World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
65
Citations
12254
World Ranking
7835
National Ranking
240

Biology and Biochemistry

D-Index
66
Citations
12374
World Ranking
8863
National Ranking
160

Overview

José Manuel Andreu is affiliated with the Spanish National Research Council in Spain and conducts research primarily in the fields of Biochemistry, Genetics, and Molecular Biology as well as Environmental Science. Their work spans several subfields, notably Molecular Biology, Genetics, Ecology, Cell Biology, and Materials Chemistry.

The scientist's research topics include:

  • Bacterial Genetics and Biotechnology
  • Bacteriophages and microbial interactions
  • Enzyme Structure and Function
  • Antibiotic Resistance in Bacteria
  • Microtubule and mitosis dynamics
  • Protist diversity and phylogeny
  • Protein Structure and Dynamics

José Manuel Andreu has published in several scientific journals, with frequent publications in:

  • FEBS Journal
  • PLoS Biology
  • Biomedicines
  • Journal of Medicinal Chemistry
  • Biophysical Journal

Recent papers authored or co-authored by them include:

  • "FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics" (2022), published in PLoS Biology
  • "The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites" (2022), published in Biomedicines
  • "Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery" (2021), published in Journal of Medicinal Chemistry
  • "Nucleotide-induced folding of cell division protein FtsZ from Staphylococcus aureus" (2020), published in FEBS Journal
  • "How Protein Filaments Treadmill" (2020), published in Biophysical Journal

Frequent co-authors include:

  • Federico M. Ruiz
  • Sonia Huecas
  • Carlos Fernández-Tornero
  • Lidia Araújo-Bazán
  • Alicia Santos-Aledo

The scope of José Manuel Andreu's work covers structural and functional studies of bacterial proteins involved in cell division, particularly the FtsZ protein, which is a key component in bacterial cytokinesis. Their research involves biochemical and biophysical approaches to understand protein dynamics and mechanisms of assembly relevant to bacterial growth and division.

This profile reflects the scientist's contributions across various collaborations and their engagement with multiple research topics focused on molecular and cellular microbiology and biochemistry.

Best Publications

  • Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition.

    Jose Fernando Diaz;Jose Manuel Andreu

  • Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action.

    Miguel Abal;José Manuel Andreu;Isabel Barasoain

  • Low-resolution structures of proteins in solution retrieved from X-ray scattering with a genetic algorithm.

    P. Chacón;F. Morán;J.F. Díaz;E. Pantos

  • The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

    Donald E. Pryor;§ Aurora O'Brate;Geoffrey Bilcer;J. Fernando Díaz

  • A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

    Andrea E. Prota;Katja Bargsten;J. Fernando Diaz;May Marsh

  • Peloruside A Does Not Bind to the Taxoid Site on β-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

    Thomas N. Gaitanos;Rubén M. Buey;J. Fernando Díaz;Peter T. Northcote

  • Microtubule Interactions with Chemically Diverse Stabilizing Agents: Thermodynamics of Binding to the Paclitaxel Site Predicts Cytotoxicity

    Rubén M. Buey;Isabel Barasoain;Evelyn Jackson;Arndt Meyer

  • Novel polyphenol oxidase mined from a metagenome expression library of bovine rumen: biochemical properties, structural analysis, and phylogenetic relationships.

    Ana Beloqui;Marcos Pita;Julio Polaina;Arturo Martínez-Arias

  • Magnesium-induced linear self-association of the FtsZ bacterial cell division protein monomer. The primary steps for FtsZ assembly.

    Germán Rivas;Asunción López;Jesús Mingorance;Marı́a José Ferrándiz

  • Essential cell division protein FtsZ assembles into one monomer-thick ribbons under conditions resembling the crowded intracellular environment.

    José Manuel González;Mercedes Jiménez;Marisela Vélez;Jesús Mingorance

  • The Antibacterial Cell Division Inhibitor PC190723 Is an FtsZ Polymer-stabilizing Agent That Induces Filament Assembly and Condensation

    José Manuel Andreu;Claudia Schaffner-Barbero;Sonia Huecas;Dulce Alonso

  • Conformational states of tubulin liganded to colchicine, tropolone methyl ether, and podophyllotoxin.

    Jose Manuel Andreu;Serge N. Timasheff

  • Low resolution structure of microtubules in solution: Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in comparison with glycerol and MAP-induced microtubules

    J.M. Andreu;J. Bordas;J.F. Diaz;J.García de Ancos

  • Interaction of tubulin with single ring analogues of colchicine.

    Jose Manuel Andreu;Serge N. Timasheff

  • Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites

    Rubén M Buey;Enrique Calvo;Isabel Barasoain;Oriol Pineda

  • Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site

    José Fernando Díaz;Rik Strobe;Yves Engelborghs;André A. Souto

  • Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamics.

    J. Fernando Dı́az;J. Fernando Dı́az;José M. Valpuesta;Pablo Chacón;Greg Diakun

  • Structure of bacterial tubulin BtubA/B: Evidence for horizontal gene transfer

    Daniel Schlieper;María A. Oliva;José Manuel Andreu;Jan Löwe

  • Reconstruction of protein form with X-ray solution scattering and a genetic algorithm.

    Pablo Chacón;J.Fernando Dı́az;Federico Morán;José M. Andreu

  • Energetics and Geometry of FtsZ Polymers : Nucleated Self-Assembly of Single Protofilaments

    Sonia Huecas;Oscar Llorca;Jasminka Boskovic;Jaime Martín-Benito

  • Novel Polyphenol Oxidase Mined from a Metagenome Expression Library of Bovine Rumen

    Ana Beloqui;Marcos Pita;Julio Polaina;Arturo Martínez-Arias

Frequent Co-Authors

Serge N. Timasheff
Serge N. Timasheff Brandeis University
David Andreu
David Andreu Pompeu Fabra University
Francisco Amat-Guerri
Francisco Amat-Guerri Spanish National Research Council
Germán Rivas
Germán Rivas Spanish National Research Council
María L. López-Rodríguez
María L. López-Rodríguez Complutense University of Madrid
Jan Löwe
Jan Löwe MRC Laboratory of Molecular Biology
Peter N. Golyshin
Peter N. Golyshin Bangor University
José M. Valpuesta
José M. Valpuesta Spanish National Research Council

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