frequent coauthors collaborating with Caroline S. Hill include:

  • Ilaria Gori
  • Luca Guglielmi
  • Merima Mehić
  • Marko Hyvönen
  • Philip East

Their publications are often found in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Developmental Cell
  • Nature Communications
  • Nature Reviews Molecular Cell Biology
  • The EMBO Journal

Caroline S. Hill's primary topics of research include:

  • TGF-β signaling in diseases
  • Developmental Biology and Gene Regulation
  • Pancreatic and Hepatic Oncology Research
  • Zebrafish Biomedical Research Applications
  • Hippo pathway signaling and YAP/TAZ
  • Cancer-related gene regulation
  • Congenital heart defects research

Best Publications

  • The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

    Caroline S. Hill;Judy Wynne;Richard Treisman

  • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

    Gareth J. Inman;Francisco J. Nicolás;James F. Callahan;John D. Harling

  • Transcriptional Regulation by Extracellular Signals: Mechanisms and Specificity

    Caroline S Hill;Richard Treisman

  • New insights into TGF-beta-Smad signalling.

    Peter ten Dijke;Caroline S Hill

  • TGFβ–SMAD signal transduction: molecular specificity and functional flexibility

    Bernhard Schmierer;Caroline S. Hill

  • TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

    Mary Y. Wu;Caroline S. Hill

  • Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.

    Silvia Giampieri;Cerys Manning;Steven Hooper;Louise Jones

  • Alterations in components of the TGF-β superfamily signaling pathways in human cancer

    Laurence Levy;Caroline S. Hill

  • Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity

    Gareth J. Inman;Francisco J. Nicolás;Caroline S. Hill

  • Structure of the HMG box motif in the B-domain of HMG1.

    H.M. Weir;P.J. Kraulis;C.S. Hill;A.R.C. Raine

  • How the Smads regulate transcription

    Sarah Ross;Caroline S. Hill

  • Smad4 Dependency Defines Two Classes of Transforming Growth Factor β (TGF-β) Target Genes and Distinguishes TGF-β-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory Responses

    Laurence Levy;Caroline S. Hill

  • Functional analysis of a growth factor-responsive transcription factor complex

    Caroline S. Hill;Richard Marais;Susan John;Judy Wynne

  • The A‐ and B‐type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

    J. Minshull;R. Golsteyn;C. S. Hill;T. Hunt

  • Beyond TGFβ: roles of other TGFβ superfamily members in cancer

    Lalage M. Wakefield;Caroline S. Hill

  • Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells.

    Kerstin Lehmann;Elzbieta Janda;Christophe E. Pierreux;Marjatta Rytömaa

  • Transcriptional Control by the SMADs

    Caroline S. Hill

  • Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

    Christophe E. Pierreux;Francisco J. Nicolás;Caroline S. Hill

  • Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif.

    Stéphane Germain;Michael Howell;Graeme M. Esslemont;Caroline S. Hill

  • Transforming Growth Factor β-Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

    Amanda C. Daly;Rebecca A. Randall;Caroline S. Hill

Frequent Co-Authors

Michael Howell
Michael Howell The Francis Crick Institute
Richard Treisman
Richard Treisman The Francis Crick Institute
Jean O. Thomas
Jean O. Thomas University of Cambridge
Philip Cohen
Philip Cohen University of Dundee
Erik Sahai
Erik Sahai The Francis Crick Institute
Paul A. Bates
Paul A. Bates The Francis Crick Institute
Laurence Faivre
Laurence Faivre University of Burgundy
Jonathan P. Sleeman
Jonathan P. Sleeman University Medical Centre Mannheim
Ernest D. Laue
Ernest D. Laue University of Cambridge
Karolien De Bosscher
Karolien De Bosscher Ghent University

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