2026 Susan Doris Michaelis: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	60	12036	11087	5160	4626	97	11949

Overview

Susan Doris Michaelis is affiliated with Johns Hopkins University School of Medicine in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Immunology, and Cell Biology as subfields.

The main topics of their work include:

Nuclear Structure and Function
RNA Research and Splicing
Genomics and Chromatin Dynamics
DNA Repair Mechanisms
Interferon and Immune Responses
Cellular Transport and Secretion
Retinoids in Leukemia and Cellular Processes

Their recent papers include the following:

"Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24" (2020), published in Journal of Biological Chemistry
"Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice" (2022), published in Proceedings of the National Academy of Sciences
"The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation" (2022), published in mBio
"Prelamin A and ZMPSTE24 in premature and physiological aging" (2023), published in Nucleus
"A new paradigm for Prelamin A proteolytic processing by ZMPSTE24: the upstream SY^LL cleavage occurs first and there is no CaaX processing by ZMPSTE24" (2020), published in bioRxiv (Cold Spring Harbor Laboratory)

Michaelis frequently collaborates with the following coauthors:

Eric D. Spear
Kamsi O. Odinammadu
Wenxin Xu
Howard J. Worman
Timothy D. Babatz

Their publications often appear in these venues:

bioRxiv (Cold Spring Harbor Laboratory)
Nucleus
Journal of Biological Chemistry
Proceedings of the National Academy of Sciences
mBio

Best Publications

Recombination-mediated PCR-directed plasmid construction in vivo in yeast

Kevin R. Oldenburg;Kham T. Vo;Susan Michaelis;Chris Paddon

661
Citations
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

Martin O. Bergo;Bryant Gavino;Jed Ross;Walter K. Schmidt

516
Citations
Mechanism of incorporation of cell envelope proteins in Escherichia coli.

S Michaelis;J Beckwith

422
Citations
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

Qun Dai;Edwin Choy;Vi Chiu;Julia Romano

419
Citations
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.

C.A. Hrycyna;S.K. Sapperstein;S. Clarke;S. Michaelis

335
Citations
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.

Gregory Huyer;Wachirapon F. Piluek;Zoya Fansler;Stefan G. Kreft

332
Citations
The a-factor pheromone of Saccharomyces cerevisiae is essential for mating.

S Michaelis;I Herskowitz

332
Citations
Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli.

S Michaelis;H Inouye;D Oliver;J Beckwith

326
Citations
Hsp70 Molecular Chaperone Facilitates Endoplasmic Reticulum-associated Protein Degradation of Cystic Fibrosis Transmembrane Conductance Regulator in Yeast

Yimao Zhang;Gaby Nijbroek;Mara L. Sullivan;Ardythe A. McCracken

324
Citations
Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein

Kunio Nakatsukasa;Gregory Huyer;Susan Michaelis;Jeffrey L. Brodsky

315
Citations
Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis

Stephen G. Young;Loren G. Fong;Susan Michaelis

305
Citations
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

Scott Powers;Susan Michaelis;Daniel Broek;Anna A. Sonia Santa

291
Citations
Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

Walter K. Schmidt;Amy Tam;Konomi Fujimura-Kamada;Konomi Fujimura-Kamada;Susan Michaelis

270
Citations
Therapeutic intervention based on protein prenylation and associated modifications

Michael H Gelb;Lucas Brunsveld;Christine A Hrycyna;Susan Michaelis

255
Citations
RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.

Bin He;Peng Chen;Sei-Yu Chen;Kathleen L. Vancura

251
Citations
Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.

C Berkower;S Michaelis

243
Citations
Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

Monica P. Mallampalli;Gregory Huyer;Pravin Bendale;Michael H. Gelb

241
Citations
ABC Transporters in Saccharomyces cerevisiae and Their Interactors: New Technology Advances the Biology of the ABCC (MRP) Subfamily

Christian M. Paumi;Matthew Chuk;Jamie Snider;Igor Stagljar

237
Citations
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

Douglas P. Corrigan;Danuta Kuszczak;Antonio E. Rusinol;Douglas P. Thewke

227
Citations
A Novel Membrane-associated Metalloprotease, Ste24p, Is Required for the First Step of NH2-terminal Processing of the Yeast a-Factor Precursor

Konomi Fujimura-Kamada;Franklin J. Nouvet;Susan Michaelis

218
Citations