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Molecular Biology

D-Index
125
Citations
104777
World Ranking
221
National Ranking
135

Overview

Richard J. Youle is affiliated with the National Institutes of Health in the United States and has a substantial body of research primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans key subfields such as molecular biology, epidemiology, immunology, cell biology, and neurology, with a focus on diverse topics related to disease mechanisms and cellular processes.

The main research topics covered by Youle include:

  • Autophagy in Disease and Therapy
  • Interferon and Immune Responses
  • Ubiquitin and Proteasome Pathways
  • Mitochondrial Function and Pathology
  • RNA Modifications and Cancer
  • Parkinson's Disease Mechanisms and Treatments
  • Viral Infections and Vectors

Their research contributions have been published in several prominent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Cell Biology
  • Molecular Cell
  • The EMBO Journal
  • Nature Cell Biology

Frequent co-authors collaborating with Youle include Chunxin Wang, François Le Guerroué, Tara D. Fischer, Gil Kanfer, and Eric Bunker, reflecting a consistent collaborative network.

Significant recent publications by Youle include:

  • The mechanisms and roles of selective autophagy in mammals, 2022, Nature Reviews Molecular Cell Biology
  • The role of PINK1-Parkin in mitochondrial quality control, 2024, Nature Cell Biology
  • STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain, 2020, The Journal of Cell Biology
  • Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism, 2020, Brain
  • Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain, 2020, Molecular Cell

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • The BCL-2 protein family: opposing activities that mediate cell death

    Richard J. Youle;Andreas Strasser

  • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

    Derek P. Narendra;Atsushi Tanaka;Der-Fen Suen;Richard J Youle

  • Mitochondrial Fission, Fusion, and Stress

    Richard J. Youle;Alexander M. van der Bliek

  • Mechanisms of mitophagy

    Richard J. Youle;Derek P. Narendra;Derek P. Narendra

  • PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.

    Derek P. Narendra;Seok Min Jin;Atsushi Tanaka;Der Fen Suen

  • The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

    Michael Lazarou;Danielle A. Sliter;Lesley A. Kane;Shireen A. Sarraf

  • Movement of Bax from the Cytosol to Mitochondria during Apoptosis

    Keith G. Wolter;Yi-Te Hsu;Carolyn L. Smith;Amotz Nechushtan

  • The Role of Mitochondria in Apoptosis

    Chunxin Wang;Richard J. Youle

  • The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

    Stephan Frank;Brigitte Gaume;Elke S. Bergmann-Leitner;Wolfgang W. Leitner

  • The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease

    Alicia M. Pickrell;Richard J. Youle

  • Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.

    Sarah Pickles;Pierre Vigié;Richard J. Youle

  • Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

    Jean-Claude Martinou;Richard J. Youle

  • Cytosol-to-membrane redistribution of Bax and Bcl-XL during apoptosis

    Yi Te Hsu;Keith G. Wolter;Richard J. Youle

  • Mitochondrial dynamics and apoptosis

    Der Fen Suen;Kristi L. Norris;Richard J. Youle

  • Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

    Atsushi Tanaka;Megan M. Cleland;Shan-Shan Xu;Derek P. Narendra

  • Structure of Bax: Coregulation of Dimer Formation and Intracellular Localization

    Motoshi Suzuki;Richard J. Youle;Nico Tjandra

  • Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

    Seok Min Jin;Michael Lazarou;Chunxin Wang;Lesley A. Kane

  • Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis

    Yang-ja Lee;Seon-Yong Jeong;Mariusz Karbowski;Carolyn L. Smith

  • PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

    Lesley A. Kane;Michael Lazarou;Adam I. Fogel;Yan Li

Frequent Co-Authors

Mariusz Karbowski
Mariusz Karbowski University of Maryland, Baltimore
David M. Neville
David M. Neville National Institutes of Health
Edward H. Oldfield
Edward H. Oldfield University of Virginia
Nico Tjandra
Nico Tjandra National Institutes of Health
Jean-Claude Martinou
Jean-Claude Martinou University of Geneva
Pascale Cossart
Pascale Cossart Institut Pasteur
Guido Kroemer
Guido Kroemer Université Paris Cité
Alexander M. van der Bliek
Alexander M. van der Bliek University of California, Los Angeles
Mark R. Cookson
Mark R. Cookson National Institutes of Health
Valerio Carelli
Valerio Carelli University of Bologna

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