Karl-Heinz Altmann

Overview

Best Publications

• The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically-modified DNA:RNA duplexes

  Susan M. Freier;Karl-Heinz Altmann

  1361
  Citations

• Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.

  Andrea E. Prota;Katja Bargsten;Didier Zurwerra;Jessica J. Field

  545
  Citations

• Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

  Annemarie Ziegler;Gerd H. Luedke;Doriano Fabbro;Karl Heinz Altmann

  342
  Citations

• Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.

  Scott M. Jackson;Ioannis Manolaridis;Julia Kowal;Melanie Zechner

  335
  Citations

• Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals.

  K.-H. Altmann;N. M. Dean;D. Fabbro;S. M. Freier

  332
  Citations

• Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects.

  Stefan Raduner;Adriana Majewska;Jian-Zhong Chen;Xiang-Qun Xie

  329
  Citations

• A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

  Andrea E. Prota;Katja Bargsten;J. Fernando Diaz;May Marsh

  297
  Citations

• Puromycin-sensitive aminopeptidases

  Adriano Fontana;Daniel Beat Constam;Andreas Rudolf Tobler;Karl-Heinz Altmann

  291
  Citations

• Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.

  Karl-Heinz Altmann;Markus Wartmann;Terence O’Reilly

  289
  Citations

• GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts.

  Dietmar Benke;Andrea Barberis;Sascha Kopp;Karl Heinz Altmann

  265
  Citations

• Template-Assembled Synthetic Proteins with 4-Helix-Bundle Topology - Total Chemical Synthesis and Conformational Studies

  Manfred Mutter;Gabriele G. Tuchscherer;Charleen Miller;Karl Heinz Altmann

  260
  Citations

• SECOND-GENERATION ANTISENSE OLIGONUCLEOTIDES : STRUCTURE-ACTIVITY RELATIONSHIPS AND THE DESIGN OF IMPROVED SIGNAL-TRANSDUCTION INHIBITORS

  K H Altmann;D Fabbro;N M Dean;T Geiger

  247
  Citations

• Backbone modifications in oligonucleotides and peptide nucleic acid systems

  Alain De Mesmaeker;Karl-Heinz Altmann;Adrian Waldner;Sebastian Wendeborn

  223
  Citations

• Structural basis of microtubule stabilization by laulimalide and peloruside a.

  Andrea E. Prota;Katja Bargsten;Peter T. Northcote;May Marsh

  218
  Citations

• Helix‐coil stability constants for the naturally occurring amino acids in water. XXIV. Half‐cystine parameters from random poly(hydroxybutylglutamine‐CO‐S‐methylthio‐L‐cysteine)

  J. Wójcik;K.-H. Altmann;H. A. Scheraga

  211
  Citations

• 4′,6′-Methano carbocyclic thymidine: A conformationally constrained building block for oligonucleotides

  Karl-Heinz Altmann;Rudolf Kesselring;Eric Francotte;Grety Rihs

  193
  Citations

• Chemical synthesis and biological properties of pyridine epothilones

  K C Nicolaou;R Scarpelli;B Bollbuck;B Werschkun

  188
  Citations

• Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

  K. C. Nicolaou;K. C. Nicolaou;Kenji Namoto;Kenji Namoto;Andreas Ritzén;Andreas Ritzén;Trond Ulven;Trond Ulven

  177
  Citations

• The chemistry and biology of epothilones--the wheel keeps turning.

  Karl-Heinz Altmann;Bernhard Pfeiffer;Stellios Arseniyadis;Benjamin A. Pratt

  155
  Citations

• Microtubule-stabilizing agents: a growing class of important anticancer drugs.

  Unknown

  145
  Citations

• Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts.

  Andrea Chicca;Stefan Raduner;Federica Pellati;Thomas Strompen

  142
  Citations

• A collection of robust organic synthesis reactions for in silico molecule design.

  Markus Hartenfeller;Martin Eberle;Peter Meier;Cristina Nieto-Oberhuber

  141
  Citations

• Second Generation Antisense Oligonucleotides—Inhibition of PKC-α and c-raf Kinase Expression by Chimeric Oligonucleotides Incorporating 6″-Substituted Carbocyclic Nucleosides and 2″-O-Ethylene Glycol Substituted Ribonucleosides

  Karl-Heinz Altmann;Pierre Martin;Nicholas M. Dean;Brett P. Mania

  133
  Citations

• The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.

  Teresa Carlomagno;Marcel J. J. Blommers;Jens Meiler;Jens Meiler;Wolfgang Jahnke

  130
  Citations

• 1′,6′-methano carbocyclic thymidine: Synthesis, x-ray crystal structure, and effect on nucleic acid duplex stability

  Karl-Heinz Altmann;René Imwinkelried;Rudolf Kesselring;Grety Rihs

  130
  Citations

• Switch Peptides: pH‐Induced α‐Helix to β‐Sheet Transitions of Bis‐amphiphilic Oligopeptides

  Manfred Mutter;R. Gassmann;U. Buttkus;K.-H. Altmann

  126
  Citations

• Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin

  Marco Leonti;Laura Casu;Stefan Raduner;Filippo Cottiglia

  123
  Citations

• Epothilone B and its analogs - a new family of anticancer agents.

  Unknown

  122
  Citations

• Dual Recognition of Double-Stranded DNA by 2'-Aminoethoxy-Modified Oligonucleotides.

  Unknown

  114
  Citations