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Molecular Biology

D-Index
43
Citations
9977
World Ranking
2958
National Ranking
115

Overview

Damien Arnoult is affiliated with Grenoble Alpes University in France and focuses on research within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields including Molecular Biology, Epidemiology, Cell Biology, Immunology, and Neurology.

Arnoult's primary research topics include:

  • Autophagy in Disease and Therapy
  • Endoplasmic Reticulum Stress and Disease
  • Mitochondrial Function and Pathology
  • Galectins and Cancer Biology
  • RNA regulation and disease
  • Helicobacter pylori-related gastroenterology studies
  • Fungal Plant Pathogen Control

The scientist has contributed to several recent publications, notably:

  • "Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1," 2022, Molecular Cell
  • "The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress," 2020, FEBS Journal
  • "The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates," 2020, Journal of Biological Chemistry
  • "Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics," 2020, EMBO Reports
  • "Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1," 2022, Autophagy

Arnoult frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Molecular Cell
  • FEBS Journal
  • Journal of Biological Chemistry

Collaboration is evident in Arnoult's work, with repeated coauthorship alongside several researchers, including:

  • Dana J. Philpott
  • Stephen E. Girardin
  • Khadija Akarid
  • Samuel A. Killackey
  • Ikram Hammi

Best Publications

  • Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

    Frank Edlich;Soojay Banerjee;Motoshi Suzuki;Megan M. Cleland

  • Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.

    Damien Arnoult;Brigitte Gaume;Mariusz Karbowski;Juanita C. Sharpe

  • Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria

    Bratosin D;Estaquier J;Petit F;Arnoult D

  • Control of mitochondrial permeability by Bcl-2 family members.

    Juanita C. Sharpe;Damien Arnoult;Richard J. Youle

  • Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

    Mariusz Karbowski;Damien Arnoult;Hsiuchen Chen;David C. Chan

  • Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli.

    Damien Arnoult;Philippe Parone;Jean-Claude Martinou;Bruno Antonsson

  • NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

    Ivan Tattoli;Leticia A Carneiro;Muguette Jéhanno;Joao G Magalhaes

  • Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis

    J Estaquier;D Arnoult;D Arnoult

  • Release of OPA1 during Apoptosis Participates in the Rapid and Complete Release of Cytochrome c and Subsequent Mitochondrial Fragmentation

    Damien Arnoult;Damien Arnoult;Alain Grodet;Yang-Ja Lee;Jérôme Estaquier

  • On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization.

    D Arnoult;K Akarid;A Grodet;P X Petit

  • Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria

    Damien Arnoult;Laura M. Bartle;Anna Skaletskaya;Delphine Poncet

  • Mitochondria in innate immunity

    Damien Arnoult;Fraser Soares;Ivan Tattoli;Stephen E Girardin

  • Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death.

    Damien Arnoult;Neggy Rismanchi;Alain Grodet;Roland G. Roberts

  • SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle

    Claudia Figueroa-Romero;Jorge A. Iñiguez-Lluhí;Julia Stadler;Chuang Rung Chang

  • MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

    Céline Castanier;Naima Zemirli;Naima Zemirli;Alain Portier;Alain Portier;Dominique Garcin

  • An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

    Damien Arnoult;Fraser Soares;Ivan Tattoli;Céline Castanier

  • Mitochondrial fragmentation in apoptosis.

    Damien Arnoult

  • On the evolutionary conservation of the cell death pathway: mitochondrial release of an apoptosis-inducing factor during Dictyostelium discoideum cell death.

    Damien Arnoult;Irène Tatischeff;Jérome Estaquier;Mathilde Girard

  • Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential

    Olwenn Guillery;Florence Malka;Florence Malka;Thomas Landes;Emmanuelle Guillou

  • A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division

    Chuang-Rung Chang;Cara Marie Manlandro;Damien Arnoult;Julia Stadler

Frequent Co-Authors

Jérôme Estaquier
Jérôme Estaquier Université Paris Cité
Stephen E. Girardin
Stephen E. Girardin University of Toronto
Dana J. Philpott
Dana J. Philpott University of Toronto
Richard J. Youle
Richard J. Youle National Institutes of Health
Julie Gavard
Julie Gavard University of Nantes
Paul G Ekert
Paul G Ekert University of New South Wales
Jacques Corbeil
Jacques Corbeil Université Laval
Dominique Garcin
Dominique Garcin University of Geneva
Allan J. Hance
Allan J. Hance Université Paris Cité

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