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Biology and Biochemistry

D-Index
101
Citations
40437
World Ranking
1431
National Ranking
817

Overview

Brett P. Monia is affiliated with Ionis Pharmaceuticals in the United States. Their body of research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with extensive work in molecular biology, hematology, genetics, immunology, and cell biology.

The scientific contributions of Monia encompass various topics, including:

  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Blood Coagulation and Thrombosis Mechanisms
  • Cellular transport and secretion
  • Lipoproteins and Cardiovascular Health
  • Protein Kinase Regulation and GTPase Signaling
  • Systemic Lupus Erythematosus Research

Monia has published multiple peer-reviewed papers, some of the recent works include:

  • An oral antisense oligonucleotide for PCSK9 inhibition, 2021, Science Translational Medicine
  • Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data, 2020, ESC Heart Failure
  • Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice, 2021, Journal of Thrombosis and Haemostasis
  • Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy, 2021, Neurology and Therapy
  • Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-induced Goblet Cell Metaplasia in the Adult Murine Lung, 2020, American Journal of Respiratory Cell and Molecular Biology

Frequent collaborators in Monia's research include:

  • Richard S. Geary
  • Eugene Schneider
  • Alexey S. Revenko
  • Rosie Z. Yu
  • Scott P. Henry

Their work has been published regularly in several notable scientific journals such as Nucleic Acid Therapeutics, Circulation, Research and Practice in Thrombosis and Haemostasis, Science Translational Medicine, and ESC Heart Failure.

Best Publications

  • miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

    Christine Esau;Scott Davis;Susan F. Murray;Xing Xian Yu

  • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

    Yoichi Nagata;Keng Hsueh Lan;Xiaoyan Zhou;Ming Tan

  • Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression

    B P Monia;E A Lesnik;C Gonzalez;W F Lima

  • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.

    Kanji Yamaguchi;Liu Yang;Shannon McCall;Jiawen Huang

  • Gapped 2' modified oligonucleotides

    Phillip Dan Cook;Brett P. Monia

  • Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C- raf kinase

    Brett P. Monia;Joseph F. Johnston;Thomas Geiger;Marcel Muller

  • Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

    Thazha P. Prakash;Mark J. Graham;Jinghua Yu;Rick Carty

  • Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

    Eric E. Swayze;Andrew M. Siwkowski;Edward V. Wancewicz;Michael T. Migawa

  • Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

    Sophie Derenne;Brett Monia;Nicholas M. Dean;Jennifer K. Taylor

  • Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

    Harry Roger Buller;Claudette Bethune;Sanjay Bhanot;David Gailani

  • Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

    Varman T. Samuel;Zhen-Xiang Liu;Amy Wang;Sara A. Beddow

  • Antisense oligonucleotide therapy for neurodegenerative disease

    Richard A. Smith;Timothy M. Miller;Koji Yamanaka;Brett P. Monia

  • Role of resistin in diet-induced hepatic insulin resistance

    Evan D. Muse;Silvana Obici;Sanjay Bhanot;Brett P. Monia

  • Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

    David B. Savage;Cheol Soo Choi;Varman T. Samuel;Zhen-Xiang Liu

  • Nicotinamide N -methyltransferase knockdown protects against diet-induced obesity

    Daniel Kraus;Qin Yang;Dong Kong;Alexander S. Banks

  • Antisense therapy for cancer.

    Martin E. Gleave;Brett P. Monia

  • Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

    Cheol Soo Choi;David B. Savage;Ameya Kulkarni;Xing Xian Yu

  • AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

    David Sanghyun Hong;Razelle Kurzrock;Youngsoo Kim;Richard Woessner

  • Critical Role of stearoyl-CoA desaturase-1 (SCD1) in the Onset of Diet-Induced Hepatic Insulin Resistance

    Roger Gutiérrez-Juárez;Alessandro Pocai;Claudia Mulas;Hiraku Ono

  • PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients.

    Keng-Hsueh Lan;Yoichi Nagata;Xiaoyan Zhou;Francisco J. Esteva

Frequent Co-Authors

Richard S. Geary
Richard S. Geary Ionis Pharmaceuticals (United States)
Nicholas M. Dean
Nicholas M. Dean Ionis Pharmaceuticals (United States)
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)
David J. Ecker
David J. Ecker Ionis Pharmaceuticals (United States)
Merrill D. Benson
Merrill D. Benson Indiana University
Martin E. Gleave
Martin E. Gleave University of British Columbia
Eric E. Swayze
Eric E. Swayze Ionis Pharmaceuticals (United States)
Burkhard Jansen
Burkhard Jansen University of British Columbia
Punit P. Seth
Punit P. Seth Ionis Pharmaceuticals (United States)
Sotirios Tsimikas
Sotirios Tsimikas University of California, San Diego

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