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María L. López-Rodríguez

María L. López-Rodríguez

D-Index & Metrics

Chemistry

D-Index
43
Citations
5406
World Ranking
17355
National Ranking
712

Overview

María L. López-Rodríguez is affiliated with the Complutense University of Madrid in Spain. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, where they have contributed to 26 publications. Within this broad area, their work spans subfields such as Molecular Biology, Cancer Research, Cellular and Molecular Neuroscience, Oncology, and Hematology.

Their research topics include:

  • Peroxisome Proliferator-Activated Receptors
  • Nuclear Structure and Function
  • RNA Research and Splicing
  • Receptor Mechanisms and Signaling
  • Cancer, Lipids, and Metabolism
  • Cancer, Hypoxia, and Metabolism
  • Carbohydrate Chemistry and Synthesis

They have published in a range of venues with particular frequency in:

  • Journal of Medicinal Chemistry
  • Current Medicinal Chemistry
  • Nature
  • ACS Central Science
  • Scientific Reports

Significant recent papers authored or co-authored by María L. López-Rodríguez include:

  • "Glucose metabolism links astroglial mitochondria to cannabinoid effects" (2020, Nature)
  • "Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome" (2021, ACS Central Science)
  • "Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery" (2021, Journal of Medicinal Chemistry)
  • "Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity"" (2022, Journal of Medicinal Chemistry)
  • "Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer-action of FASN-inhibitors: a multi-omics analysis in ovarian cancer" (2020, Scientific Reports)

The scientist frequently collaborates with co-authors including:

  • Henar Vázquez-Villa (6 publications)
  • Mar Martín-Fontecha (4 publications)
  • Silvia Ortega-Gutiérrez (4 publications)
  • Bellinda Benhamú (4 publications)
  • Andrea Escobar-Peña (3 publications)

Best Publications

  • The Antibacterial Cell Division Inhibitor PC190723 Is an FtsZ Polymer-stabilizing Agent That Induces Filament Assembly and Condensation

    José Manuel Andreu;Claudia Schaffner-Barbero;Sonia Huecas;Dulce Alonso

  • Arylpiperazine derivatives acting at 5-HT1A receptors

    M. L. Lopez-Rodriguez;D. Ayala;B. Benhamu;M. J. Morcillo

  • Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

    Bellinda Benhamú;Mar Martín-Fontecha;Henar Vázquez-Villa;Leonardo Pardo

  • Monoacylglycerol lipase (MAGL) as a promising therapeutic target.

    Ana Gil-Ordóñez;Mar Martín-Fontecha;Silvia Ortega-Gutiérrez;María L. López-Rodríguez

  • The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors.

    Leonardo Pardo;Xavier Deupi;Nicole Dölker;María Luz López-Rodríguez

  • Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle.

    Christopher J Fowler;Gunnar Tiger;Alessia Ligresti;Marı́a L López-Rodrı́guez

  • Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

    Teresa Puig;Carlos Turrado;Bellinda Benhamú;Helena Aguilar

  • A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

    Gloria Hernández-Torres;Mariateresa Cipriano;Erika Hedén;Emmelie Björklund

  • A Three-Dimensional Pharmacophore Model for 5-Hydroxytryptamine6 (5-HT6) Receptor Antagonists

    María L López-Rodríguez;Bellinda Benhamú;Tania de la Fuente;Arantxa Sanz

  • Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.

    Maria L. Lopez-Rodriguez;Alma Viso;Silvia Ortega-Gutierrez;Christopher J. Fowler

  • Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake.

    Silvia Ortega-Gutiérrez;E Gregory Hawkins;Alma Viso;María L López-Rodríguez

  • Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.

    María L López-Rodríguez;Esther Porras;M José Morcillo;Bellinda Benhamú

  • Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.

    Maria L. Lopez-Rodriguez;Alma Viso;Silvia Ortega-Gutierrez;Isabel Lastres-Becker

  • Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

    M L López-Rodríguez;M L Rosado;B Benhamú;M J Morcillo

  • Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.

    López-Rodríguez Ml;Rosado Ml;Benhamú B;Morcillo Mj

  • Synthesis and structure-activity relationships of a new model of arylpiperazines. 4. 1-[omega-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene) - 2, 5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2, 5-pyrrolidinediones: study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity.

    M L López-Rodríguez;M J Morcillo;T K Rovat;E Fernández

  • UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide.

    Eva de Lago;Javier Fernández-Ruiz;Silvia Ortega-Gutiérrez;Alma Viso

  • New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity

    Carlos Turrado;Teresa Puig;Javier García-Cárceles;Marta Artola

  • Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT1A/α1-adrenergic receptor affinity : Synthesis of a new derivative with mixed 5-HT1A/D2 antagonist properties

    María L. López-Rodríguez, ,§;M. José Morcillo;Esther Fernández;Esther Porras

  • Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

    Laura B. Ruiz-Avila;Sonia Huecas;Marta Artola;Albert Vergoñós

  • Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 8.1 Computational Simulation of Ligand−Receptor Interaction of 5-HT1AR Agonists with Selectivity over α1-Adrenoceptors

    Maria L. Lopez-Rodriguez;Maria José Morcillo;Esther Fernandez;Bellinda Benhamu

Frequent Co-Authors

Leonardo Pardo
Leonardo Pardo Autonomous University of Barcelona
Jorge Manzanares
Jorge Manzanares Miguel Hernandez University
Alan R. Katritzky
Alan R. Katritzky University of Florida
Javier Fernández-Ruiz
Javier Fernández-Ruiz Complutense University of Madrid
Teresa Puig
Teresa Puig Spanish National Research Council
Oscar Palomares
Oscar Palomares Complutense University of Madrid
José Manuel Andreu
José Manuel Andreu Spanish National Research Council
Joaquín Del Río
Joaquín Del Río University of Navarra
Pedro Grandes
Pedro Grandes University of the Basque Country
Fernando Rodríguez de Fonseca
Fernando Rodríguez de Fonseca Complutense University of Madrid

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