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Ana J. García-Sáez

Ana J. García-Sáez

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
17047
World Ranking
15928
National Ranking
1120

Overview

Ana J. García-Sáez is affiliated with the University of Cologne in Germany and specializes in biochemistry, genetics, and molecular biology, with a significant research output in molecular biology. Their work spans multiple subfields including immunology, biophysics, pulmonary and respiratory medicine, and cancer research.

The scientist's primary research topics focus on cell death mechanisms and regulation, mitochondrial function and pathology, RNA interference and gene delivery, interferon and immune responses, ATP synthase and ATPases research, ferroptosis and cancer prognosis, and advanced fluorescence microscopy techniques.

Frequent publication venues for their work include FEBS Journal, Cell Death and Differentiation, bioRxiv (Cold Spring Harbor Laboratory), The EMBO Journal, and Molecular Cell.

Recent papers by Ana J. García-Sáez include the following:

  • 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis, 2024, Nature
  • Mechanisms of BCL-2 family proteins in mitochondrial apoptosis, 2023, Nature Reviews Molecular Cell Biology
  • Apoptotic cell death in disease-Current understanding of the NCCD 2023, 2023, Cell Death and Differentiation
  • Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics, 2020, Cell Death and Differentiation
  • The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation, 2022, Molecular Cell

Among frequent co-authors associated with their research are Peter E. Czabotar, Séamus J. Martin, Dublin Chair, Andrey Abramov, and Colin Adrain, each collaborating extensively on various projects.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Bax, Bak and beyond - mitochondrial performance in apoptosis.

    Aida Peña-Blanco;Ana J. García-Sáez;Ana J. García-Sáez

  • Effect of line tension on the lateral organization of lipid membranes

    Ana J. García-Sáez;Salvatore Chiantia;Petra Schwille

  • The secrets of the Bcl-2 family

    A J García-Sáez

  • Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.

    Raquel Salvador‐Gallego;Raquel Salvador‐Gallego;Markus Mund;Katia Cosentino;Katia Cosentino;Jale Schneider

  • Structural Model of Active Bax at the Membrane

    Stephanie Bleicken;Gunnar Jeschke;Carolin Stegmueller;Carolin Stegmueller;Carolin Stegmueller;Raquel Salvador-Gallego;Raquel Salvador-Gallego;Raquel Salvador-Gallego

  • Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics.

    Lohans Pedrera;Rafael A Espiritu;Rafael A Espiritu;Uris Ros;Josephine Weber

  • Mitochondrial alterations in apoptosis.

    Katia Cosentino;Ana Jesus García-Sáez;Ana Jesus García-Sáez;Ana Jesus García-Sáez

  • Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species.

    Yamunadevi Subburaj;Katia Cosentino;Markus Axmann;Esteban Pedrueza-Villalmanzo

  • Bax and Bak Pores: Are We Closing the Circle?

    Katia Cosentino;Ana J. García-Sáez;Ana J. García-Sáez

  • Membrane-insertion fragments of Bcl-xL, Bax, and Bid.

    Ana J. García-Sáez;Ismael Mingarro;Enrique Pérez-Payá;Jesús Salgado

  • Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

    Ana J. García-Sáez;Salvatore Chiantia;Jesús Salgado;Petra Schwille

  • Membrane promotes tBID interaction with BCL XL

    Ana J García-Sáez;Jonas Ries;Mar Orzáez;Enrique Pérez-Payà

  • Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

    Stephanie Bleicken;Stephanie Bleicken;Olatz Landeta;Ane Landajuela;Gorka Basañez

  • Equinatoxin II Permeabilizing Activity Depends on the Presence of Sphingomyelin and Lipid Phase Coexistence

    Peter Schön;Ana J. García-Sáez;Petra Malovrh;Kirsten Bacia

  • Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)-dependent Oligomerization of Fibroblast Growth Factor 2 (FGF2) Triggers the Formation of a Lipidic Membrane Pore Implicated in Unconventional Secretion *

    Julia P. Steringer;Stephanie Bleicken;Stephanie Bleicken;Helena Andreas;Sonja Zacherl

  • Pore formation in regulated cell death.

    Hector Flores-Romero;Uris Ros;Ana J Garcia-Saez

  • Yeast Lipids Can Phase-separate into Micrometer-scale Membrane Domains

    Christian Klose;Christer S. Ejsing;Ana J. García-Sáez;Hermann Josef Kaiser

  • Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores.

    Ana J. García-Sáez;Manuela Coraiola;Mauro Dalla Serra;Ismael Mingarro

  • Fluorescence correlation spectroscopy for the study of membrane dynamics and protein/lipid interactions.

    Ana J. García-Sáez;Petra Schwille

Frequent Co-Authors

Petra Schwille
Petra Schwille Max Planck Society
Andreas Villunger
Andreas Villunger Innsbruck Medical University
Christoph Borner
Christoph Borner University of Freiburg
Leonardo Pardo
Leonardo Pardo Autonomous University of Barcelona
Eyal Gottlieb
Eyal Gottlieb Technion – Israel Institute of Technology
Gyorgy Szabadkai
Gyorgy Szabadkai University College London
Enrique Pérez-Payá
Enrique Pérez-Payá Spanish National Research Council
Walter Nickel
Walter Nickel Heidelberg University
Catherine Brenner
Catherine Brenner Université Paris Cité
Simone Fulda
Simone Fulda Goethe University Frankfurt

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