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Biology and Biochemistry

D-Index
81
Citations
48687
World Ranking
3784
National Ranking
34

Overview

Eyal Gottlieb is affiliated with the Technion - Israel Institute of Technology in Israel. Their research is primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Subfields central to their work include Molecular Biology, Cancer Research, Epidemiology, Physiology, and Genetics.

The scientist has contributed to several research topics, notably:

  • Cancer, Hypoxia, and Metabolism
  • Liver Disease Diagnosis and Treatment
  • Metabolism, Diabetes, and Cancer
  • Epigenetics and DNA Methylation
  • Diet and Metabolism Studies
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism

Some of their recent papers encompass a range of biomedical studies:

  • "The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer," 2021, Nature Genetics
  • "Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome," 2020, Science Translational Medicine
  • "Restoration of energy homeostasis by SIRT6 extends healthy lifespan," 2021, Nature Communications
  • "MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer," 2020, British Journal of Cancer
  • "Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase," 2020, Nature Cancer

The researcher has frequently collaborated with several coauthors throughout their career, including:

  • Ifat Abramovich
  • Bella Agranovich
  • Alia Ghrayeb
  • Inbal Mor
  • Oren Rom

Publication venues commonly featuring their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Journal of Crohn's and Colitis
  • Nature Communications
  • Nature Metabolism

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Succinate is an inflammatory signal that induces IL-1β through HIF-1α

    G. M. Tannahill;A. M. Curtis;J. Adamik;E. M. Palsson-McDermott

  • Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

    Galluzzi L;Vitale I;Vitale I;Vitale I;Abrams Jm;Alnemri Es

  • Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

    Mary A. Selak;Sean M. Armour;Elaine D. MacKenzie;Houda Boulahbel

  • TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

    Karim Bensaad;Atsushi Tsuruta;Mary A. Selak;M. Nieves Calvo Vidal

  • Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

    Evanna L. Mills;Beth Kelly;Angela Logan;Ana S.H. Costa

  • Targeting metabolic transformation for cancer therapy

    Daniel A. Tennant;Raúl V. Durán;Eyal Gottlieb

  • Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

    Oliver D. K. Maddocks;Celia R. Berkers;Susan M. Mason;Liang Zheng

  • Succinate dehydrogenase and fumarate hydratase : linking mitochondrial dysfunction and cancer

    A King;M A Selak;E Gottlieb

  • mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

    Masahiro Morita;Simon Pierre Gravel;Valérie Chénard;Kristina Sikström

  • Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis

    E Gottlieb;S M Armour;M H Harris;C B Thompson

  • Mitochondrial tumour suppressors: A genetic and biochemical update

    Eyal Gottlieb;Ian P. M. Tomlinson

  • Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

    Zachary T. Schug;Barrie Peck;Dylan T. Jones;Qifeng Zhang

  • p53 status determines the role of autophagy in pancreatic tumour development

    Mathias T. Rosenfeldt;Jim O’Prey;Jennifer P. Morton;Colin Nixon

  • Glutaminolysis activates Rag-mTORC1 signaling

    Raúl V. Durán;Wolfgang Oppliger;Aaron M. Robitaille;Lisa Heiserich

  • A roadmap for interpreting 13 C metabolite labeling patterns from cells

    Joerg M. Buescher;Maciek R. Antoniewicz;Laszlo G. Boros;Shawn C Burgess

  • A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

    Joanna Kaplon;Liang Zheng;Katrin Meissl;Barbara Chaneton

  • Serine is a natural ligand and allosteric activator of pyruvate kinase M2

    Barbara Chaneton;Petra Hillmann;Liang Zheng;Agnès C. L. Martin

  • Predicting selective drug targets in cancer through metabolic networks

    Ori Folger;Livnat Jerby;Christian Frezza;Eyal Gottlieb

  • Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

    Christian Frezza;Liang Zheng;Ori Folger;Kartik N. Rajagopalan

Frequent Co-Authors

Christian Frezza
Christian Frezza University of Cambridge
Moshe Oren
Moshe Oren Weizmann Institute of Science
Eytan Ruppin
Eytan Ruppin National Institutes of Health
Karen H. Vousden
Karen H. Vousden The Francis Crick Institute
Karen Blyth
Karen Blyth University of Glasgow
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Frédéric M. Vaz
Frédéric M. Vaz University of Amsterdam
Lorenzo Galluzzi
Lorenzo Galluzzi Cornell University
Sharad Kumar
Sharad Kumar University of Adelaide
Simone Fulda
Simone Fulda Goethe University Frankfurt

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