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Xin-Hua Feng

Xin-Hua Feng

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Molecular Biology
China
2025

D-Index & Metrics

Molecular Biology

D-Index
84
Citations
27837
World Ranking
872
National Ranking
12

Research.com Recognitions

  • 2025 - Research.com Molecular Biology in China Leader Award

Overview

Xin-Hua Feng is affiliated with Zhejiang University in China, focusing primarily on the fields of Biochemistry, Genetics and Molecular Biology, with a significant emphasis also in Medicine. Their work spans several subfields including Molecular Biology, Immunology, Oncology, Cell Biology, and Plant Science.

Their research topics cover a wide range of molecular and cellular processes, notably:

  • Interferon and immune responses
  • RNA modifications and cancer
  • Ubiquitin and proteasome pathways
  • Cancer-related gene regulation
  • Hippo pathway signaling and YAP/TAZ
  • TGF-β signaling in diseases
  • RNA and protein synthesis mechanisms

Xin-Hua Feng has contributed to numerous publications, including:

  • "A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis", 2022, Nature Cell Biology
  • "A metabolic labeling method detects m6A transcriptome-wide at single base resolution", 2020, Nature Chemical Biology
  • "Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity", 2021, Molecular Cell
  • "The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability", 2020, Molecular Cell
  • "A subcellular map of the human kinome", 2021, eLife

Frequent publication venues for Xin-Hua Feng include:

  • Molecular Cell (6 publications)
  • Nature Communications (5 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • Nature Cell Biology (4 publications)
  • Science Advances (4 publications)

Collaborations have been an integral part of their work, with frequent co-authors such as:

  • Pinglong Xu
  • Bin Zhao
  • Tingbo Liang
  • Li Shen
  • Xia Lin

Best Publications

  • SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

    Xin-Hua Feng;Rik Derynck

  • Smads: transcriptional activators of TGF-beta responses.

    Rik Derynck;Ying Zhang;Xin-Hua Feng

  • Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

    Xuexian O. Yang;Roza Nurieva;Gustavo J. Martinez;Hong Soon Kang

  • Receptor-associated Mad homologues synergize as effectors of the TGF-β response

    Ying Zhang;Xin-Hua Feng;Rui-Yun Wu;Rik Derynck

  • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

    Ying Zhang;Xin-Hua Feng;Rik Derynck

  • VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.

    Yanan Yue;Jun Liu;Xiaolong Cui;Jie Cao

  • TGF-beta receptor signaling.

    Rik Derynck;Xin-Hua Feng

  • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

    Xin-Hua Feng;Ying Zhang;Rui-Yun Wu;Rik Derynck

  • PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

    Xia Lin;Xueyan Duan;Yao Yun Liang;Ying Su

  • Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

    Xia Lin;Min Liang;Xin-Hua Feng

  • Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β

    Xin‐Hua Feng;Xin‐Hua Feng;Xia Lin;Rik Derynck

  • Phospho-control of TGF-beta superfamily signaling.

    Katharine H Wrighton;Xia Lin;Xin-Hua Feng

  • Microtubule Binding to Smads May Regulate TGFβ Activity

    Chunming Dong;Zhiru Li;Rene Alvarez;Xin Hua Feng

  • Smad7 Antagonizes Transforming Growth Factor β Signaling in the Nucleus by Interfering with Functional Smad-DNA Complex Formation

    Suping Zhang;Teng Fei;Lixia Zhang;Ran Zhang

  • A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

    Masako Miura;Xiao Dong Chen;Matthew R. Allen;Yanming Bi

  • Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15(Ink4B)

    Xin-Hua Feng;Yao-Yun Liang;Min Liang;Weiguo Zhai

  • A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity

    Xin‐Hua Feng;Rik Derynck

  • Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.

    R Y Wu;Y Zhang;X H Feng;R Derynck

  • Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas

    Qi Zhang;Yu Lou;Jiaqi Yang;Junli Wang

  • Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis‐like skin disorder

    Allen G Li;Donna Wang;Xin-Hua Feng;Xiao-Jing Wang

Frequent Co-Authors

Xia Lin
Xia Lin Baylor College of Medicine
Rik Derynck
Rik Derynck University of California, San Francisco
Jun Qin
Jun Qin Baylor College of Medicine
Li Li
Li Li Monash University
Ye-Guang Chen
Ye-Guang Chen Tsinghua University
Chen Dong
Chen Dong Tsinghua University
Jian-Dong Li
Jian-Dong Li Georgia State University
Anming Meng
Anming Meng Tsinghua University
Li Shen
Li Shen Icahn School of Medicine at Mount Sinai
Yi Li
Yi Li University of Michigan–Ann Arbor

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