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Molecular Biology

D-Index
40
Citations
15126
World Ranking
3067
National Ranking
1451

Overview

Mariusz Karbowski is affiliated with the University of Maryland, Baltimore in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a total of 27 publications. Additionally, their work spans Medicine, contributing to 19 publications.

Their research subfields encompass Molecular Biology, Epidemiology, Physiology, Cardiology and Cardiovascular Medicine, and Oncology. Within these areas, Karbowski has explored a variety of topics including:

  • Mitochondrial Function and Pathology
  • Autophagy in Disease and Therapy
  • Phosphodiesterase Function and Regulation
  • RNA Modifications and Cancer
  • ATP Synthase and ATPases Research
  • Peroxisome Proliferator-Activated Receptors
  • PARP Inhibition in Cancer Therapy

Some of Karbowski's recent publications include:

  • "Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination," 2021, The Journal of Cell Biology
  • "ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import," 2021, Human Molecular Genetics
  • "Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand," 2023, eLife
  • "PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers," 2021, Translational Oncology
  • "Mitochondrial proteotoxicity: implications and ubiquitin-dependent quality control mechanisms," 2022, Cellular and Molecular Life Sciences

The researcher frequently collaborates with colleagues such as Liron Boyman, Nicolas Verhoeven, Maura Greiser, Yumiko Oshima, and W. Jonathan Lederer. These collaborations have resulted in multiple coauthored publications, with the highest number of joint works being with Liron Boyman.

Publication venues where Karbowski's work appears regularly include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Cancer Letters
  • The Journal of Cell Biology
  • Human Molecular Genetics

Best Publications

  • Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

    Atsushi Tanaka;Megan M. Cleland;Shan-Shan Xu;Derek P. Narendra

  • Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis

    Yang-ja Lee;Seon-Yong Jeong;Mariusz Karbowski;Carolyn L. Smith

  • Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

    Mariusz Karbowski;Yang-Ja Lee;Brigitte Gaume;Seon-Yong Jeong

  • Mitochondrial fission in apoptosis.

    Richard J. Youle;Mariusz Karbowski

  • Dynamics of mitochondrial morphology in healthy cells and during apoptosis

    M Karbowski;R J Youle

  • SLP‐2 is required for stress‐induced mitochondrial hyperfusion

    Daniel Tondera;Stéphanie Grandemange;Alexis Jourdain;Mariusz Karbowski

  • Role of Bax and Bak in mitochondrial morphogenesis.

    Mariusz Karbowski;Kristi L. Norris;Megan M. Cleland;Seon-Yong Jeong

  • Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.

    Damien Arnoult;Brigitte Gaume;Mariusz Karbowski;Juanita C. Sharpe

  • The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division

    Mariusz Karbowski;Mariusz Karbowski;Albert Neutzner;Richard J. Youle

  • Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

    Mariusz Karbowski;Damien Arnoult;Hsiuchen Chen;David C. Chan

  • The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species

    Evan A. Bordt;Pascaline Clerc;Brian A. Roelofs;Andrew J. Saladino;Andrew J. Saladino

  • OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.

    Claudia Zanna;Anna Ghelli;Anna Maria Porcelli;Mariusz Karbowski

  • Endophilin B1 is required for the maintenance of mitochondrial morphology

    Mariusz Karbowski;Seon-Yong Jeong;Richard J. Youle

  • The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover.

    Shan Xu;Guihong Peng;Yang Wang;Shengyun Fang

  • Effects of overexpression of Huntingtin proteins on mitochondrial integrity

    Hongmin Wang;Precious J. Lim;Mariusz Karbowski;Mervyn J. Monteiro

  • Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

    Yong-Yea Park;Seungmin Lee;Mariusz Karbowski;Albert Neutzner

  • Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

    Mariusz Karbowski;Richard J Youle

  • Mitochondrial fusion and division: regulation and role in cell viability

    Giovanni Benard;Mariusz Karbowski

  • Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis

    Yoshinori Takahashi;Mariusz Karbowski;Hirohito Yamaguchi;Aslamuzzaman Kazi

  • Neurodegeneration as a consequence of failed mitochondrial maintenance.

    Mariusz Karbowski;Albert Neutzner

Frequent Co-Authors

Richard J. Youle
Richard J. Youle National Institutes of Health
Jiro Usukura
Jiro Usukura Nagoya University
Shengyun Fang
Shengyun Fang University of Maryland, Baltimore
Hiromi Sesaki
Hiromi Sesaki Johns Hopkins University School of Medicine
Valerio Carelli
Valerio Carelli University of Bologna
David C. Chan
David C. Chan California Institute of Technology
Ilia V. Baskakov
Ilia V. Baskakov University of Maryland, Baltimore
Maria R. Baer
Maria R. Baer University of Maryland, Baltimore
Roger A. Nicoll
Roger A. Nicoll University of California, San Francisco
Marcello Pinti
Marcello Pinti University of Modena and Reggio Emilia

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