Receptor, G protein-coupled receptor, Transmembrane domain, Biochemistry and Protein structure are his primary areas of study. In the field of Receptor, his study on Ectodomain overlaps with subjects such as Human chorionic gonadotropin. His G protein-coupled receptor research is multidisciplinary, relying on both Biophysics, Computational biology and Bioinformatics.
In his work, Conformational isomerism, Hydrogen bond and Transmembrane protein is strongly intertwined with Helix, which is a subfield of Transmembrane domain. In his study, which falls under the umbrella issue of Protein structure, Structural motif is strongly linked to Peptide sequence. His Pharmacology research is multidisciplinary, incorporating elements of Opioid receptor, JDTic, Opioid and Serotonin.
His scientific interests lie mostly in G protein-coupled receptor, Receptor, Stereochemistry, Biochemistry and Transmembrane domain. His G protein-coupled receptor research integrates issues from Biophysics, Computational biology, Allosteric regulation and G protein. He combines subjects such as Pharmacology and Cell biology with his study of Receptor.
Leonardo Pardo has included themes like Antagonist and Heteromer in his Pharmacology study. His Stereochemistry study integrates concerns from other disciplines, such as Transmembrane protein, Hydrogen bond, Binding site and Ligand. The various areas that Leonardo Pardo examines in his Transmembrane domain study include Protein structure, Peptide sequence, Helix and Mutant.
His primary scientific interests are in G protein-coupled receptor, Receptor, Cell biology, Allosteric regulation and Adenosine. His G protein-coupled receptor study is concerned with Biochemistry in general. Leonardo Pardo combines topics linked to Amino acid with his work on Receptor.
His work in the fields of Cell biology, such as Signal transduction, G protein and Protein kinase A, overlaps with other areas such as Oncogenic signaling. His Allosteric regulation study deals with Ligand intersecting with Effector and Macromolecular Complexes. In Mutagenesis, Leonardo Pardo works on issues like Alanine, which are connected to Stereochemistry.
Leonardo Pardo mainly investigates Receptor, G protein-coupled receptor, Adenosine A2A receptor, Cell biology and Adenosine. His studies in Receptor integrate themes in fields like Plasma protein binding and Pharmacology. His Plasma protein binding study incorporates themes from Amino acid, Ligand, Bivalent, Transmembrane protein and Stereochemistry.
His G protein-coupled receptor research is included under the broader classification of Biochemistry. His Cell biology research includes themes of Adenosine A1 receptor and Endocannabinoid system. In his study, Heteromer is inextricably linked to Adenosine receptor, which falls within the broad field of Adenosine.
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
Aashish Manglik;Andrew C. Kruse;Tong Sun Kobilka;Foon Sun Thian.
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Michael P. Bokoch;Yaozhong Zou;Søren G F Rasmussen;Corey W. Liu.
A molecular dissection of the glycoprotein hormone receptors.
Gilbert Vassart;Leonardo Pardo;Sabine Costagliola.
Trends in Biochemical Sciences (2004)
Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity
Guillaume Smits;Mercedes Campillo;Cédric Govaerts;Cédric Govaerts;Véronique Janssens.
The EMBO Journal (2003)
Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor Activity
Martine J Smit;Henry F Vischer;Remko A Bakker;Aldo Jongejan.
Annual Review of Pharmacology and Toxicology (2007)
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
Juan José Fung;Xavier Deupi;Leonardo Pardo;Xiao Jie Yao.
The EMBO Journal (2009)
Serine and Threonine Residues Bend α-Helices in the χ1 = g− Conformation
Juan A. Ballesteros;Xavier Deupi;Mireia Olivella;Eric E.J. Haaksma.
Biophysical Journal (2000)
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.
Xavier Viñals;Estefanía Moreno;Laurence Lanfumey;Arnau Cordomí.
PLOS Biology (2015)
The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation.
Cédric Govaerts;Cédric Blanpain;Xavier Deupi;Sébastien Ballet.
Journal of Biological Chemistry (2001)
Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line.
Elisa Pérez-Sacau;Raquel G. Díaz-Peńate;Ana Estévez-Braun;Angel G. Ravelo.
Journal of Medicinal Chemistry (2007)
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