His primary areas of investigation include Cell biology, Mitochondrion, Apoptosis, mitochondrial fusion and Mitochondrial fission. His Cell biology study combines topics in areas such as Molecular biology, Programmed cell death, Mitophagy and Bcl-2-associated X protein. Richard J. Youle combines subjects such as Parkin and Unfolded protein response with his study of Mitophagy.
In his research, Flip, Cytoplasm and Transport protein is intimately related to Bacterial outer membrane, which falls under the overarching field of Mitochondrion. The mitochondrial fusion study combines topics in areas such as Translocase of the inner membrane and Mitochondrial carrier. His research in Mitochondrial fission focuses on subjects like FIS1, which are connected to MFN1, DNM1L and DNAJA3.
Richard J. Youle focuses on Cell biology, Mitochondrion, Molecular biology, Biochemistry and Apoptosis. His Cell biology research incorporates elements of mitochondrial fusion, Programmed cell death, Mitophagy and Parkin. His research investigates the connection between Mitochondrion and topics such as Bcl-2-associated X protein that intersect with problems in Bcl-2 Homologous Antagonist-Killer Protein.
The study incorporates disciplines such as Transferrin receptor, Immunotoxin, Cytotoxicity and Ricin in addition to Molecular biology. His Immunotoxin study incorporates themes from Pharmacology, Diphtheria toxin and Pathology. In his study, Mitochondrial membrane transport protein is inextricably linked to DNAJA3, which falls within the broad field of Mitochondrial fission.
Cell biology, Mitochondrion, Mitophagy, Parkin and PINK1 are his primary areas of study. His Cell biology study integrates concerns from other disciplines, such as Autophagy, Autophagosome and Biogenesis. His Mitochondrion study combines topics in areas such as Genome, Mitochondrial Degradation, Mitochondrial DNA and Cytosol.
His research in Mitophagy intersects with topics in Mutation, Unfolded protein response, Mitochondrial matrix and Rab. His Parkin research integrates issues from Ubiquitin ligase and White. His studies in PINK1 integrate themes in fields like Endogeny, Chaperone and In vivo.
Richard J. Youle mostly deals with Cell biology, Mitophagy, PINK1, Parkin and Mitochondrion. Richard J. Youle has included themes like Autophagy and FIS1 in his Cell biology study. His Mitophagy study combines topics from a wide range of disciplines, such as Genome and Bioinformatics.
His PINK1 research is multidisciplinary, relying on both Cancer research and Transcription factor, TFEB. His research in Parkin focuses on subjects like Ubiquitin ligase, which are connected to Substantia nigra, Parkinsonism, Microphthalmia-associated transcription factor and ATG5. The concepts of his Mitochondrion study are interwoven with issues in Cell, Mitochondrial Degradation, Cytosol, Unfolded protein response and Programmed cell death.
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Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham.
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle;Andreas Strasser.
Nature Reviews Molecular Cell Biology (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek P. Narendra;Atsushi Tanaka;Der-Fen Suen;Richard J Youle.
Journal of Cell Biology (2008)
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
Keith G. Wolter;Yi-Te Hsu;Carolyn L. Smith;Amotz Nechushtan.
Journal of Cell Biology (1997)
Mitochondrial Fission, Fusion, and Stress
Richard J. Youle;Alexander M. van der Bliek.
Mechanisms of mitophagy
Richard J. Youle;Derek P. Narendra;Derek P. Narendra.
Nature Reviews Molecular Cell Biology (2011)
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Derek P. Narendra;Seok Min Jin;Atsushi Tanaka;Der Fen Suen.
PLOS Biology (2010)
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.
Stephan Frank;Brigitte Gaume;Elke S. Bergmann-Leitner;Wolfgang W. Leitner.
Developmental Cell (2001)
Cytosol-to-membrane redistribution of Bax and Bcl-XL during apoptosis
Yi-Te Hsu;Keith G. Wolter;Richard J. Youle.
Proceedings of the National Academy of Sciences of the United States of America (1997)
The Role of Mitochondria in Apoptosis
Chunxin Wang;Richard J. Youle.
Annual Review of Genetics (2009)
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