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Ye-Guang Chen

Ye-Guang Chen

D-Index & Metrics

Molecular Biology

D-Index
75
Citations
51645
World Ranking
1166
National Ranking
20

Overview

Ye-Guang Chen is affiliated with Tsinghua University in China and works primarily in the fields of biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their research spans several key subfields including molecular biology, oncology, genetics, cancer research, and immunology.

Their main areas of focus encompass cancer cells and metastasis, the digestive system and related health, cancer-related gene regulation, TGF-β signaling in diseases, epigenetics and DNA methylation, cancer research and treatments, and Wnt/β-catenin signaling in development and cancer.

Chen has published extensively in several venues, with the highest number of publications appearing in Cell Regeneration, followed by BioEssays, The Journal of Cell Biology, Nature Communications, and Cell Discovery. Frequent collaborators include Yalong Wang, Shicheng Yu, Wanlu Song, Lianzheng Zhao, and Xiaodan Wang.

Recent papers authored or co-authored by Ye-Guang Chen include:

  • A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer, 2020, Cell Discovery
  • BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states, 2022, Cell Reports
  • Phase separation of Axin organizes the β-catenin destruction complex, 2021, The Journal of Cell Biology
  • A gut-derived hormone regulates cholesterol metabolism, 2024, Cell
  • The Interplay Between TGF-β Signaling and Cell Metabolism, 2022, Frontiers in Cell and Developmental Biology

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Controlling TGF-β signaling

    Joan Massagué;Ye-Guang Chen

  • Dishevelled: The hub of Wnt signaling.

    Chan Gao;Ye-Guang Chen

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • TGF-β Signaling from Receptors to Smads.

    Akiko Hata;Ye-Guang Chen

  • PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

    Xia Lin;Xueyan Duan;Yao Yun Liang;Ying Su

  • Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

    Morgan Huse;Ye-Guang Chen;Joan Massagué;John Kuriyan;John Kuriyan

  • The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.

    Morgan Huse;Tom W. Muir;Lan Xu;Ye Guang Chen

  • Regulation of TGF-β signaling by Smad7

    Xiaohua Yan;Ziying Liu;Yeguang Chen

  • Determinants of specificity in TGF-β signal transduction

    Ye-Guang Chen;Akiko Hata;Roger S. Lo;David Wotton

  • Mechanism of TGFbeta receptor inhibition by FKBP12.

    Ye‐Guang Chen;Fang Liu;Joan Massagué

  • Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

    Chan Gao;Weipeng Cao;Lan Bao;Wei Zuo

  • Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

    Geng Wu;Ye-Guang Chen;Barish Ozdamar;Cassie A. Gyuricza

  • Endocytic regulation of TGF-beta signaling.

    Ye-Guang Chen

  • The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptors

    Roger S. Lo;Ye‐Guang Chen;Yigong Shi;Nikola P. Pavletich

  • Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

    Yalong Wang;Wanlu Song;Jilian Wang;Ting Wang

  • Smad7 Antagonizes Transforming Growth Factor β Signaling in the Nucleus by Interfering with Functional Smad-DNA Complex Formation

    Suping Zhang;Teng Fei;Lixia Zhang;Ran Zhang

  • Regulation of cell proliferation, apoptosis, and carcinogenesis by activin.

    Ye-Guang Chen;Hannah M. Lui;Shi-Lung Lin;Jeffery M. Lee

Frequent Co-Authors

Jing-Dong J. Han
Jing-Dong J. Han Peking University
Joan Massagué
Joan Massagué Memorial Sloan Kettering Cancer Center
Anming Meng
Anming Meng Tsinghua University
Xin-Hua Feng
Xin-Hua Feng Zhejiang University
Sergio Lavandero
Sergio Lavandero University of Chile
Evelina Gatti
Evelina Gatti Aix-Marseille University
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Xiao Yang
Xiao Yang Shanghai Jiao Tong University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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